How and Why Was Domesday Made?*

Author(s):  
Stephen Baxter

Abstract This article offers a new interpretation of the Domesday survey, drawing upon a collaborative study of its earliest surviving manuscript, Exeter Cathedral Library MS 3500 (Exon). It identifies five principal stages: first, the survey was launched at Gloucester in midwinter 1085; secondly, fiscal information extracted from geld assessment lists was integrated with manorial detail supplied by landholders to create a survey organised on a geographical plan by hundred; thirdly, this hundredal recension was checked by a second group of commissioners at meetings of shire courts, generating a substantial corpus of contested matter; fourthly, the hundredal recension was restructured into circuit returns which grouped together and summarised the holdings of barons who held directly from the king; fifthly, Domesday Book itself was written directly from these circuit returns. Royal assemblies held at Easter, Whitsun and Lammas functioned as deadlines for the second, third and fourth stages respectively; and a major geld levied at the rate of six shillings to the hide was collected and accounted for during this period. The survey generated a range of different outputs, each intended to serve specific fiscal and political purposes: the hundredal recension was designed to facilitate a reassessment of geld liabilities; the lists of contested matter anticipated a later judicial review; the circuit returns, summaries and Domesday Book were designed to make the administration of the royal demesne and the profits of royal lordship more efficient. The latter also supplied barons with what amounted to confirmation charters of their uncontested holdings, for which they performed homage.

1984 ◽  
Vol 5 ◽  
pp. 241-242
Author(s):  
Uwe Radok

The Symposium on Ice and Climate Modeling was staged by the International Glaciological Society (IGS) with the co-sponsorship of the American Meteorological Society to bring glaciologists into direct contact with modelers of the Earth’s climates during interglacials (such as the present) and glacial episodes. The purpose of mutual familiarization was served by reviews of the hierarchies which now exist for models of atmosphere, ocean, and climate. These reviews emphasized the actual or potential uses of ice data and parameterizations, and both general and specific aspects of coupling and sensitivity testing. The glaciologists in their turn reviewed the problems of exploring different ice forms and simulating their responses to climatic forcing. Interspersed with the didactic presentations important new results were reported. The most significant concerned atmospheric concentrations of carbon dioxide deduced from ice core analyses, which were put into a wider context by a new interpretation of the ocean as a chemical system.The presentations and discussions highlighted a wide range of problems ripe for collaborative study. Topics recommended for priority attention include contemporaneous changes in the properties of ice cores from Greenland and Antarctica, links between weather sequences and the stable isotope contents of polar precipitation, systematic intercomparisons of a wide range of model results, and the construction of intermediate-complexity sea-ice models for use in climate simulations.


1984 ◽  
Vol 5 ◽  
pp. 241-242
Author(s):  
Uwe Radok

The Symposium on Ice and Climate Modeling was staged by the International Glaciological Society (IGS) with the co-sponsorship of the American Meteorological Society to bring glaciologists into direct contact with modelers of the Earth’s climates during interglacials (such as the present) and glacial episodes. The purpose of mutual familiarization was served by reviews of the hierarchies which now exist for models of atmosphere, ocean, and climate. These reviews emphasized the actual or potential uses of ice data and parameterizations, and both general and specific aspects of coupling and sensitivity testing. The glaciologists in their turn reviewed the problems of exploring different ice forms and simulating their responses to climatic forcing. Interspersed with the didactic presentations important new results were reported. The most significant concerned atmospheric concentrations of carbon dioxide deduced from ice core analyses, which were put into a wider context by a new interpretation of the ocean as a chemical system. The presentations and discussions highlighted a wide range of problems ripe for collaborative study. Topics recommended for priority attention include contemporaneous changes in the properties of ice cores from Greenland and Antarctica, links between weather sequences and the stable isotope contents of polar precipitation, systematic intercomparisons of a wide range of model results, and the construction of intermediate-complexity sea-ice models for use in climate simulations.


2001 ◽  
Vol 21 (02) ◽  
pp. 77-81 ◽  
Author(s):  
G. Finazzi

SummaryThrombotic events are a major clinical problem for patients with antiphospholipid antibodies (APA). However, current recommendations for their prevention and treatment are still based on retrospective studies. Data from large scale, prospective clinical trials are required to ultimately identify the optimal management of these patients. To date, at least four randomized studies are underway. The WAPS and PAPRE clinical trials are aimed to establish the correct duration and intensity of oral anticoagulation in APA patients with major arterial or venous thrombosis. The WARSS-APASS is a collaborative study to evaluate the efficacy and safety of aspirin or low-dose oral anticoagulants in preventing the recurrence of ischemic stroke. The recently announced UK Trial compares low-dose aspirin with or without low-intensity anticoagulation for the primary prevention of vascular events in APA-positive patients with SLE or adverse pregnancy history, but still thrombosis-free. It is hoped that the results of these trials will be available soon since clinicians urgently need more powerful data to treat their patients with the APA syndrome.


1987 ◽  
Vol 58 (04) ◽  
pp. 1085-1087 ◽  
Author(s):  
P J Gaffney ◽  
A D Curtis

SummaryAn international collaborative study involving ten laboratories located in eight different countries was undertaken in order to replace the current International Standard (I.S.) for tissue plasminogen activator (t-PA). Two lyophilised candidate preparations of high purity were assessed in comparison with the current I.S. for t-PA using only a clot lysis assay. One preparation (coded 861670) was purified from a cultured melanoma cell supernatant and was about 98% single chain t-PA while the other preparation (coded 861624) was derived from Chinese hamster ovary (CHO) cells following DNA recombinant procedures and was 75% single chain t-PA.Both candidate preparations of t-PA compared in quite a satisfactory manner with the current I.S. from the viewpoint of the biometrics of parallel line bioassays and both preparations were quite stable for long periods at low temperatures and stable from up to 1 month at temperatures of 20° and 38° C. Both fultil the criteria to serve as a satisfactory Znd International Standard for t-PA. The Fibrinolysis Subcommittee of the International Committee for Thrombosis and Haemostasis recommended the melanoma source t-PA (861670) as the next I.S. in order to maintain continuity with the 1st I.S. which was also a melanomatype preparation. The data from the ten laboratories indicated that each ampoule of the new proposed standard contains 850 international units of t-PA activity by the clot lysis assay. It is planned to present the results of this study to the Expert Committee on Biological Standardization of the World Health Organization at its next meeting and to request that the preparation of t-PA, coded 861670, be established as the 2ndlnternational Standard for t-PA.


1990 ◽  
Vol 64 (02) ◽  
pp. 267-269 ◽  
Author(s):  
A B Heath ◽  
P J Gaffney

SummaryAn International Standard for Streptokinase - Streptodomase (62/7) has been used to calibrate high purity clinical batches of SK since 1965. An international collaborative study, involving six laboratories, was undertaken to replace this standard with a high purity standard for SK. Two candidate preparations (88/826 and 88/824) were compared by a clot lysis assay with the current standard (62/7). Potencies of 671 i.u. and 461 i.u. were established for preparations A (88/826) and B (88/824), respectively.Either preparation appeared suitable to serve as a standard for SK. However, each ampoule of preparation A (88/826) contains a more appropriate amount of SK activity for potency testing, and is therefore preferred. Accelerated degradation tests indicate that preparation A (88/826) is very stable.The high purity streptokinase preparation, coded 88/826, has been established by the World Health Organisation as the 2nd International Standard for Streptokinase, with an assigned potency of 700 i.u. per ampoule.


1992 ◽  
Vol 67 (04) ◽  
pp. 424-427 ◽  
Author(s):  
P J Gaffney ◽  
A B Heath ◽  
J W Fenton II

SummarySince 1975 an International Standard for Thrombin of low purity has been used. While this standard was stable and of value for calibrating thrombins of unknown potency the need for a pure a-thrombin standard arose both for accurate calibration and for precise measurement of thrombin inhibitors, notably hirudin. An international collaborative study was undertaken to establish the potency and stability of an ampouled pure a-thrombin preparation. A potency of 97.5 international units (95% confidence limits 86.5-98.5) was established for the new a-thrombin standard (89/ 588) using a clotting-assay procedure. Stability data at various elevated temperatures indicated that the standard could be transported and stored with no significant loss of potency.Ampoules of lyophilised a-thrombin (coded 89/588) have been recommended as an International Standard for a-thrombin with an assigned potency of 100 international units per ampoule by the International Society for Thrombosis and Haemostasis (Thrombin and its Inhibitors Sub-Committee) in Barcelona, Spain in July 1990 while the Expert Committee on Biological Standardisation and Control of the World Health Organisation will consider its status at its next meeting in Geneva in 1991.


1993 ◽  
Vol 69 (05) ◽  
pp. 430-435 ◽  
Author(s):  
Colin Longstaff ◽  
Man-Yu Wong ◽  
Patrick J Gaffney

SummaryAn international collaborative study has been carried out to investigate the reproducibility of hirudin assays in 13 laboratories using four recombinant hirudins and one natural, sulphated product. A simple assay procedure was proposed involving the titration of α-thrombin with inhibitor and measurement of residual activity using a chromogenic substrate. A standard α-thrombin preparation was supplied to ensure that this reagent was of uniform quality throughout the study. The method appeared to present no difficulties and laboratories reported similar potencies for the 5 hirudin samples, in line with expected values. This gave 200–222 Thrombin Inhibitory Units/ampoule (TIU/ampoule) of lyophilised hirudin, with geometric coefficient of variation (gcv) values ranging from 10.15–15.97%. This corresponds to specific activities of approximately 14,300–15,900 TIU/mg protein. This is close to the upper limit of previously reported values of specific activity. We conclude that the precision of this determination compared with the wider range of values in the literature (8,000–16,000 thrombin inhibitory units [TIU]/mg) results from the use of good quality standard α-thrombin by all laboratories. This study has important implications for hirudin standardisation.


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