scholarly journals Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure

2012 ◽  
Vol 33 (18) ◽  
pp. 2317-2324 ◽  
Author(s):  
Alexandre Mebazaa ◽  
Griet Vanpoucke ◽  
Gregoire Thomas ◽  
Katleen Verleysen ◽  
Alain Cohen-Solal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Decompensated Heart Failure ◽  
Diagnostic Biomarkers ◽  
Disease Identification ◽  
Acutely Decompensated Heart Failure ◽  
Plasma Proteomics

scholarly journals P803 Myocardial work in acutely decompensated heart failure patients differs between HFrEF and HFpEF

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
F Sahiti ◽  
C Morbach ◽  
C Henneges ◽  
M Hanke ◽  
R Ludwig ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Ejection Fraction ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Decompensated Heart Failure ◽  
Left Ventricular ◽  
Future Research ◽  
Lv Function ◽  
Acutely Decompensated Heart Failure

Abstract OnBehalf AHF Registry Background & Aim A novel echocardiographic method to non-invasively determine left ventricular (LV) myocardial work (MyW) based on speckle-tracking derived longitudinal strain and blood pressure has recently been validated against invasive reference measurements. MyW is considered less load-dependent than LV ejection fraction (EF) and LV longitudinal strain. We investigated MyW indices in patients with reduced ejection fraction (LVEF <40%; HFrEF) and patients with preserved ejection fraction (LVEF ≥50%, HFpEF) admitted for acutely decompensated heart failure (AHF). Methods The AHF registry is a monocentric prospective follow-up study that comprehensively phenotypes consecutive patients hospitalized for AHF. Echocardiography was performed on the day of admission. MyW assessment was performed off-line using EchoPAC (GE, version 202). Here we present MyW indices and performed two-sided t-tests to analyze differences in numerical baseline covariates. Results We analyzed the echocardiograms of 94 AHF patients (72 ± 10 years; 36% female). 46 patients (49%) had an LVEF <40%, while 48 patients (51%) presented with LVEF ≥50%. HFrEF patients were younger, less often female, and hat lower blood pressure (table). Consistent with lower LVEF, HFrEF patients had less negative global longitudinal strain and lower global constructive work, when compared to HFpEF patients. Since HFrEF patients also had higher global wasted work, this yielded a lower myocardial work efficiency compared to HFpEF patients (table). Conclusions This analysis in patients with AHF exhibited marked differences in MyW indices according to subgroups with HFrEF and HFpEF, thus adding information to the classical measures of LV function. Future research has to determine whether constructive and/or wasted MyW are valuable diagnostic or therapeutic targets in patients with AHF. Abstract P803 Figure.

scholarly journals Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

2012 ◽  
Vol 164 (5) ◽  
pp. 763-770.e3 ◽  
Author(s):  
Kalkidan Bishu ◽  
Anita Deswal ◽  
Horng H. Chen ◽  
Martin M. LeWinter ◽  
Gregory D. Lewis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Decompensated Heart Failure ◽  
Reduced Ejection Fraction ◽  
Acutely Decompensated Heart Failure
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