scholarly journals Aqueous Extract of Brazilian Green Propolis: Primary Components, Evaluation of Inflammation and Wound Healing by Using Subcutaneous Implanted Sponges

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Sandra Aparecida Lima de Moura ◽  
Giuseppina Negri ◽  
Antônio Salatino ◽  
Luiza Dias da Cunha Lima ◽  
Luana Pereira Antunes Dourado ◽  
...  
Keyword(s):  
Wound Healing ◽  
Aqueous Extract ◽  
Mass Spectroscopy ◽  
High Performance ◽  
Healing Process ◽  
Treated Group ◽  
Progressive Increase ◽  
Health Condition ◽  
Wound Healing Process ◽  
Morphometric Analyses

Propolis is a chemically complex resinous bee product which has gained worldwide popularity as a means to improve health condition and prevent diseases. The main constituents of an aqueous extract of a sample of green propolis from Southeast Brazil were shown by high performance liquid chromatography/mass spectroscopy/mass spectroscopy to be mono- and di-O-caffeoylquinic acids; phenylpropanoids known as important constituents of alcohol extracts of green propolis, such as artepillin C and drupanin were also detected in low amounts in the aqueous extract. The anti-inflammatory activity of this extract was evaluated by determination of wound healing parameters. Female Swiss mice were implanted subcutaneously with polyesther-polyurethane sponge discs to induce wound healing responses, and administered orally with green propolis (500 mg kg−1). At 4, 7 and 14 days post-implantation, the fibrovascular stroma and deposition of extracellular matrix were evaluated by histopathologic and morphometric analyses. In the propolis-treated group at Days 4 and 7 the inflammatory process in the sponge was reduced in comparison with control. A progressive increase in cell influx and collagen deposition was observed in control and propolis-treated groups during the whole period. However, these effects were attenuated in the propolis-treated group at Days 4 and 7, indicating that key factors of the wound healing process are modulated by propolis constituents.

scholarly journals EFFECT OF MANIHOT ESCULENTA AQUEOUS EXTRACT AND THERAPEUTIC ULTRASOUND IN ACCELERATING THE WOUND HEALING PROCESS IN VITRO

2019 ◽  
Vol 81 (4) ◽  
Author(s):  
Ulfah Anwar ◽  
Siti Pauliena Mohd Bohari
Keyword(s):  
Wound Healing ◽  
Ascorbic Acid ◽  
Aqueous Extract ◽  
Manihot Esculenta ◽  
Wound Closure ◽  
Healing Process ◽  
Therapeutic Ultrasound ◽  
Wound Healing Process ◽  
Time Interval

The aim of this research is to investigate the wound healing process in in vitro by combining the Manihot esculenta aqueous extract and therapeutic ultrasound. Firstly, the optimization seeding densities of HSF cell 1184 in six-well plate, and then followed by the scratch assay experiment. The scratched that made was treated with the remedial treatments (Manihot esculenta aqueous extract only; ascorbic acid+ therapeutic ultrasound; Manihot esculenta aqueous extract+ ascorbic acid; Manihot esculenta aqueous extract+ therapeutic ultrasound and also the combination of these three materials). The rate of wound closure was observed and analysed at a time interval of 0, 2, 4, 6, 8, 10 and 24 h by using image J software. Then, the cells viability were analysed using the MTT assay. The result showed that Manihot esculenta aqueous extract coupled with specific dose therapeutic ultrasound represents a significantly high rate of wound closure at 96.10 % with the cell numbers at 5.44×105 cells/mL when compared to the other combination therapy. The finding of this study revealed that Manihot esculenta aqueous extract 200 µg/mL and the therapeutic ultrasound specific dose (3 MHz, 300 mWatt/cm2, 50% in 5 min) have the potential in accelerating wound healing process of cells in in vitro.

scholarly journals EFEK SERBUK KOPI ROBUSTA (Coffea canephora) TERHADAP PENYEMBUHAN LUKA INSISI PADA KELINCI (Oryctolagus cuniculus)

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Lilian N. Artho ◽  
Jane Wuisan ◽  
J. A. Najoan
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Treated Group ◽  
Coffea Canephora ◽  
Control Group ◽  
Wound Healing Process ◽  
Robusta Coffee ◽  
Coffee Powder ◽  
The Right ◽  
Sterile Gauze

Abstract: Coffee is known as food and drink as well as alternative medicine for various types of wounds. One of the most coffee plants in Indonesia is Robusta coffee (Coffea canephora). This study aimed to determine whether Robusta coffee powder could accelerate the wound healing process. This was an experimental study using four rabbits as subjects. Incisions were made on the rabbit backs, right and left, with a length of 5 cm. Wounds on the left backs, the untreated/control group, were only covered with sterile gauze. Wounds on the right backs, the treated group, were applied with robusta coffee powder and covered with sterile gauze. Robusta coffee powder and gauze were replaced two times a day. Wounds were macroscopically observed for 2 weeks. The results showed that at day 7, the wounds were still equally opened, dry, looked not too deep, and there was a crust on each wound surface. The lengths of the treated wounds were shorter than of the control wounds. At day 14, the edges of the treated wounds looked closer, the crusts were still attached to the wound surfaces and were smaller than of the control wounds. Conclusion: Robusta coffee powder (Coffea canephora) could accelerate the healing process of incised wounds on rabbit skin.Keywords: wound healing, wound incision, robusta coffee powder, coffea canephoraAbstrak: Kopi bukan hanya dikenal sebagai makanan dan minuman saja tetapi bisa juga sebagai obat alternatif dalam menangani berbagai jenis luka. Salah satu jenis tanaman kopi yang paling banyak di Indonesia ialah kopi Robusta (Coffea canephora). Penelitian ini bertujuan untuk menentukan apakah sebuk kopi robusta mempunyai efek untuk mempercepat proses penyembuhan luka. Penelitian ini menggunakan metode eksperimental dengan 4 ekor kelinci sebagai hewan coba. Luka insisi dibuat pada punggung kanan dan kiri kelinci dengan panjang 5 cm. Luka pada punggung kiri merupakan luka kontrol yang tidak diberi perlakuan, hanya ditutupi dengan kasa steril. Luka pada punggung kanan merupakan luka perlakuan dengan diberi serbuk kopi robusta lalu ditutup kasa steril. Serbuk kopi robusta dan kasa diganti dua kali sehari. Pengamatan dilakukan selama 2 minggu dengan membandingkan gambaran makroskopik kedua luka. Hasil penelitian memperlihatkan pada hari ke 7 kedua luka masih sama-sama terbuka, kering, tampak sudah tidak terlalu dalam, dan terdapat kerak yang menempel pada permukaan luka. Ukuran luka perlakuan lebih pendek dari luka kontrol. Hari ke 14 kedua luka sudah mulai menutup, kerak masih menempel pada permukaan luka dan ukuran kerak luka perlakuan lebih kecil dari luka kontrol. Simpulan: Serbuk kopi robusta (Coffea canephora) memiliki efek untuk mempercepat penyembuhan luka insisi pada kulit kelinci.Kata kunci: penyembuhan luka, luka insisi, kopi robusta, coffea canephora

scholarly journals The portrait of neem leaves-based high performance wound healing activity on zebrafish

2021 ◽  
Vol 27 (1) ◽  
pp. 23-27
Author(s):  
Nour Athiroh ◽  
Ari Hayati ◽  
Istirochah Pudjiwati ◽  
Ahmad Taufiq ◽  
Nurul Jadid Mubarakati
Keyword(s):  
Wound Healing ◽  
High Performance ◽  
Healing Process ◽  
Vital Role ◽  
Control Group ◽  
Wound Healing Process ◽  
Physiological Factors ◽  
Neem Leaves ◽  
Significant Difference ◽  
Speed Up

This study was designed to evaluate the role of sliced and dropping models of neem leaves (Azadirachta indica) and environmental factors on zebrafish wound shrinkage. This study employed two treatment models: neem leaf slices and drops model. The treatment in the neem leaf slice model was the control group (fish was injured without neem leaf slices treatment, and G1-G3 of each fish was injured at 0.3 cm + 0.5, 1, and 2 g. Treatment in the neem leaf drop model was control group (fish was injured without neem leaves drops, and G1-G3 of each fish was injured at 0.3 cm + 1, 2, 4 drops. Findings suggest that there is a significant difference between the control group by treating G1, G2, and G3 on the shrinkage of zebrafish wound area both in the neem leaf slice and drop models, but G1 was not significantly different from G2 and G3, as well as G2 and G3 both in the neem leaf slice and drop model. Neem leaves contain nutrients that play a vital role in the formation of collagen and the formation of new capillaries to help speed up the wound healing process. The healing process involves the dynamic interaction of physiological factors.

scholarly journals The Effect of Flaxseed Extract on Skin Elasticity of The Healing Wound In Rabbits

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Abdul Jabbar O ◽  
Kashmoola MA ◽  
Mustafa Al-Ahmad BE ◽  
Mokhtar KI ◽  
Muhammad N ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Clinical Importance ◽  
Treated Group ◽  
Negative Control ◽  
Comparable Efficacy ◽  
Wound Healing Process ◽  
Skin Elasticity ◽  
Tissue Elasticity ◽  
Flaxseed Extract

Introduction: Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid and formation of a fragile epithelial layer. Materials and methods: 27 white New Zealand rabbit included in this study divided into 3 groups; one group of 9 rabbits received Flaxseed gel topically for three time intervals (1, 7, and 14 days); a second group received Fucidin cream as positive control, while a third group has not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system. Results: Throughout the study, skin elasticity was significantly greater in Flaxseed group than in others. Flaxseed decrease elasticity value from (3.46 ± 2.05). Hence, Young's modulus of skin elasticity in flaxseed group was (2.46 ± 1.02) after 14 days (p = 0.003), while no significant differences were evident in both Fucidin group (1.16 ± 0.77) and non-treated group (1.86 ± 1.40) (p = 0.019), accordingly flaxseed extract more reproducible than other groups demonstrating comparable efficacy in skin elasticity and distensibility. Conclusions: This study showed the therapeutic effect of flaxseed on biologic tissue. Elasticity evaluation demonstrated increased density and firmness in the network of collagen fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process.

scholarly journals The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 193
Author(s):  
Nur Izzah Md Fadilah ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Loqman Mohamad Yusof ◽  
Noordin Mohamed Mustapha ◽  
Haslina Ahmad
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Treated Group ◽  
Biologically Active ◽  
Wound Healing Process ◽  
Sprague Dawley ◽  
Liquid Form ◽  
Control Drug ◽  
Hair Follicle Growth

The standard treatment of open wounds via the direct usage of therapeutic agents is not without limitations with respect to healing. Small peptides can create a favorable milieu for accelerating the healing of wounds. This study presents the potential of a novel fatty acid conjugated tetrapeptide (palmitic acid-glycine-aspartic acid-proline-histidine; Palmitoyl-GDPH) in alleviating wound healing. Tetracycline was employed as a standard control drug following its significance in wound healing including biologically active and antimicrobial effects. The peptide in liquid form was applied on to a 4 cm2 full thickness wound surgically induced at the dorsum of Sprague Dawley (SD) rats. The in vivo wound treatment with Palmitoyl-GDPH for eighteen days, histologically demonstrated an almost perfect healing exhibited by increased re-epithelialization, enhanced collagen deposition, and diminished scar formation compared to the controls. In addition, the well-developed epidermal-dermal junction and ultimate stimulation of hair follicle-growth in the Palmitoyl-GDPH treated group indicated the wound to have healed as functionally viable tissues. In general, the much lower hemogram values in the Palmitoyl-GDPH group indicated that the ongoing healing is en route to an earlier recovery. Additionally, the liver, kidney, and pancreas function biomarkers being within normal limits indicated the relatively non-toxic nature of Palmitoyl-GDPH at the used dosage. These results indisputably supported the great potential of this newly synthesized Palmitoyl-GDPH to be used as an effective therapeutic agent for wound healing (this actually means creating a new wound).

Accelerated wound healing process in rat by probiotic Lactobacillus reuteri derived ointment

2019 ◽  
Vol 30 (3) ◽  
Author(s):  
Zohreh Khodaii ◽  
Saman Afrasiabi ◽  
Seied Ali Hashemi ◽  
Abdolreza Ardeshirylajimi ◽  
Mahboobeh Mehrabani Natanzi
Keyword(s):  
Wound Healing ◽  
Lactobacillus Reuteri ◽  
Histopathological Examination ◽  
Healing Process ◽  
Treated Group ◽  
Probiotic Bacterium ◽  
Control Group ◽  
Wound Healing Process ◽  
Positive Effects ◽  
Antioxidant Agents

Abstract Background Antioxidant agents have positive effects on wound healing process and on the other hand probiotics also have great antioxidation or oxidation-resistance properties. Methods In this study, we investigated the effects of Lactobacillus reuteri derived ointment as a probiotic bacterium on the wound healing process using a full-thickness rat skin model. The wound diameter and contraction percent measurement, histopathological examination, and myeloperoxidase (MPO) enzyme activity evaluation were carried out during the period of study. Results Amount of deposit collagen was significantly increased; epithelization speed and epidermis production were also observed in the ointment-treated group, while the inflammation rate was also significantly lower than the control group. In addition, a significant reduction in the activity of enzyme MPO was also detected in the ointment-treated group. Conclusions According to the results, probiotic ointment effectively accelerates the wound healing process and it can be used as a promising drug for wound dressing application.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

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