scholarly journals BRIDGE AND FRAGMENT ABERRATIONS IN PODOPHYLLUM PELTATUM

Genetics ◽  
1966 ◽  
Vol 53 (1) ◽  
pp. 55-63
Author(s):  
Lester J Newman
Keyword(s):  
Podophyllum Peltatum

Carpeloid Stamens of Podophyllum peltatum

1926 ◽  
Vol 82 (3) ◽  
pp. 329-332 ◽  
Author(s):  
M. Louise Sawyer
Keyword(s):  
Podophyllum Peltatum

Evaluation of Podophyllum peltatum Accessions for Podophyllotoxin Production

Planta Medica ◽  
2002 ◽  
Vol 68 (4) ◽  
pp. 341-344 ◽  
Author(s):  
Rita M. Moraes ◽  
Ebru Bedir ◽  
Holly Barrett ◽  
Charles Burandt Jr ◽  
Camilo Canel ◽  
...  
Keyword(s):  
Podophyllum Peltatum

Effects of Podophyllum peltatum compounds in various preparations and dilutions on human neutrophil functions in vitro

1997 ◽  
Vol 86 (01) ◽  
pp. 16-26 ◽  
Author(s):  
S. Chirumbolo ◽  
A. Conforti ◽  
S. Lussignoli ◽  
H. Metelmann ◽  
P. Bellavite
Keyword(s):  
Respiratory Burst ◽  
Cellular Adhesion ◽  
Final Concentration ◽  
Active Principle ◽  
Neutrophil Granulocytes ◽  
Podophyllum Peltatum ◽  
Coated Surface ◽  
High Doses ◽  
Formyl Peptides

AbstractHuman blood neutrophil granulocytes (neutrophils) treated with Podophyllum peltatum L.-derived compounds exhibited an enhanced oxidative response to subsequent challenge with bacterial formyl peptides. This priming effect was concerned with superoxide anion (O2 −) release (respiratory burst). The phenomenon was observed with a potentized preparation containing, among other things, podophyllum extract (Podophyllum compositum), with Podophyllum 4x (final concentration of active principle about 0.025 μg/ml), whereas enhancement of O2 − release was not caused by homoeopathic Podophyllum 12x or other components of the complex homoeopathic preparation. Purified podophyllotoxin had the same effect at doses of 0.1–10 μg/ml, whereas doses higher than 100 μg/ml of podophyllotoxin inhibited the respiratory burst, so that pure toxin showed a typical bi-phasic dose-response curve. Similar effects were obtained with purified colchicine (1–1000 μg/ml), a microtubule-disrupting agent. No priming by a Podophyllum-derived compound was observed on neutrophils stimulated with 50 ng/ml phorbol ester. Further, both potentized podophyllum-derived compounds and pure podophyllotoxin-inhibited cellular adhesion to the serum-coated surface of culture microplates. These results show that low potencies of a drug extract have specific stimulating effects on the activation of neutrophil metabolism. The same stimulating effects are also caused by low doses of the active principle of the drug, which is an inhibitor when used at high doses.

High Yield of Podophyllotoxin from Leaves of Podophyllum peltatum by In situ Conversion of Podophyllotoxin 4-O-β-D-Glucopyranoside

Planta Medica ◽  
2001 ◽  
Vol 67 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Camilo Canel ◽  
Franck E. Dayan ◽  
Markus Ganzera ◽  
Ikhlas A. Khan ◽  
Agnes Rimando ◽  
...  
Keyword(s):  
High Yield ◽  
Podophyllum Peltatum
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