scholarly journals THE RELATIVE INFLUENCE OF SEX OF PROGENY ON THE LETHAL EXPRESSION OF THE SONLESS GENE IN DROSOPHILA MELANOGASTER

Genetics ◽  
1972 ◽  
Vol 72 (2) ◽  
pp. 293-296
Author(s):  
James J Colaianne ◽  
A E Bell
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Ratio ◽  
Y Chromosome ◽  
Gene Action ◽  
Relative Influence ◽  
Lethal Gene ◽  
Interaction Studies ◽  
New Findings

ABSTRACT The sex-linked maternally influenced lethal gene, sonless (snl), in D. melanogaster was shown to affect the survival of daughters as well as sons of snl/snl mothers but to a lesser degree. Interaction studies of sonless with the sex altering mutants transformer (tra) and doublesex (dsx) revealed that any alteration toward increased masculinity of progeny from snl/snl females reduced their zygotic viability, independent of snl dosage or Y chromosome presence or absence. Possible implications of these results are discussed and the original gene action hypothesis for snl is extended to incorporate these new findings.—Sonless is non-allelic but closely linked to rudimentary (r) and fused (fu), two mutants with similar sex-ratio patterns.

scholarly journals Drosophila melanogaster male germ line-specific transcripts with autosomal and Y-linked genes.

Genetics ◽  
1993 ◽  
Vol 134 (1) ◽  
pp. 293-308 ◽  
Author(s):  
S R Russell ◽  
K Kaiser
Keyword(s):  
Drosophila Melanogaster ◽  
Y Chromosome ◽  
Germ Line ◽  
Stop Codon ◽  
Chromatin Condensation ◽  
Sperm Chromatin ◽  
Autosomal Gene ◽  
Cdna Clones ◽  
Autosomal Locus ◽  
Functional Protein

Abstract We have identified of set of related transcripts expressed in the germ line of male Drosophila melanogaster. Surprisingly, while one of the corresponding genes is autosomal the remainder are located on the Y chromosome. The autosomal locus, at 77F on chromosome arm 3L, corresponds to the previously described transcription unit 18c, located in the first intron of the gene for an RI subunit of cAMP-dependent protein kinase. The Y chromosome copies have been mapped to region h18-h19 on the cytogenetic map of the Y outside of any of the regions required for male fertility. In contrast to D. melanogaster, where Y-linked copies were found in nine different wild-type strains, no Y-linked copies were found in sibling species. Several apparently Y-derived cDNA clones and one Y-linked genomic clone have been sequenced. The Y-derived genomic DNA shares the same intron/exon structure as the autosomal copy as well as related flanking sequences suggesting that it transposed to the Y from the autosomal locus. However, this particular Y-linked copy cannot encode a functional polypeptide due to a stop codon at amino acid position 72. Divergence among five different cDNA clones ranges from 1.5 to 6% and includes a large number of third position substitutions. We have not yet obtained a full-length cDNA from a Y-linked gene and therefore cannot conclude that the D. melanogaster Y chromosome contains functional protein-coding genes. The autosomal gene encodes a predicted polypeptide with 45% similarity to histones of the H5 class and more limited similarity to cysteine-rich protamines. This protein may be a distant relative of the histone H1 family perhaps involved in sperm chromatin condensation.

scholarly journals Polycomb Assemblies Multitask to Regulate Transcription

Epigenomes ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. 12 ◽  
Author(s):  
Miguel Vidal
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Transcriptional Control ◽  
Catalytic Properties ◽  
Integrated Approach ◽  
Gene Repression ◽  
Developmental Studies ◽  
Topological Domains ◽  
Developmental Transitions ◽  
New Findings

The Polycomb system is made of an evolutionary ancient group of proteins, present throughout plants and animals. Known initially from developmental studies with the fly Drosophila melanogaster, they were associated with stable sustainment of gene repression and maintenance of cell identity. Acting as multiprotein assemblies with an ability to modify chromatin, through chemical additions to histones and organization of topological domains, they have been involved subsequently in control of developmental transitions and in cell homeostasis. Recent work has unveiled an association of Polycomb components with transcriptionally active loci and the promotion of gene expression, in clear contrast with conventional recognition as repressors. Focusing on mammalian models, I review here advances concerning roles in transcriptional control. Among new findings highlighted is the regulation of their catalytic properties, recruiting to targets, and activities in chromatin organization and compartmentalization. The need for a more integrated approach to the study of the Polycomb system, given its fundamental complexity and its adaptation to cell context, is discussed.

Interspecific hybridization between Drosophila species group melanogaster sibling species: isozymic patterns and reproductive relationships

Genome ◽  
1989 ◽  
Vol 32 (1) ◽  
pp. 146-154 ◽  
Author(s):  
G. N. Goulielmos ◽  
S. N. Alahiotis
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Ratio ◽  
Interspecific Hybrids ◽  
Aldehyde Oxidase ◽  
Species Group ◽  
Fitness Components ◽  
Phosphogluconate Dehydrogenase ◽  
Evolutionary Changes ◽  
Fertile Hybrids ◽  
Male Genital

In spite of previous consensus that no F1 fertile hybrids (of both sexes) could be produced between any mating combination of Drosophila melanogaster, D. simulans, and D. mauritiana, the present data indicate that such hybrids were obtained. Thus, some crosses between D. mauritiana females and D. simulans or D. melanogaster males yield F1 fertile hybrids (of both sexes) which have been named Masi (or Masi-2 and Masi-3) and Mame, respectively. Electrophoretic studies, using the species-diagnostic genes for 6-phosphogluconate dehydrogenase, alcohol dehydrogenase, and aldehyde oxidase (6-Pgd, Adh, and Aldox, respectively), were used to investigate the hybrid status, taking into consideration (i) their reproductive relationships, (ii) the coexistence of electromorphs from different species in the same hybrid, within the same generation, and (iii) the expression of the above electromorphs in the hybrids as well as in progeny from backcrosses, where unexpected irregularities and abnormalities were observed. These interspecific hybrids have been kept in our laboratory (as stocks) for 50 generations, to date, and have also been tested for various characteristics that contributed to the verification of their hybrid status (mating abilities, enzyme activities, hybrid sex ratio, the morphology of male genital arches and other fitness components). The finding of major genetic phenomena (e.g., allozymic repression) in these hybrid genomes gives some idea of the nature of events that could be associated with strong evolutionary changes, thus controlling speciation processes.Key words: Drosophila, electrophoresis, electromorphs, interspecific hybrids.

Genomic and cytological analysis of the Y chromosome of Drosophila melanogaster: telomere-derived sequences at internal regions

Chromosoma ◽  
2004 ◽  
Vol 113 (6) ◽  
pp. 295-304 ◽  
Author(s):  
José P. Abad ◽  
Beatriz de Pablos ◽  
Marta Agudo ◽  
Isabel Molina ◽  
Giovanna Giovinazzo ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Y Chromosome ◽  
Cytological Analysis

scholarly journals DO ODOCOILEUS VIRGINIANUS MALES PRODUCE Y-CHROMOSOME-BIASED EJACULATES? IMPLICATIONS FOR ADAPTIVE SEX RATIO THEORIES

2004 ◽  
Vol 85 (4) ◽  
pp. 768-773 ◽  
Author(s):  
Randy W. DeYoung ◽  
Lisa I. Muller ◽  
Stephen Demarais ◽  
H. David Guthrie ◽  
Glenn R. Welch ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Odocoileus Virginianus ◽  
Y Chromosome

scholarly journals A fertility region on the Y chromosome of Drosophila melanogaster encodes a dynein microtubule motor

1993 ◽  
Vol 90 (23) ◽  
pp. 11132-11136 ◽  
Author(s):  
J Gepner ◽  
T S Hays
Keyword(s):  
Drosophila Melanogaster ◽  
Y Chromosome ◽  
Heavy Chain ◽  
Male Fertility ◽  
Chromosome Region ◽  
Cytoplasmic Dynein ◽  
Dynein Heavy Chain ◽  
Microtubule Motor ◽  
Hydrolysis Of

A clone encoding a portion of the highly conserved ATP-binding domain of a dynein heavy-chain polypeptide was mapped to a region of the Drosophila melanogaster Y chromosome. Dyneins are large multisubunit enzymes that utilize the hydrolysis of ATP to move along microtubules. They were first identified as the motors that provide the force for flagellar and ciliary bending. Seven different dynein heavy-chain genes have been identified in D. melanogaster by PCR. In the present study, we demonstrate that one of the dynein genes, Dhc-Yh3, is located in Y chromosome region h3, which is contained within kl-5, a locus required for male fertility. The PCR clone derived from Dhc-Yh3 is 85% identical to the corresponding region of the beta heavy chain of sea urchin flagellar dynein but only 53% identical to a cytoplasmic dynein heavy chain from Drosophila. In situ hybridization to Drosophila testes shows Dhc-Yh3 is expressed in wild-type males but not in males missing the kl-5 region. These results are consistent with the hypothesis that the Y chromosome is needed for male fertility because it contains conventional genes that function during spermiogenesis.

Calving sex ratio as related to the predicted Y-chromosome-bearing spermatozoa ratio in bull ejaculates

2007 ◽  
Vol 67 (3) ◽  
pp. 563-571 ◽  
Author(s):  
John E. Chandler ◽  
Tara M. Taylor ◽  
Anita L. Canal ◽  
Richard K. Cooper ◽  
E. Barry Moser ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Y Chromosome

Cytological and genetic analysis of the Y chromosome of Drosophila melanogaster

Chromosoma ◽  
1983 ◽  
Vol 88 (5) ◽  
pp. 349-373 ◽  
Author(s):  
Maurizio Gatti ◽  
Sergio Pimpinelli
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Analysis ◽  
Y Chromosome
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