scholarly journals ENZYME POLYMORPHISMS: GENE FREQUENCY DISTRIBUTIONS WITH MUTATION AND SELECTION FOR OPTIMAL ACTIVITY

Genetics ◽  
1975 ◽  
Vol 79 (2) ◽  
pp. 325-331
Author(s):  
B D H Latter
Keyword(s):  
Alternative Model ◽  
Gene Frequency ◽  
Large Scale ◽  
Genetic Model ◽  
Optimal Level ◽  
Frequency Distributions ◽  
Optimal Activity ◽  
The Mean ◽  
Selection For ◽  
Neutral Mutations

ABSTRACT Gene frequency distributions observed in large-scale surveys of species of Drosophila are shown to be incompatible with a genetic model involving neutral mutations and genetic drift alone. The data are, however, qualitatively similar to predictions based on an alternative model of natural selection for an optimal level of enzyme activity in addition to drift and mutation. The intensity of selection detected reduces the mean rate of gene substitution to less than one-quarter that expected on the neutral-allele hypothesis.

Distribution Function for Similarity Estimates

1969 ◽  
Vol 29 (3) ◽  
pp. 967-983 ◽  
Author(s):  
Goesta Ekman ◽  
Teodor Kuennapas
Keyword(s):  
Distribution Function ◽  
Large Scale ◽  
Ratio Estimation ◽  
Close Approximation ◽  
Frequency Distributions ◽  
Dimensional Scaling ◽  
Multidimensional Problems ◽  
The Mean ◽  
Mean Similarity ◽  
Binomial Function

With the increasing use of similarity analysis as a technique for the study of multidimensional problems, properties of similarity estimates deserve increasing interest. The paper reports an investigation of the inter-individual variation of similarity estimates. Data from a previous large-scale study by Kuennapas were used for this purpose. Similarity estimates were available for 378 stimulus pairs judged by 57 Ss. The standard deviation was shown to vary regularly with the mean similarity estimate. A function derived from the binomial distribution function was found to describe the trend highly satisfactorily. As a further illustration of the same principle, it was shown that the binomial function describes the frequency distributions of similarity estimates in close approximation. It is suggested that similar simple principles may describe the data obtained in experiments involving conventional uni-dimensional scaling techniques, e.g., magnitude and ratio estimation.

scholarly journals Quality Control in 3D Printing: Accuracy Analysis of 3D-Printed Models of Patient-Specific Anatomy

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1021
Author(s):  
Bernhard Dorweiler ◽  
Pia Elisabeth Baqué ◽  
Rayan Chaban ◽  
Ahmed Ghazy ◽  
Oroa Salem
Keyword(s):  
Wall Thickness ◽  
Large Scale ◽  
Fused Deposition Modeling ◽  
Vascular Anatomy ◽  
3D Models ◽  
Patient Specific ◽  
Stl File ◽  
Fused Deposition ◽  
3D Printed ◽  
The Mean

As comparative data on the precision of 3D-printed anatomical models are sparse, the aim of this study was to evaluate the accuracy of 3D-printed models of vascular anatomy generated by two commonly used printing technologies. Thirty-five 3D models of large (aortic, wall thickness of 2 mm, n = 30) and small (coronary, wall thickness of 1.25 mm, n = 5) vessels printed with fused deposition modeling (FDM) (rigid, n = 20) and PolyJet (flexible, n = 15) technology were subjected to high-resolution CT scans. From the resulting DICOM (Digital Imaging and Communications in Medicine) dataset, an STL file was generated and wall thickness as well as surface congruency were compared with the original STL file using dedicated 3D engineering software. The mean wall thickness for the large-scale aortic models was 2.11 µm (+5%), and 1.26 µm (+0.8%) for the coronary models, resulting in an overall mean wall thickness of +5% for all 35 3D models when compared to the original STL file. The mean surface deviation was found to be +120 µm for all models, with +100 µm for the aortic and +180 µm for the coronary 3D models, respectively. Both printing technologies were found to conform with the currently set standards of accuracy (<1 mm), demonstrating that accurate 3D models of large and small vessel anatomy can be generated by both FDM and PolyJet printing technology using rigid and flexible polymers.

scholarly journals Relationship between large-scale ionospheric field-aligned currents and electron/ion precipitations: DMSP observations

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Chao Xiong ◽  
Claudia Stolle ◽  
Patrick Alken ◽  
Jan Rauberg
Keyword(s):  
Time Distribution ◽  
Large Scale ◽  
Particle Flux ◽  
Particle Energy ◽  
Lower Latitude ◽  
Particle Precipitation ◽  
Data Set ◽  
The Mean ◽  
Two Parameters ◽  
Meteorological Satellite

Abstract In this study, we have derived field-aligned currents (FACs) from magnetometers onboard the Defense Meteorological Satellite Project (DMSP) satellites. The magnetic latitude versus local time distribution of FACs from DMSP shows comparable dependences with previous findings on the intensity and orientation of interplanetary magnetic field (IMF) By and Bz components, which confirms the reliability of DMSP FAC data set. With simultaneous measurements of precipitating particles from DMSP, we further investigate the relation between large-scale FACs and precipitating particles. Our result shows that precipitation electron and ion fluxes both increase in magnitude and extend to lower latitude for enhanced southward IMF Bz, which is similar to the behavior of FACs. Under weak northward and southward Bz conditions, the locations of the R2 current maxima, at both dusk and dawn sides and in both hemispheres, are found to be close to the maxima of the particle energy fluxes; while for the same IMF conditions, R1 currents are displaced further to the respective particle flux peaks. Largest displacement (about 3.5°) is found between the downward R1 current and ion flux peak at the dawn side. Our results suggest that there exists systematic differences in locations of electron/ion precipitation and large-scale upward/downward FACs. As outlined by the statistical mean of these two parameters, the FAC peaks enclose the particle energy flux peaks in an auroral band at both dusk and dawn sides. Our comparisons also found that particle precipitation at dawn and dusk and in both hemispheres maximizes near the mean R2 current peaks. The particle precipitation flux maxima closer to the R1 current peaks are lower in magnitude. This is opposite to the known feature that R1 currents are on average stronger than R2 currents.

scholarly journals The Evolution of Isochores: Evidence From SNP Frequency Distributions

Genetics ◽  
2002 ◽  
Vol 162 (4) ◽  
pp. 1805-1810 ◽  
Author(s):  
Martin J Lercher ◽  
Nick G C Smith ◽  
Adam Eyre-Walker ◽  
Laurence D Hurst
Keyword(s):  
Population Genetics ◽  
Large Scale ◽  
Gc Content ◽  
Nucleotide Composition ◽  
Compositional Variation ◽  
Mutation Bias ◽  
Single Nucleotide ◽  
Frequency Distributions ◽  
Noncoding Regions ◽  
Standard Population

AbstractThe large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume compositional equilibrium. In the first test we assume a standard population genetics model, but in the second we make no assumptions about the underlying population genetics. We apply the tests to single-nucleotide polymorphism data from noncoding regions of the human genome. Both models of neutral mutation bias fit the frequency distributions of SNPs segregating in low- and medium-GC-content regions of the genome adequately, although both suggest compositional nonequilibrium. However, neither model fits the frequency distribution of SNPs from the high-GC-content regions. In contrast, a simple population genetics model that incorporates selection or biased gene conversion cannot be rejected. The results suggest that mutation biases are not solely responsible for the compositional biases found in noncoding regions.

scholarly journals Improved Visual Localization via Graph Filtering

2021 ◽  
Vol 7 (2) ◽  
pp. 20
Author(s):  
Carlos Lassance ◽  
Yasir Latif ◽  
Ravi Garg ◽  
Vincent Gripon ◽  
Ian Reid
Keyword(s):  
Image Retrieval ◽  
Large Scale ◽  
Visual Localization ◽  
Localization Accuracy ◽  
Additional Information ◽  
Feature Representations ◽  
The Mean ◽  
Classical Image ◽  
Vision Based Localization ◽  
Improve Reliability

Vision-based localization is the problem of inferring the pose of the camera given a single image. One commonly used approach relies on image retrieval where the query input is compared against a database of localized support examples and its pose is inferred with the help of the retrieved items. This assumes that images taken from the same places consist of the same landmarks and thus would have similar feature representations. These representations can learn to be robust to different variations in capture conditions like time of the day or weather. In this work, we introduce a framework which aims at enhancing the performance of such retrieval-based localization methods. It consists in taking into account additional information available, such as GPS coordinates or temporal proximity in the acquisition of the images. More precisely, our method consists in constructing a graph based on this additional information that is later used to improve reliability of the retrieval process by filtering the feature representations of support and/or query images. We show that the proposed method is able to significantly improve the localization accuracy on two large scale datasets, as well as the mean average precision in classical image retrieval scenarios.

scholarly journals Growth and population biology of the sand-bubbler crab Scopimera crabricauda Alcock 1900 (Brachyura: Dotillidae) from the Persian Gulf, Iran

2021 ◽  
Vol 82 (1) ◽  
Author(s):  
Sana Sharifian ◽  
Vahid Malekzadeh ◽  
Ehsan Kamrani ◽  
Mohsen Safaie
Keyword(s):  
Persian Gulf ◽  
Population Biology ◽  
Slow Growth ◽  
Carapace Width ◽  
Population Data ◽  
Natural Mortality ◽  
Frequency Distributions ◽  
Iranian Coast ◽  
The Mean ◽  
The Persian Gulf

Abstract Background Dotillid crabs are introduced as one common dwellers of sandy shores. We studied the ecology and growth of the sand bubbler crab Scopimera crabricauda Alcock, 1900, in the Persian Gulf, Iran. Crabs were sampled monthly by excavating nine quadrats at three intertidal levels during spring low tides from January 2016 to January 2017. Results Population data show unimodal size-frequency distributions in both sexes. The Von Bertalanffy function was calculated at CWt = 8.76 [1 − exp (− 0.56 (t + 0.39))], CWt = 7.90 [1 − exp (− 0.59 (t + 0.40))] and CWt = 9.35 [1 − exp (− 0.57 (t + 0.41))] for males, females, and both sexes, respectively. The life span appeared to be 5.35, 5.07, and 5.26 years for males, females, and both sexes, respectively. The cohorts were identified as two age continuous groups, with the mean model carapace width 5.39 and 7.11 mm for both sexes. The natural mortality (M) coefficients stood at 1.72 for males, 1.83 for females, and 1.76 years−1 for both sexes, respectively. The overall sex ratio (1:0.4) was significantly different from the expected 1:1 proportion with male-biased. Recruitment occurred with the highest number of annual pulse once a year during the summer. Conclusions The results, which show slow growth, emphasize the necessity of proper management for the survival of the stock of S. crabricauda on the Iranian coast of the Persian Gulf.

The Age of Nonsynonymous and Synonymous Mutations in Animal mtDNA and Implications for the Mildly Deleterious Theory

Genetics ◽  
1999 ◽  
Vol 153 (1) ◽  
pp. 497-506 ◽  
Author(s):  
Rasmus Nielsen ◽  
Daniel M Weinreich
Keyword(s):  
Dna Sequences ◽  
Purifying Selection ◽  
Data Sets ◽  
Deleterious Mutations ◽  
Synonymous Mutations ◽  
Weak Evidence ◽  
Mitochondrial Data ◽  
The Mean ◽  
Excess Number ◽  
Neutral Mutations

Abstract McDonald/Kreitman tests performed on animal mtDNA consistently reveal significant deviations from strict neutrality in the direction of an excess number of polymorphic nonsynonymous sites, which is consistent with purifying selection acting on nonsynonymous sites. We show that under models of recurrent neutral and deleterious mutations, the mean age of segregating neutral mutations is greater than the mean age of segregating selected mutations, even in the absence of recombination. We develop a test of the hypothesis that the mean age of segregating synonymous mutations equals the mean age of segregating nonsynonymous mutations in a sample of DNA sequences. The power of this age-of-mutation test and the power of the McDonald/Kreitman test are explored by computer simulations. We apply the new test to 25 previously published mitochondrial data sets and find weak evidence for selection against nonsynonymous mutations.

scholarly journals Mesoscale Features Associated with Tropical Cyclone Formations in the Western North Pacific

2008 ◽  
Vol 136 (6) ◽  
pp. 2006-2022 ◽  
Author(s):  
Cheng-Shang Lee ◽  
Kevin K. W. Cheung ◽  
Jenny S. N. Hui ◽  
Russell L. Elsberry
Keyword(s):  
Tropical Cyclone ◽  
North Pacific ◽  
Western North Pacific ◽  
Large Scale ◽  
North Pacific Ocean ◽  
Deep Convection ◽  
Mesoscale Convective System ◽  
Convective System ◽  
Synoptic Patterns ◽  
The Mean

Abstract The mesoscale features of 124 tropical cyclone formations in the western North Pacific Ocean during 1999–2004 are investigated through large-scale analyses, satellite infrared brightness temperature (TB), and Quick Scatterometer (QuikSCAT) oceanic wind data. Based on low-level wind flow and surge direction, the formation cases are classified into six synoptic patterns: easterly wave (EW), northeasterly flow (NE), coexistence of northeasterly and southwesterly flow (NE–SW), southwesterly flow (SW), monsoon confluence (MC), and monsoon shear (MS). Then the general convection characteristics and mesoscale convective system (MCS) activities associated with these formation cases are studied under this classification scheme. Convection processes in the EW cases are distinguished from the monsoon-related formations in that the convection is less deep and closer to the formation center. Five characteristic temporal evolutions of the deep convection are identified: (i) single convection event, (ii) two convection events, (iii) three convection events, (iv) gradual decrease in TB, and (v) fluctuating TB, or a slight increase in TB before formation. Although no dominant temporal evolution differentiates cases in the six synoptic patterns, evolutions ii and iii seem to be the common routes taken by the monsoon-related formations. The overall percentage of cases with MCS activity at multiple times is 63%, and in 35% of cases more than one MCS coexisted. Most of the MC and MS cases develop multiple MCSs that lead to several episodes of deep convection. These two patterns have the highest percentage of coexisting MCSs such that potential interaction between these systems may play a role in the formation process. The MCSs in the monsoon-related formations are distributed around the center, except in the NE–SW cases in which clustering of MCSs is found about 100–200 km east of the center during the 12 h before formation. On average only one MCS occurs during an EW formation, whereas the mean value is around two for the other monsoon-related patterns. Both the mean lifetime and time of first appearance of MCS in EW are much shorter than those developed in other synoptic patterns, which indicates that the overall formation evolution in the EW case is faster. Moreover, this MCS is most likely to be found within 100 km east of the center 12 h before formation. The implications of these results to internal mechanisms of tropical cyclone formation are discussed in light of other recent mesoscale studies.

scholarly journals Well-Being of Healthcare Workers and the General Public during the COVID-19 Pandemic in Vietnam: An Online Survey

2021 ◽  
Vol 18 (9) ◽  
pp. 4737
Author(s):  
Tuyen Dinh Hoang ◽  
Robert Colebunders ◽  
Joseph Nelson Siewe Fodjo ◽  
Nhan Phuc Thanh Nguyen ◽  
Trung Dinh Tran ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Large Scale ◽  
Online Survey ◽  
Preventive Measures ◽  
Vaccine Coverage ◽  
Health Sector ◽  
Well Being ◽  
Multivariate Logistic Regression Model ◽  
The Mean ◽  
Restrictive Measures

The COVID-19 pandemic and associated restrictive measures implemented may considerably affect people’s lives. This study aimed to assess the well-being of Vietnamese people after COVID-19 lockdown measures were lifted and life gradually returned to normal. An online survey was organized from 21 to 25 April 2020 among Vietnamese residents aged 18 and over. The survey was launched by the Hue University of Medicine and Pharmacy. The WHO-5 Well-Being Index (scored 0–25) was used to score participants’ well-being. A multivariate logistic regression model was used to determine the predictors of well-being. A total of 1922 responses were analyzed (mean age: 31 years; 30.5% male; 88.2% health professionals or students in the health sector). The mean well-being score was 17.35 ± 4.97. Determinants of a high well-being score (≥13) included older age, eating healthy food, practicing physical exercise, working from home, and adhering to the COVID-19 preventive measures. Female participants, persons worried about their relatives’ health, and smokers were more likely to have a low well-being score. In conclusion, after the lockdown measures were lifted, the Vietnamese have people continued to follow COVID-19 preventive measures, and most of them scored high on the well-being scale. Waiting to achieve large-scale COVID-19 vaccine coverage, promoting preventive COVID-19 measures remains important, together with strategies to guarantee the well-being of the Vietnamese people.

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