scholarly journals A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Sun Kwang Kim ◽  
Youngseop Lee ◽  
Hyunjoo Cho ◽  
Sungtae Koo ◽  
Sun Mi Choi ◽  
...  

This study was conducted to compare the effects of low frequency electroacupuncture (EA) and high frequency EA at acupoint ST36 on the production of IgE and Th1/Th2 cytokines in BALB/c mice that had been immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH), as well as to investigate the difference in the immunomodulatory effects exerted by EA stimulations at acupoint ST36 and at a non-acupoint (tail). Female BALB/c mice were divided into seven groups: normal (no treatments), IM (immunization only), ST36-PA (IM + plain acupuncture at ST36), ST36-LEA (IM + low frequency (1 Hz) EA at ST36), ST36-HEA (IM + high frequency (120 Hz) EA at ST36), NA-LEA (IM + low frequency (1 Hz) EA at non-acupoint) and NA-HEA (IM + high frequency (120 Hz) EA at non-acupoint). EA stimulation was performed daily for two weeks, and total IgE, DNP-KLH specific IgE, IL-4 and IFN-γlevels were measured at the end of the experiment. The results of this study showed that the IgE and IL-4 levels were significantly suppressed in the ST36-LEA and ST36-HEA groups, but not in the NA-LEA and NA-HEA groups. However, there was little difference in the immunomodulatory effects observed in the ST36-LEA and ST36-HEA groups. Taken together, these results suggest that EA stimulation-induced immunomodulation is not frequency dependent, but that it is acupoint specific.

1991 ◽  
Vol 81 (4) ◽  
pp. 1101-1114
Author(s):  
Jerry A. Carter ◽  
Noel Barstow ◽  
Paul W. Pomeroy ◽  
Eric P. Chael ◽  
Patrick J. Leahy

Abstract Evidence is presented supporting the view that high-frequency seismic noise decreases with increased depth. Noise amplitudes are higher near the free surface where surface-wave noise, cultural noise, and natural (wind-induced) noise predominate. Data were gathered at a hard-rock site in the northwestern Adirondack lowlands of northern New York. Between 15- and 40-Hz noise levels at this site are more than 10 dB less at 945-m depth than they are at the surface, and from 40 to 100 Hz the difference is more than 20 dB. In addition, time variability of the spectra is shown to be greater at the surface than at either 335- or 945-m depths. Part of the difference between the surface and subsurface noise variability may be related to wind-induced noise. Coherency measurements between orthogonal components of motion show high-frequency seismic noise is more highly organized at the surface than it is at depth. Coherency measurements between the same component of motion at different vertical offsets show a strong low-frequency coherence at least up to 945-m vertical offsets. As the vertical offset decreases, the frequency band of high coherence increases.


2006 ◽  
Vol 27 (4) ◽  
pp. 577-581 ◽  
Author(s):  
Benjamin Munson

Susan Gathercole's Keynote Article (2006) is an impressive summary of the literature on nonword repetition and its relationship to word learning and vocabulary size. When considering research by Mary Beckman, Jan Edwards, and myself, Gathercole speculates that our finding of a stronger relationship between vocabulary measures and repetition accuracy for low-frequency sequences than for high-frequency sequences is due to differences in the range of the two measures. In our work on diphone repetition (e.g., Edwards, Beckman, & Munson, 2004; Munson, Edwards, & Beckman, 2005) we tried to increase the range in our dependent measures by coding errors on a finer grained scale than simple correct/incorrect scoring would allow. Moreover, restriction of range does not appear to be the driving factor in the relationship between vocabulary size and the difference between high- and low-frequency sequence repetition accuracy (what we call the frequency effect) in at least one of our studies (Munson et al., 2005). When the children with the 50 lowest mean accuracy scores for high-frequency sequences were examined, vocabulary size accounted for 10.5% of the variance in the frequency effect beyond what was accounted for by chronological age. When the 50 children with the highest mean accuracy scores for high-frequency sequences were examined (a group in which the range of high-frequency accuracy scores was more compressed, arguably reflecting ceiling effects), an estimate of vocabulary size accounted for only 6.9% of the frequency effect beyond chronological age. The associated β coefficient was significant only at the α<0.08 level. This is the opposite pattern than Gathercole's argument would predict.


2016 ◽  
Vol 33 ◽  
Author(s):  
FILIPP SCHMIDT ◽  
ANDREAS WEBER ◽  
ANKE HABERKAMP

AbstractVisual perception is not instantaneous; the perceptual representation of our environment builds up over time. This can strongly affect our responses to visual stimuli. Here, we study the temporal dynamics of visual processing by analyzing the time course of priming effects induced by the well-known Ebbinghaus illusion. In slower responses, Ebbinghaus primes produce effects in accordance with their perceptual appearance. However, in fast responses, these effects are reversed. We argue that this dissociation originates from the difference between early feedforward-mediated gist of the scene processing and later feedback-mediated more elaborate processing. Indeed, our findings are well explained by the differences between low-frequency representations mediated by the fast magnocellular pathway and high-frequency representations mediated by the slower parvocellular pathway. Our results demonstrate the potentially dramatic effect of response speed on the perception of visual illusions specifically and on our actions in response to objects in our visual environment generally.


Geophysics ◽  
2017 ◽  
Vol 82 (6) ◽  
pp. N51-N60 ◽  
Author(s):  
Sayyid Suhail Ahmad ◽  
R. James Brown ◽  
Alejandro Escalona ◽  
Børge O. Rosland

Our aim was to identify some of the characteristics of low-frequency anomalies. Specifically, we have looked, in 3D broadband data from the North Sea, for any offset dependence in these anomalies and any frequency-related change in normal moveout (NMO) velocity that could influence stacking power over different frequencies. After high-resolution spectral decomposition, two types of low-frequency anomaly have been identified associated with hydrocarbon-bearing reservoirs: (1) at the reservoir top and (2) below the reservoir, with a time delay of approximately 100–200 ms. Both types of anomalies indicate offset dependence. On the near-offset stacks, they are relatively strong, but they tend to be absent on the far-offset stacks. In addition, horizon velocity analysis, which was performed along the horizons picked at the tops of reservoir and nonreservoir intervals, has revealed frequency-dependent NMO velocity. For nonreservoir events, we found no significant difference between the NMO velocities for the low-frequency and high-frequency filtered common-midpoint gathers. However, along the anomalously low-frequency events observed at the tops of, and below, oil-bearing reservoirs, lower velocity is observed for low-frequency and higher velocity for high-frequency filtered gathers. If these properties turn out to be universally typical, increased understanding and inclusion of them could lead to improved workflows and help increase the reliability of low-frequency analysis as a hydrocarbon indicator.


2012 ◽  
pp. 135-144
Author(s):  
M. CHASWAL ◽  
S. DAS ◽  
J. PRASAD ◽  
A. KATYAL ◽  
A. K. MISHRA ◽  
...  

We studied the effect of losartan on baroreflex sensitivity (BRS) and heart rate variability (HRV) of adult Wistar rats during acute and chronic inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME). Chronic L-NAME administration (50 mg/kg per day for 7 days, orally through gavage) increased mean arterial pressure (MAP), heart rate but significantly decreased BRS. In addition, a significant fall of standard deviation of normal RR intervals, total spectral power, high frequency spectral power and a rise of low frequency to high frequency (LF: HF) ratio was seen. Acute L-NAME administration (30 mg/kg, i.v. bolus dose) also raised MAP and impaired HRV but it was associated with augmented BRS for bradycardia reflex. Losartan treatment (10 mg/kg, i.v.) in both acute and chronic L-NAME treated rats, decreased MAP but the difference was not significant. On the other hand, losartan administration normalized depressed BRS for bradycardia reflex and significantly reduced LF to HF ratio in chronic L-NAME treated rats. But this improvement was not observed in acute L-NAME group. These results indicate importance of mechanisms other than renin-angiotensin system in the pressor response of both acute as well as chronic L-NAME. However, autonomic dysregulation especially following chronic L-NAME appears to be partly angiotensin dependent.


2015 ◽  
Vol 93 (11) ◽  
pp. 1391-1396
Author(s):  
Anna Perelomova

The nonlinear effects of sound in electrolyte with a chemical reaction are examined. The dynamic equations that govern non-wave modes in the field of intense sound are derived, and acoustic forces of vortex, entropy, and relaxation modes are determined in the cases of low-frequency sound and high-frequency sound. The difference in the nonlinear effects of sound in electrolyte and in a gas with excited vibrational degrees of molecules, are specified and discussed.


2020 ◽  
Vol 52 (07) ◽  
pp. 500-508
Author(s):  
Hae Woon Jung ◽  
Hwa Young Kim ◽  
Ji Young Kim ◽  
Jung-Eun Cheon ◽  
In-One Kim ◽  
...  

AbstractPatients with craniopharyngioma are susceptible to autonomic dysfunction as a result of hypothalamic damage. We evaluated indices of heart rate variability (HRV) in patients with childhood-onset craniopharyngioma to investigate autonomic function and its relationship with components of the metabolic syndrome (MetS). This cross-sectional, case-only study included 53 patients (10–30 years of age). We measured the standard deviation of all normal R-R intervals (SDNN) and total power indicating overall HRV, the root-mean square of the difference of successive R-R intervals (RMSSD) and high frequency indicating parasympathetic modulation, and low frequency. These indices were compared according to the presence of the MetS. During the mean 10.8 years of follow-up, 25% of patients were diagnosed with the MetS. Patients with the MetS showed significantly lower levels of SDNN (29.0 vs. 40.6 ms), total power (416.1 vs. 1129.6 ms2), RMSSD (20.1 vs. 34.5 ms), high frequency (94.7 vs. 338.5 ms2), and low frequency (94.5 vs. 289.4 ms2) than those without (p <0.05, for all). Individual components of the MetS including insulin resistance, serum triglycerides levels, and systolic blood pressure were inversely associated with SDNN, total power, RMSSD and high frequency. Higher overall variability and parasympathetic modulation were related to decreased odds ratios for having the MetS (OR 0.91, p=0.029 for SDNN; OR 0.91, p=0.032 for total power). In conclusion, autonomic dysfunction, as evidenced by reduced HRV indices, is associated with increased cardiometabolic risk in patients with childhood-onset craniopharyngioma.


Geophysics ◽  
1989 ◽  
Vol 54 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Kenneth W. Winkler ◽  
Hsui‐Lin Liu ◽  
David Linton Johnson

We performed laboratory experiments to evaluate theoretical models of borehole. Stoneley wave propagation in permeable materials. A Berea sandstone and synthetic samples made of cemented glass beads were saturated with silicone oils. We measured both velocity and attenuation over a frequency band from 10 kHz to 90 kHz. Our theoretical modeling incorporated Biot theory and Deresiewicz‐Skalak boundary conditions into a cylindrical geometry and included frequency‐dependent permeability. By varying the viscosity of the saturating pore fluid, we were able to study both low‐frequency and high‐frequency regions of Biot theory, as well as the intermediate transition zone. In both low‐frequency and high‐frequency regions of the theory, we obtained excellent agreement between experimental observations and theoretical predictions. Velocity and attenuation (1/Q) are frequency‐dependent, especially at low frequencies. Also at low frequencies, velocity decreases and attenuation increases with increasing fluid mobility (permeability/viscosity). More complicated behavior is observed at high frequencies. These results support recent observations from the oil field suggesting that Stoneley wave velocity and attenuation may be indicative of formation permeability.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stefano Di Antonio ◽  
Matteo Castaldo ◽  
Marta Ponzano ◽  
Francesca Bovis ◽  
Paola Torelli ◽  
...  

Abstract Objectives This observational study aimed to assess the difference in disability, burden, and sensitization between migraine patients with low-frequency headache attack (1–8 headache days/month), high-frequency headache attack (9–14 headache days/months), and patients with chronic migraine (>14 headache days/months). Methods Migraine patients with or without aura were divided into three groups according to headache frequency (low-frequency episodic migraine; high-frequency episodic migraine; chronic migraine). Questionnaires were used to assess the burden of headache, quality of life, phycological burden, and symptoms related to sensitization (estimated by the Central Sensitization Inventory). Differences among migraine groups were assessed using Chi-Quadro test, ANOVA, or Kruskal–Wallis as appropriate. Results 136 patients were included (68 low-frequency episodic migraine, 45 high-frequency episodic migraine, 23 chronic migraine). Patients with high frequency episodic migraine and chronic migraine differed from patients with low frequency episodic migraine showing a worse burden of headache (p=0.002; p=0.002), worse level of physical (p=0.001; p<0.001) and mental (p=0.002; p=0.001) quality of life, worse level of depression (p=0.008; p=0.003), and increase presence of symptoms related to sensitization (p<0.001; p=0.003). No differences were found in any variables between patients with high-frequency episodic migraine and patients with chronic migraine (p>0.05). Conclusions Patients with high-frequency episodic migraine and chronic migraine could be considered in the same segment of the migraine population, with similar degrees of disability and sensitization related symptoms.


1967 ◽  
Vol 16 (3) ◽  
pp. 317-324 ◽  
Author(s):  
J. C. Sharma

SummaryTaste threshold for phenylthiocarbamide were studied among 242 Tibetans, 125 Spitians and 314 Lahaulis, the three Mongoloid populations of the Indo-Tibetan border. No statistically significant sex differences have been observed in the frequency of tasters and non-tasters in the present study. The frequency of non-tasters among Spitians (12.00%) and Lahaulis 12.73%) is strikingly similar and slightly higher than among Tibetans (10.74%). Statistically the difference in the three populations is non-significant (χ2 = 0.95, df = 2, p>0.05). In spite of the considerable Hindu admixture with a high frequency of non-taster gene, Spitians and Lahaulis have maintained a rather low frequency of non-tasters. This is true of populations all along the cis-Himalayan region, where similar Mongoloid and Hindu admixture has taken place. Besides the main Mongoloid element the proto-Australoid racial strain in the region may also be considered responsible for lowering the frequency of non-tasters.


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