scholarly journals Interleukin-1  levels, pain intensity, and tooth movement using two different magnitudes of continuous orthodontic force

2010 ◽  
Vol 32 (5) ◽  
pp. 596-601 ◽  
Author(s):  
S. Luppanapornlarp ◽  
T. S. Kajii ◽  
R. Surarit ◽  
J. Iida
Keyword(s):  
Pain Intensity ◽  
Tooth Movement ◽  
Interleukin 1 ◽  
Orthodontic Force

scholarly journals Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

2015 ◽  
Vol 86 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Chidchanok Leethanakul ◽  
Sumit Suamphan ◽  
Suwanna Jitpukdeebodintra ◽  
Udom Thongudomporn ◽  
Chairat Charoemratrote
Keyword(s):  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Orthodontic Tooth Movement ◽  
Enzyme Linked Immunosorbent Assay ◽  
Orthodontic Force ◽  
Electric Toothbrush ◽  
Experimental Canine ◽  
Crevicular Fluid ◽  
Canine Distalization

ABSTRACT Objectives:  To investigate the effects of application of vibratory stimuli on interleukin (IL)–1β secretion during maxillary canine distalization. Materials and Methods:  Split-mouth design study in 15 subjects (mean age, 22.9 years; range 19–25 years) whose bilateral maxillary first premolars were extracted with subsequent canine distalization. On the experimental side, light force (60 g) was applied to the canine for 3 months in combination with vibratory stimuli provided using an electric toothbrush 15 minutes a day for 2 months; only orthodontic force was applied to the contralateral control canine. Gingival crevicular fluid (GCF) was collected from the mesial and distal sides of each canine at each monthly appointment. IL-1β levels were analyzed using an enzyme-linked immunosorbent assay. Canine movement was measured monthly. Results:  Overall, enhanced IL-1β secretion was observed at the pressure sites of experimental canines compared to control canines (mean, 0.64 ± 0.33 pg/µL vs 0.10 ± 0.11 pg/µL, respectively, P < .001). The accumulative amount of tooth movement was greater for the experimental canine than for the control canine (mean, 2.85 ± 0.17 mm vs 1.77 ± 0.11 mm, respectively, P < .001). Conclusions:  This study demonstrates that, in combination with light orthodontic force, application of vibratory stimuli using an electric toothbrush enhanced the secretion of IL-1β in GCF and accelerated orthodontic tooth movement.

Orthodontic Force–Induced BMAL1 in PDLCs Is a Vital Osteoclastic Activator

2021 ◽  
pp. 002203452110199
Author(s):  
Y. Xie ◽  
Q. Tang ◽  
S. Yu ◽  
W. Zheng ◽  
G. Chen ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Nuclear Factor Κb ◽  
Periodontal Ligament Cells ◽  
Orthodontic Force ◽  
Periodontal Tissues ◽  
Alveolar Bone Remodeling ◽  
Biomechanical Stimuli

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs) sensing biomechanical stimuli and subsequently releasing signals to initiate alveolar bone remodeling. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities are still unclear. This study demonstrates that the core circadian protein aryl hydrocarbon receptor nuclear translocator–like protein 1 (BMAL1) in PDLCs is highly involved in sensing and delivering biomechanical signals. Orthodontic force upregulates BMAL1 expression in periodontal tissues and cultured PDLCs in manners dependent on ERK (extracellular signal–regulated kinase) and AP1 (activator protein 1). Increased BMAL1 expression can enhance secretion of CCL2 (C-C motif chemokine 2) and RANKL (receptor activator of nuclear factor–κB ligand) in PDLCs, which subsequently promotes the recruitment of monocytes that differentiate into osteoclasts. The mechanistic delineation clarifies that AP1 induced by orthodontic force can directly interact with the BMAL1 promoter and activate gene transcription in PDLCs. Localized administration of the ERK phosphorylation inhibitor U0126 or the BMAL1 inhibitor GSK4112 suppressed ERK/AP1/BMAL1 signaling. These treatments dramatically reduced osteoclastic activity in the compression side of a rat orthodontic model, and the OTM rate was almost nonexistent. In summary, our results suggest that force-induced expression of BMAL1 in PDLCs is closely involved in controlling osteoclastic activities during OTM and plays a vital role in alveolar bone remodeling. It could be a useful therapeutic target for accelerating the OTM rate and controlling pathologic bone-remodeling activities.

Human interleukin-1β and interleukin-1 receptor antagonist secretion and velocity of tooth movement

2001 ◽  
Vol 46 (2) ◽  
pp. 185-189 ◽  
Author(s):  
L.R. Iwasaki ◽  
J.E. Haack ◽  
J.C. Nickel ◽  
R.A. Reinhardt ◽  
T.M. Petro
Keyword(s):  
Receptor Antagonist ◽  
Tooth Movement ◽  
Interleukin 1 ◽  
Interleukin 1Β ◽  
Interleukin 1 Receptor Antagonist

Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats

2016 ◽  
Vol 19 (2) ◽  
pp. 83-92 ◽  
Author(s):  
K. Arita ◽  
H. Hotokezaka ◽  
M. Hashimoto ◽  
T. Nakano-Tajima ◽  
T. Kurohama ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Force ◽  
Force Application

scholarly journals Evaluation of levels of Interleukin-1b, intensity of pain and tooth movement during canine retraction using different magnitudes of continuous orthodontic force

2019 ◽  
Vol 8 (7) ◽  
pp. 2373
Author(s):  
PoonamK Jayaprakash ◽  
Rajeshwar Singh ◽  
Ankit Yadav ◽  
Meeta Dawar ◽  
Harpreet Grewal ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Orthodontic Force ◽  
Canine Retraction

FINITE ELEMENT ANALYSIS OF ROOT RESORPTION ASSOCIATED WITH TOOTH MOVEMENT: A SYSTEMATIC REVIEW”

2021 ◽  
pp. 53-59
Author(s):  
Ajit Vikram Parihar ◽  
Shishupal Meena
Keyword(s):  
Systematic Review ◽  
Tooth Movement ◽  
Root Resorption ◽  
Cochrane Collaboration ◽  
Risk Of Bias ◽  
Cochrane Central Register ◽  
3D Fem ◽  
Element Analysis ◽  
Orthodontic Force ◽  
Nite Element

Background: The purpose of this systematic review was to examine the available evidence of root resorption during orthodontic treatment with different force systems using nite element analysis. Methods: The following electronic databases were searched for literature till June 2021 : Pro-Quest Dissertation Abstracts and Thesis database, Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Google Scholar, Embase, US National Library of Medicine, and National Research Register. Root resorption studied under orthodontic forces, which simulated under various technique of nite element method (3D FEM) models were included in the study. The selected studies were assessed for the risk of bias using the Cochrane Collaboration risk of bias tool. The “trafc plot” and “weighted plot” risk of bias distribution were designed using the ROBVIS tool. The authors extracted and analyzed the data. Results: Fourteen studies fullled the inclusion criteria. The risks of biases were high for all studies.Data on quantity and direction of force applied, different type of root morphology and its various surface inuence on root resorption were extracted. The outcomes of the included studies were heterogeneous. Conclusion: Based on the current available literature, for reducing root resorption the excessive force may accelerate root resorption when it exceeds the typical human capillary blood pressure. Root resorption occurs more when extrusion/intrusion and tipping occur than when teeth actually move. A tooth with little or no orthodontic force load hardly shows any root resorption compared to one that has orthodontic force.

scholarly journals Effect of continuous versus intermittent orthodontic forces on root resorption: A microcomputed tomography study

2018 ◽  
Vol 88 (6) ◽  
pp. 733-739 ◽  
Author(s):  
Nurhat Ozkalayci ◽  
Ersan Ilsay Karadeniz ◽  
Selma Elekdag-Turk ◽  
Tamer Turk ◽  
Lam L. Cheng ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Root Resorption ◽  
Experimental Period ◽  
Microcomputed Tomography ◽  
Orthodontic Force ◽  
Rotational Movement ◽  
Force Application ◽  
Orthodontic Forces ◽  
Intermittent Regimen

ABSTRACT Objectives: To compare the extent of root resorption and the amount of tooth movement between continuous orthodontic force and intermittent orthodontic force that was activated in a similar way to a 4-week orthodontic adjustment period. Materials and Methods: Twenty-five patients who required the extraction of upper first premolars were recruited in this study. A buccally directed continuous force of 150 g was applied to the upper first premolar on one side for 15 weeks. A buccally directed intermittent force (28 days on, 7 days off) of the same magnitude was applied to the contralateral first premolar. The teeth were extracted at the end of the experimental period and processed for volumetric evaluations of resorption craters. The degree of tooth movement and rotation were measured on the study models. Results: Continuous force application displayed significantly higher root resorption volume than the intermittent force application (P < .05), particularly on the buccal and lingual surfaces (P < .05) and the middle third of the root (P < .01). There was more tipping and rotational movement in the continuous force group. Conclusions: In a 4-week orthodontic adjustment period, intermittent force significantly reduced the amount of root resorption compared with continuous force. Although there was less degree of tooth movement with intermittent force, unwanted rotational movement was avoided. This is crucial in patients who are predisposed to orthodontically induced inflammatory root resorption, and the use of this intermittent regimen should be considered.

Diurnal variation in tooth movement in response to orthodontic force in rats

1998 ◽  
Vol 114 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Kaoru Igarashi ◽  
Kotaro Miyoshi ◽  
Hisashi Shinoda ◽  
Shuichi Saeki ◽  
Hideo Mitani
Keyword(s):  
Diurnal Variation ◽  
Tooth Movement ◽  
Orthodontic Force

Optimization Spring Coil Design for Orthodontic Tooth Movement

2014 ◽  
Vol 493 ◽  
pp. 327-330
Author(s):  
Moch. Agus Choiron ◽  
Endi Sutikno ◽  
Tri Handoko Wicaksono ◽  
Shigeyuki Haruyama
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Steel Wire ◽  
Orthodontic Tooth Movement ◽  
Maxillary Incisor ◽  
Coil Design ◽  
Hook Length ◽  
Orthodontic Force ◽  
Custom Made ◽  
Spring Coil

Orthodontic tooth movement is achieved by the remodeling of alveolar bone in response to mechanical loading by using spring coil. Spring coil design was made of round stainless steel wire and usually it was custom-made design. In the previous study, the orthodontic force on 30 gram is required to move maxillary incisor during experimental tooth movement in rat. In this study, optimization new design of spring coil is developed to fulfill the requirement of orthodontic force. The design variable of new spring coil design is set on variation of angle aperture (5oα 10o), hook length (10 mml20 mm) and hook diameter (0.012 inchD0.014 inch). From the result, it can be produced the optimum designs which 8.9oof angle aperture; 12 mm of hook length and 0.014 inch of hook diameter for fulfilling the requirement of orthodontic force on 30 gram force.

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