scholarly journals Association between DNA methylation profiles in leukocytes and serum levels of persistent organic pollutants in Dutch men

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Myrthe W. van den Dungen ◽  
Albertinka J. Murk ◽  
Ellen Kampman ◽  
Wilma T. Steegenga ◽  
Dieuwertje E. Kok
Keyword(s):  
Dna Methylation ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Serum Levels

scholarly journals Maternal plasma concentrations of persistent organic pollutants and placental DNA methylation

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
M. Ouidir ◽  
P. Mendola ◽  
G.M. Buck Louis ◽  
K. Kannan ◽  
C. Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Plasma Concentrations ◽  
Maternal Plasma

DNA Methylation Among Greenlandic Inuit With Varying Levels of Exposures to Specific Persistent Organic Pollutants

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S151-S152 ◽  
Author(s):  
J Rusiecki ◽  
A Baccarelli ◽  
V Bollati ◽  
L Moore ◽  
E Bonefeld-Jorgensen
Keyword(s):  
Dna Methylation ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants

scholarly journals Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Marion Ouidir ◽  
Pauline Mendola ◽  
Germaine M. Buck Louis ◽  
Kurunthachalam Kannan ◽  
Cuilin Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Maternal Plasma

scholarly journals Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status

2021 ◽  
Author(s):  
Anna A. Krönke ◽  
Anne Jurkutat ◽  
Maike Schlingmann ◽  
Tanja Poulain ◽  
Matthias Nüchter ◽  
...  
Keyword(s):  
Weight Gain ◽  
Thyroid Hormone ◽  
Pregnant Women ◽  
Postnatal Development ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Serum Levels ◽  
Maternal Serum ◽  
Hormone Status ◽  
Mother And Child

Abstract Background Potentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed. Methods Working with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child. Results Maternal p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p′-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p′-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p′-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child. Conclusions These results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child. Impact Pregnant women in a German cohort display a substantial accumulation of POPs. Body mass index and age influence maternal serum POP levels. Maternal POP levels show correlations with the child’s length at birth and weight gain, and FT3 levels in the mother and child. Our data provide additional evidence for the potentially harmful influence of POPs. Our data indicate that POPs influence pre- and postnatal development.

Serum levels of persistent organic pollutants and predictors of exposure in Tunisian women

2015 ◽  
Vol 511 ◽  
pp. 530-534 ◽  
Author(s):  
F. Artacho-Cordón ◽  
H. Belhassen ◽  
J.P. Arrebola ◽  
R. Ghali ◽  
D. Amira ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Serum Levels

scholarly journals Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women

2020 ◽  
Vol 17 (2) ◽  
pp. 606
Author(s):  
Eunjung Lee ◽  
April Kinninger ◽  
Giske Ursin ◽  
Chiuchen Tseng ◽  
Susan Hurley ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Mammographic Density ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Multiple Testing ◽  
Serum Levels ◽  
P Value ◽  
Polyfluoroalkyl Substances ◽  
The Impact

There are little epidemiological data on the impact of persistent organic pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong predictor of breast cancer. We assessed MD in 116 non-Hispanic white post-menopausal women for whom serum concentrations of 23 commonly detected chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had been measured. Linear regression analyses adjusting for potential confounders were used to examine the associations between the levels of the chemical compounds, modeled as continuous and dichotomized (above/below median) variables, and square-root-transformed MD. None of the associations were statistically significant after correcting for multiple testing. Prior to correction for multiple testing, all chemicals with un-corrected p-values < 0.05 had regression coefficients less than zero, suggesting inverse associations between increased levels and MD, if any. The smallest p-value was observed for PCB-153 (regression coefficient for above-median vs. below-median levels: −0.87, un-corrected p = 0.008). Neither parity nor body mass index modified the associations. Our results do not support an association between higher MD and serum levels of PBDEs, PCBs, or PFASs commonly detected in postmenopausal women.

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