scholarly journals Mitochondrial Genome Rearrangements in Glomus Species Triggered by Homologous Recombination between Distinct mtDNA Haplotypes

2013 ◽  
Vol 5 (9) ◽  
pp. 1628-1643 ◽  
Author(s):  
Denis Beaudet ◽  
Yves Terrat ◽  
Sébastien Halary ◽  
Ivan Enrique de la Providencia ◽  
Mohamed Hijri
Keyword(s):  
Homologous Recombination ◽  
Mitochondrial Genome ◽  
Genome Rearrangements ◽  
Mtdna Haplotypes ◽  
Glomus Species

scholarly journals Partially local three-way alignments and the sequence signatures of mitochondrial genome rearrangements

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Marwa Al Arab ◽  
Matthias Bernt ◽  
Christian Höner zu Siederdissen ◽  
Kifah Tout ◽  
Peter F. Stadler
Keyword(s):  
Mitochondrial Genome ◽  
Genome Rearrangements ◽  
Sequence Signatures

Intragenomic recombination in the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans

Microbiology ◽  
2005 ◽  
Vol 151 (10) ◽  
pp. 3371-3379 ◽  
Author(s):  
Kirsten T. Eriksen ◽  
Dorte Haubek ◽  
Knud Poulsen
Keyword(s):  
Homologous Recombination ◽  
Dna Fingerprinting ◽  
Restriction Enzyme ◽  
Multilocus Sequence Typing ◽  
African Descent ◽  
Rflp Analysis ◽  
Aggressive Periodontitis ◽  
Genome Rearrangements ◽  
Actinobacillus Actinomycetemcomitans

The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans is strongly associated with aggressive periodontitis in adolescents of African descent. DNA fingerprinting using the frequently cutting restriction enzyme MspI and multilocus sequence typing (MLST) showed that five strains of this clone were genetically virtually identical, although ribotyping of the six rrn genes and EcoRI RFLP analysis of the seven IS150-like elements revealed differences. PCR analyses demonstrated that these multi-copy sequences are subject to intragenomic homologous recombination, resulting in translocations or large inversions. The genome rearrangements were reflected in differences among 25 strains representing the JP2 clone in DNA fingerprinting using the rare-cutting restriction enzyme XhoI and resolved by PFGE. XhoI DNA fingerprinting provides a tool for studying local epidemiology, including transmission of this particularly pathogenic clone of A. actinomycetemcomitans.

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