scholarly journals PROTOPLASMIC INCOMPATIBILITY AND CELL LYSIS IN PODOSPORA ANSERINA. I. GENETIC INVESTIGATIONS ON MUTATIONS OF A NOVEL MODIFIER GENE THAT SUPPRESSES CELL DESTRUCTION

Genetics ◽  
1977 ◽  
Vol 87 (2) ◽  
pp. 249-257
Author(s):  
Jacques Labarere ◽  
Jean Bernet
Keyword(s):  
Cell Lysis ◽  
Podospora Anserina ◽  
Modifier Gene ◽  
The Self ◽  
Obvious Effect ◽  
Type Locus ◽  
Modifier Locus ◽  
The Third ◽  
Cell Destruction ◽  
Mutant Strains

ABSTRACT In Podospora anserina, protoplasmic incompatibility (a phenomenon that prevents heterokaryon formation because of the destruction of the fused cells) can be studied in homokaryotic strains that combine nonallelic incompatibility genes or carry mutations at the lys loci. In these strains cell destruction occurs early in development and is associated with an arrest of growth.—From the self-lysing strains lysA(1) and RV (R and V are nonallelic incompatibility genes) mutations have been selected that suppress the self-lysing trait, i.e., that prevent cell destruction and remove growth inhibition. Some of them were derived from a novel modifier locus, modC, located near the mating-type locus.—In C/D and C/E incompatibility systems, modC mutations, which per se have no obvious effect, were considered in addition to mutations in the previously identified modifier loci, modA and modB. The demonstration of a functional interdependence among the three mod genes suggested that modC is not the structural gene for the protease associated with cell lysis, but is involved, like modA and modB, in its control.—All three modC mutant strains investigated exhibit defects in the formation of protoperithecia, suggesting that the modC gene function is essential to the occurrence or development of the female organs. This is the third argument that supports the hypothesis (Boucherie, Bégueret and Bernet 1976) that protoplasmic incompatibility and female organ formation might be related phenomena.

Pèlerinages barrésiens

2013 ◽  
pp. 116-123
Author(s):  
Claire Bompaire-Evesque
Keyword(s):  
Large Scale ◽  
The Self ◽  
Joan Of Arc ◽  
The Third ◽  
National Importance ◽  
The Earth ◽  
Third Stage ◽  
The Dead

This article is a inquiry about how Barrès (1862-1923) handles the religious rite of pilgrimage. Barrès stages in his writings three successive forms of pilgrimage, revealing what is sacred to him at different times. The pilgrimage to a museum or to the birthplace of an artist is typical for the egotism and the humanism of the young Barrès, expressed in the Cult of the Self (1888-1891). After his conversion to nationalism, Barrès tries to unite the sons of France and to instill in them a solemn reverence for “the earth and the dead” ; for that purpose he encourages in French Amities (1903) pilgrimages to historical places of national importance (battlefields; birthplace of Joan of Arc), building what Nora later called the Realms of Memory. The third stage of Barrès’ intellectual evolution is exemplified by The Sacred Hill (1913). In this book the writer celebrates the places where “the Spirit blows”, and proves open to a large scale of spiritual forces, reaching back to paganism and forward to integrative syncretism, which aims at unifying “the entire realm of the sacred”.

Delving into Horror

2019 ◽  
Vol 29 (5) ◽  
pp. 135-150
Keyword(s):  
The Self ◽  
Time And Space ◽  
The Third ◽  
The World ◽  
The Subject ◽  
Perception Of Time ◽  
Definition Of

The springboard for this essay is the author’s encounter with the feeling of horror and her attempts to understand what place horror has in philosophy. The inquiry relies upon Leonid Lipavsky’s “Investigation of Horror” and on various textual plunges into the fanged and clawed (and possibly noumenal) abyss of Nick Land’s work. Various experiences of horror are examined in order to build something of a typology, while also distilling the elements characteristic of the experience of horror in general. The essay’s overall hypothesis is that horror arises from a disruption of the usual ways of determining the boundaries between external things and the self, and this leads to a distinction between three subtypes of horror. In the first subtype, horror begins with the indeterminacy at the boundaries of things, a confrontation with something that defeats attempts to define it and thereby calls into question the definition of the self. In the second subtype, horror springs from the inability to determine one’s own boundaries, a process opposed by the crushing determinacy of the world. In the third subtype, horror unfolds by means of a substitution of one determinacy by another which is unexpected and ungrounded. In all three subtypes of horror, the disturbance of determinacy deprives the subject, the thinking entity, of its customary foundation for thought, and even of an explanation of how that foundation was lost; at times this can lead to impairment of the perception of time and space. Understood this way, horror comes within a hair’s breadth of madness - and may well cross over into it.

scholarly journals Identification of Six Loci in Which Mutations Partially Restore Peroxisome Biogenesis and/or Alleviate the Metabolic Defect of pex2 Mutants in Podospora

Genetics ◽  
2002 ◽  
Vol 161 (3) ◽  
pp. 1089-1099
Author(s):  
Gwenaël Ruprich-Robert ◽  
Véronique Berteaux-Lecellier ◽  
Denise Zickler ◽  
Arlette Panvier-Adoutte ◽  
Marguerite Picard
Keyword(s):  
Sole Carbon Source ◽  
Large Scale ◽  
Podospora Anserina ◽  
Developmental Defect ◽  
Dominant Allele ◽  
Peroxisome Biogenesis ◽  
Metabolic Defects ◽  
Metabolic Defect ◽  
Mutant Strains ◽  
Large Scale Screening

Abstract Peroxins (PEX) are proteins required for peroxisome biogenesis. Mutations in PEX genes cause lethal diseases in humans, metabolic defects in yeasts, and developmental disfunctions in plants and filamentous fungi. Here we describe the first large-scale screening for suppressors of a pex mutation. In Podospora anserina, pex2 mutants exhibit a metabolic defect [inability to grow on medium containing oleic acid (OA medium) as sole carbon source] and a developmental defect (inability to differentiate asci in homozygous crosses). Sixty-three mutations able to restore growth of pex2 mutants on OA medium have been analyzed. They fall in six loci (suo1 to suo6) and act as dominant, allele-nonspecific suppressors. Most suo mutations have pleiotropic effects in a pex2+ background: formation of unripe ascospores (all loci except suo5 and suo6), impaired growth on OA medium (all loci except suo4 and suo6), or sexual defects (suo4). Using immunofluorescence and GFP staining, we show that peroxisome biogenesis is partially restored along with a low level of ascus differentiation in pex2 mutant strains carrying either the suo5 or the suo6 mutations. The data are discussed with respect to β-oxidation of fatty acids, peroxisome biogenesis, and cell differentiation.

scholarly journals Latent Profiles of Burnout, Self-Esteem and Depressive Symptomatology among Teachers

2020 ◽  
Vol 17 (18) ◽  
pp. 6760
Author(s):  
Inmaculada Méndez ◽  
Juan Pedro Martínez-Ramón ◽  
Cecilia Ruiz-Esteban ◽  
José Manuel García-Fernández
Keyword(s):  
Emotional Exhaustion ◽  
Depressive Symptomatology ◽  
Maslach Burnout Inventory ◽  
Self Esteem ◽  
Personal Accomplishment ◽  
The Self ◽  
Teaching Staff ◽  
The Third ◽  
Group 2 ◽  
Group 1

Burnout is a reality in the teaching profession. Specifically, teaching staff usually have higher burnout rates. The present study aims to analyze the different burnout profiles and to verify if there were differences between burnout profiles in depressive symptomatology and in the self-esteem of the teachers at school. The total number of participants was 210 teachers from 30 to 65 years. The first scale was the Maslach burnout inventory, the second scale was the Self-Rating depression scale and the third scale was the Rosenberg Self-Esteem Scale. The latent class analysis identified three burnout profiles: the first group with a high level of emotional exhaustion, low personal accomplishment and depersonalization (high burnout); the second group with low emotional exhaustion, low depersonalization and high personal accomplishment (low burnout) and the third group with low depersonalization, low emotional exhaustion and low personal accomplishment (moderate burnout). The results revealed that there were differences in depressive symptomatology (group 1 obtained higher scores than group 2 and group 3) and self-esteem (group 2 obtained higher scores than group 1). The psychological balance and health of teachers depend on preventing the factors that have been associated with this syndrome.

scholarly journals Sexuality in Neurospora crassa I. Mutations to male sterility

1972 ◽  
Vol 19 (3) ◽  
pp. 191-204 ◽  
Author(s):  
J. Weijer ◽  
N. V. Vigfusson
Keyword(s):  
Neurospora Crassa ◽  
Male Sterility ◽  
Wide Spectrum ◽  
Female Parent ◽  
Behaviour Pattern ◽  
Type Locus ◽  
Development Cycle ◽  
Ultraviolet Light Irradiation ◽  
Mutant Strains ◽  
Aberrant Segregation

SUMMARYMutations giving rise to sexual sterility were induced in Neurospora crassa macroconidia by ultraviolet-light irradiation. Thirty mutants were isolated on the basis of their male sterility in crosses with a wild-type strain. When used as the male parent these mutants exhibited a wide spectrum of sexual behaviour patterns ranging from the production of only small brown protoperithecia (complete male sterility) to the production of large and normally pigmented perithecia but with an undeveloped ostiole and very few if any spores. For many of the mutants the behaviour pattern is different when the strain is used as the female parent. Segregation data reveal that none of these mutants represent mutations of the mating-type locus. These findings suggest that the sexual development cycle is blocked at various stages in the different mutant strains. All attempts to restore fertility by supplying various additives to the medium or by varying the incubation time and temperature were unsuccessful. Conidial viability tests carried out on many of the strains revealed no abnormality in this respect. The aberrant segregation patterns exhibited by many of the mutants are discussed.

Natur als Metapher

1997 ◽  
Vol 2 ◽  
pp. 47-67
Author(s):  
Johann Kreuzer
Keyword(s):  
The Self ◽  
The Third ◽  
Fourth Part

Abstract The first part of this essay treats Eriugena's concept of theophany. Because nature is to be understood as theophany, every visible and invisible creature is a divina apparitio. The second part explains that appearing nature is the metaphor of a creative principle. Metaphor is the inner structure of nature as a process of appearance and the inner structure of our speaking about nature as metaphor. The third part infers that the recognition of nature as metaphor is based upon the thinking of appearance. To understand the cause through which every phenomenon of nature becomes a metaphor means to understand the dialectic of appearing nature: it means to understand nature as apparitio non apparentis. The fourth part concludes that in moments of beauty we recognize the nature of metaphor and nature as metaphor. Beauty is the givenness of what we think as the vivid cause of appearing nature. Its cause - and beauty fundamentally - is the self-consciousness of nature as appearance. Both nature as well as beauty are nonmetaphorical metaphors of themselves.

scholarly journals ‘THE RULE OF THREE’ IN THE GROWTH STORIES – GANGBAIK LEE’S DRAMA “LIKE LOOKING AT THE FLOWER IN THE MIDWINTER”

2016 ◽  
Vol 1 ◽  
pp. 11-22
Author(s):  
Mansu KIM
Keyword(s):  
Fairy Tale ◽  
The Self ◽  
The Real ◽  
Final Destination ◽  
The Third ◽  
The Core ◽  
Rule Of Three ◽  
The Poor ◽  
The World

This paper focused on the structure of the growth stories, especially in surveying Gangbaek Lee’s (이강백) drama “Like Looking at the Flower in the Mid-winter (동지섣달 꽃 본 듯이)”. It is structured by ‘rule of the three’. In this text, three sons go to seek their mother, they experience the tests three times. Third son wins the game because he succeeds to find his true and alternative mother. It is similar to the story of English fairy tale “Three Little Pigs”.  In Freudian terms, the characters of the both texts are superego, ego and id. The core of the growth story is that third son (id) wins the first son (superego) and the second son (ego) by using his own energy (meaningful labor). In Levi Strauss’ terms, the contrast between the third and the others can be schemed the contrast between culture and nature. Lee’s drama presents the third son as the real hero who overcomes two elder brothers. The first is so conservative (oversleep), the second is so selfish (overeat). Two brothers were too political or too ideal to become a true, humanistic and warm-minded adult. In his view, ‘drama’ related to the third son is the most humanistic and warm-minded action in the world. These both stories are based on the plot ‘rags to riches’ which contains the success of the poor and powerless. In other words, the poor and weak child can grow to the true hero, and reach the final destination, according to the Gustav Jung’s expression, ‘the Self as a Whole’.

scholarly journals Wybrane płaszczyzny sporu o samorząd terytorialny w początkach III Rzeczpospolitej

2020 ◽  
pp. 86-103
Author(s):  
Paweł Gofron
Keyword(s):  
Third Republic ◽  
Round Table ◽  
The Self ◽  
The Political ◽  
Political Transformation ◽  
The Third ◽  
Implementation Scheme

Selected grounds of strife over the self ‑government at the beginning of the Third Polish RepublicThis article presents the selected grounds of strife over the self-govern-ment in Poland during the political transformation – from the end of the Polish People’s Republic to the beginning of the Third Republic of Poland. In the introduction the importance of the self -government re-form was emphasized. In the main content the discourse over the self--government during the Round Table Talks was reconstructed in outli-ne. Moreover, the projects of the implementation scheme of the reform were discussed. The last part of the text concerns the dispute over the introduction of poviats as the second level of self -government.

scholarly journals The Foucault Effect in Organization Studies

2017 ◽  
Vol 40 (2) ◽  
pp. 155-182 ◽  
Author(s):  
Sverre Raffnsøe ◽  
Andrea Mennicken ◽  
Peter Miller
Keyword(s):  
Twentieth Century ◽  
The Self ◽  
Third Wave ◽  
Organization Studies ◽  
Linguistic Turn ◽  
The Third ◽  
The Past ◽  
Organizational Scholarship ◽  
The Impact ◽  
Second Wave

Since the establishment of Organization Studies in 1980, Michel Foucault’s oeuvre has had a remarkable and continuing influence on its field. This article traces the different ways in which organizational scholars have engaged with Foucault’s writings over the past thirty years or so. We identify four overlapping waves of influence. Drawing on Foucault’s Discipline and Punish, the first wave focused on the impact of discipline, and techniques of surveillance and subjugation, on organizational practices and power relations. Part of a much wider ‘linguistic’ turn in the second half of the twentieth century, the second wave led to a focus on discourses as intermediaries that condition ways of viewing and acting. This wave drew mainly on Foucault’s early writings on language and discourse. The third wave was inspired by Foucault’s seminal lectures on governmentality towards the end of the 1970s. Here, an important body of international research investigating governmental technologies operating on subjects as free persons in sites such as education, accounting, medicine and psychiatry emerged. The fourth and last wave arose out of a critical engagement with earlier Foucauldian organizational scholarship and sought to develop a more positive conception of subjectivity. This wave draws in particular on Foucault’s work on asceticism and techniques of the self towards the end of his life. Drawing on Deleuze and Butler, the article conceives the Foucault effect in organization studies as an immanent cause and a performative effect. We argue for the need to move beyond the tired dichotomies between discipline and autonomy, compliance and resistance, power and freedom that, at least to some extent, still hamper organization studies. We seek to overcome such dichotomies by further pursuing newly emerging lines of Foucauldian research that investigate processes of organizing, calculating and economizing characterized by a differential structuring of freedom, performative and indirect agency.

The Study of Online Recharging for Campus Cards Based on the Third-Party Payment Platform

2014 ◽  
Vol 926-930 ◽  
pp. 2253-2258
Author(s):  
Hui Lin Zhang ◽  
Yu Zhang ◽  
Wen Feng Zhong ◽  
Ming Yuan Li
Keyword(s):  
Business Processes ◽  
The Self ◽  
Third Party ◽  
Fund Flows ◽  
The Third ◽  
Self Help ◽  
The Third Party

In order to enrich campus card recharging methods and improve the cardholders experience, this paper first briefly introduces the campus card online recharging modes based on the third-party payment platform, then analyzes the business processes of the self-help recharging mode and the automatic recharging mode, introduces the validation processes of the transactions, and expounds the fund flows and the double reconciliation mechanism at last.

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