scholarly journals Genomic Landscape of Methylation Islands in Hymenopteran Insects

2018 ◽  
Vol 10 (10) ◽  
pp. 2766-2776 ◽  
Author(s):  
Hyeonsoo Jeong ◽  
Xin Wu ◽  
Brandon Smith ◽  
Soojin V Yi
Keyword(s):  
Genomic Landscape ◽  
Hymenopteran Insects

Genomic landscape of MDS/CMML associated with systemic inflammatory and autoimmune disease

Leukemia ◽  
2021 ◽  
Author(s):  
Lin-Pierre Zhao ◽  
Maxime Boy ◽  
Célia Azoulay ◽  
Emmanuelle Clappier ◽  
Marie Sébert ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Genomic Landscape

scholarly journals Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xuan Zong ◽  
Ying Zhang ◽  
Xinxin Peng ◽  
Dongyan Cao ◽  
Mei Yu ◽  
...  
Keyword(s):  
Copy Number Alteration ◽  
Germ Cell Tumors ◽  
Gonadal Development ◽  
Yolk Sac ◽  
Mutational Signatures ◽  
Whole Exome ◽  
Genomic Landscape ◽  
Yolk Sac Tumors ◽  
Molecular Aberrations

AbstractYolk sac tumors (YSTs) are a major histological subtype of malignant ovarian germ cell tumors with a relatively poor prognosis. The molecular basis of this disease has not been thoroughly characterized at the genomic level. Here we perform whole-exome and RNA sequencing on 41 clinical tumor samples from 30 YST patients, with distinct responses to cisplatin-based chemotherapy. We show that microsatellite instability status and mutational signatures are informative of chemoresistance. We identify somatic driver candidates, including significantly mutated genes KRAS and KIT and copy-number alteration drivers, including deleted ARID1A and PARK2, and amplified ZNF217, CDKN1B, and KRAS. YSTs have very infrequent TP53 mutations, whereas the tumors from patients with abnormal gonadal development contain both KRAS and TP53 mutations. We further reveal a role of OVOL2 overexpression in YST resistance to cisplatin. This study lays a critical foundation for understanding key molecular aberrations in YSTs and developing related therapeutic strategies.

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