scholarly journals Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients

2012 ◽  
Vol 33 (16) ◽  
pp. 2088-2097 ◽  
Author(s):  
L. C. van Vark ◽  
M. Bertrand ◽  
K. M. Akkerhuis ◽  
J. J. Brugts ◽  
K. Fox ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Angiotensin Converting Enzyme ◽  
Randomized Clinical Trials ◽  
Enzyme Inhibitors ◽  
Meta Analysis ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

scholarly journals Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

2020 ◽  
Vol 33 (3) ◽  
pp. 129-132
Author(s):  
Andre Feldman ◽  
Guilherme D’Andréa Saba Arruda ◽  
Olga Ferreira de Souza
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Randomized Study ◽  
Renin Angiotensin System ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Target Cells ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

COVID-19 is a new disease caused by the Sars-CoV-2 virus and the vast majority of patients have symptoms similar to a flu-like syndrome. A small portion of those infected ends up being hospitalized and may develop with the most severe presentation of the disease. Data from Chinese series report that hypertension appears to be a condition that imposes a greater risk of unfavorable evolution of patients. Some studies have reported that Sars-CoV-2 uses the angiotensin-converting enzyme to access its target cells. There are theories that differ about the protective or harmful role that drugs that act in the renin angiotensin aldosterone system in these patients. A British study suggests that patients using angiotensin-converting enzyme inhibitors had a lower incidence of severe forms of the disease. Another study carried out a retrospective and multicenter analysis showing that mortality was lower in the group that had used the drugs when compared to the other group (3,7 vs. 9,8%; p=0,01). The various hypotheses raised through pathophysiology are not yet able to really predict the best course of action for patients using drugs that act on the renin angiotensin system. Thus, a randomized study becomes important to try to answer definitively and with a high degree of reliability to this question.

Angiotensin-converting-enzyme inhibitors in hemodynamic congestion: a meta-analysis of early studies

2019 ◽  
Vol 108 (11) ◽  
pp. 1240-1248 ◽  
Author(s):  
Alexander Jobs ◽  
Amr Abdin ◽  
Suzanne de Waha-Thiele ◽  
Ingo Eitel ◽  
Holger Thiele ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Meta Analysis ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors
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