scholarly journals Ongoing GC-Biased Evolution Is Widespread in the Human Genome and Enriched Near Recombination Hot Spots

2011 ◽  
Vol 3 ◽  
pp. 614-626 ◽  
Author(s):  
Sol Katzman ◽  
John A. Capra ◽  
David Haussler ◽  
Katherine S. Pollard
Keyword(s):  
Human Genome ◽  
Hot Spots ◽  
Recombination Hot Spots

scholarly journals Meiotic recombination hot spots and human DNA diversity

2004 ◽  
Vol 359 (1441) ◽  
pp. 141-152 ◽  
Author(s):  
Alec J. Jeffreys ◽  
J. Kim Holloway ◽  
Liisa Kauppi ◽  
Celia A. May ◽  
Rita Neumann ◽  
...  
Keyword(s):  
Human Genome ◽  
Meiotic Recombination ◽  
Hot Spots ◽  
Haplotype Diversity ◽  
Mendelian Inheritance ◽  
Human Diversity ◽  
Fundamental Information ◽  
Recombination Hot Spots ◽  
Sperm Typing ◽  
Very High

Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine–scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome. These hot spots provide fundamental information on processes of human crossover and gene conversion, as well as evidence that they can violate basic rules of Mendelian inheritance.

scholarly journals The Relationship Between Microsatellite Polymorphism and Recombination Hot Spots in the Human Genome

2008 ◽  
Vol 25 (12) ◽  
pp. 2579-2587 ◽  
Author(s):  
M. Brandstrom ◽  
A. T. Bagshaw ◽  
N. J. Gemmell ◽  
H. Ellegren
Keyword(s):  
Human Genome ◽  
Hot Spots ◽  
Microsatellite Polymorphism ◽  
Recombination Hot Spots ◽  
The Relationship

scholarly journals A Highly Polymorphic Meiotic Recombination Mouse Hot Spot Exhibits Incomplete Repair

2007 ◽  
Vol 27 (20) ◽  
pp. 7053-7062 ◽  
Author(s):  
Philippe R. J. Bois
Keyword(s):  
Human Genome ◽  
Meiotic Recombination ◽  
Hot Spots ◽  
Hot Spot ◽  
Inbred Strains ◽  
Heteroduplex Dna ◽  
Mammalian Genomes ◽  
Recombination Hot Spots ◽  
Wild House Mouse ◽  
Mature Spermatozoa

ABSTRACT The recent mapping of recombination hot spots in the human genome has demonstrated that crossover is a nonrandom process that occurs at well-defined positions along chromosomes. However, the mechanisms that direct hot-spot turnover in complex mammalian genomes are poorly understood. Analyses of the human genome are impaired by the inability to genetically dissect and molecularly manipulate recombinogenic regions to test their roles in regulating hot spots. Here, using the BXD recombinant inbred strains as a crossover library, three new recombination hot spots have been identified on mouse chromosome 19. Analyses of a highly polymorphic recombination hot spot (HS22) revealed that approximately 4% of recombinant molecules display complex and incomplete repair with discontinuous conversion tracts, as well as persistent heteroduplex DNA at crossover sites in mature spermatozoa. Also, sequence analysis of the wild house mouse revealed instability at the center of this hot spot. This suggests that complete repair is not required for completion of mammalian meiosis, a scenario that leaves duplex DNA containing mismatches at crossover sites.

scholarly journals The Translin Ring Specifically Recognizes DNA Ends at Recombination Hot Spots in the Human Genome

1997 ◽  
Vol 272 (17) ◽  
pp. 11402-11407 ◽  
Author(s):  
Masataka Kasai ◽  
Takao Matsuzaki ◽  
Katsuo Katayanagi ◽  
Akira Omori ◽  
Richard T. Maziarz ◽  
...  
Keyword(s):  
Human Genome ◽  
Hot Spots ◽  
Recombination Hot Spots ◽  
Dna Ends

Small grains as recombination hot spots in perovskite solar cells

Matter ◽  
2021 ◽  
Author(s):  
Qingzhi An ◽  
Fabian Paulus ◽  
David Becker-Koch ◽  
Changsoon Cho ◽  
Qing Sun ◽  
...  
Keyword(s):  
Solar Cells ◽  
Hot Spots ◽  
Perovskite Solar Cells ◽  
Small Grains ◽  
Recombination Hot Spots

High resolution localization of recombination hot spots using sperm typing

1994 ◽  
Vol 7 (3) ◽  
pp. 420-424 ◽  
Author(s):  
Rene Hubert ◽  
Marcy MacDonald ◽  
James Gusella ◽  
Norman Arnheim
Keyword(s):  
High Resolution ◽  
Hot Spots ◽  
Recombination Hot Spots ◽  
Sperm Typing

scholarly journals Effects of Temperature on the Meiotic Recombination Landscape of the Yeast Saccharomyces cerevisiae

mBio ◽  
2017 ◽  
Vol 8 (6) ◽  
Author(s):  
Ke Zhang ◽  
Xue-Chang Wu ◽  
Dao-Qiong Zheng ◽  
Thomas D. Petes
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Conversion ◽  
Meiotic Recombination ◽  
Hot Spots ◽  
Genetic Maps ◽  
Dna Breaks ◽  
Low Levels ◽  
C 30 ◽  
Recombination Hot Spots ◽  
In Cells

ABSTRACT Although meiosis in warm-blooded organisms takes place in a narrow temperature range, meiosis in many organisms occurs over a wide variety of temperatures. We analyzed the properties of meiosis in the yeast Saccharomyces cerevisiae in cells sporulated at 14°C, 30°C, or 37°C. Using comparative-genomic-hybridization microarrays, we examined the distribution of Spo11-generated meiosis-specific double-stranded DNA breaks throughout the genome. Although there were between 300 and 400 regions of the genome with high levels of recombination (hot spots) observed at each temperature, only about 20% of these hot spots were found to have occurred independently of the temperature. In S. cerevisiae , regions near the telomeres and centromeres tend to have low levels of meiotic recombination. This tendency was observed in cells sporulated at 14°C and 30°C, but not at 37°C. Thus, the temperature of sporulation in yeast affects some global property of chromosome structure relevant to meiotic recombination. Using single-nucleotide polymorphism (SNP)-specific whole-genome microarrays, we also examined crossovers and their associated gene conversion events as well as gene conversion events that were unassociated with crossovers in all four spores of tetrads obtained by sporulation of diploids at 14°C, 30°C, or 37°C. Although tetrads from cells sporulated at 30°C had slightly (20%) more crossovers than those derived from cells sporulated at the other two temperatures, spore viability was good at all three temperatures. Thus, despite temperature-induced variation in the genetic maps, yeast cells produce viable haploid products at a wide variety of sporulation temperatures. IMPORTANCE In the yeast Saccharomyces cerevisiae , recombination is usually studied in cells that undergo meiosis at 25°C or 30°C. In a genome-wide analysis, we showed that the locations of genomic regions with high and low levels of meiotic recombination (hot spots and cold spots, respectively) differed dramatically in cells sporulated at 14°C, 30°C, and 37°C. Thus, in yeast, and likely in other non-warm-blooded organisms, genetic maps are strongly affected by the environment.

scholarly journals Genome-wide identification of meiotic recombination hot spots detected by SLAF in peanut (Arachis hypogaea L.)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaohua Wang ◽  
Ping Xu ◽  
Yan Ren ◽  
Liang Yin ◽  
Shuangling Li ◽  
...  
Keyword(s):  
Arachis Hypogaea ◽  
Meiotic Recombination ◽  
Hot Spots ◽  
Genome Wide ◽  
Arachis Hypogaea L ◽  
Recombination Hot Spots
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