scholarly journals Could there Be a Synthesis between Western and Oriental Medicine, and with Sasang Constitutional Medicine in Particular?

2009 ◽  
Vol 6 (s1) ◽  
pp. 5-10 ◽  
Author(s):  
Denis Noble
Keyword(s):  
Systems Biology ◽  
Theory And Practice ◽  
Patient Specific ◽  
Oriental Medicine ◽  
Mathematical Methods ◽  
Biological Organization ◽  
Central Concept ◽  
Specific Analysis ◽  
Sasang Constitutional Medicine ◽  
Constitutional Medicine

Attitudes towards oriental medicine are changing for two major reasons. The first is that many patients, even in the West, are choosing to use its practitioners and methods. The second is that the rise of Systems Biology may offer a better basis for dialogue, and even for synthesis, between the oriental and Western traditions. However, a lot of work is needed to clear the way for such dialogue and synthesis. Much of this work should be devoted to clarifying the meanings of the terms used, and the framework of theory and practice within which oriental methods operate. But it is also necessary for Systems Biology itself to mature as a discipline, particularly at the higher levels of biological organization since it is at these levels that oriental medicine derives its ideas and practice. Higher level Systems Biology could be a basis for interpretation of the Korean version of oriental medicine: Sasang constitutional medicine since it seeks patient specific analysis and treatment, and the mathematical methods of systems biology could be used to analyze the central concept of balance in Sasang.

scholarly journals Quantitative Sasang Constitution Diagnosis Method for Distinguishing between Tae-eumin and Soeumin Types Based on Elasticity Measurements of the Skin of the Human Hand

2009 ◽  
Vol 6 (s1) ◽  
pp. 93-98 ◽  
Author(s):  
Han Wook Song ◽  
SungJun Lee ◽  
Yon Kyu Park ◽  
Sam Yong Woo
Keyword(s):  
Human Hand ◽  
Oriental Medicine ◽  
Compression Method ◽  
Repeatability Error ◽  
Sasang Constitution ◽  
Diagnosis Method ◽  
Sasang Constitutional Medicine ◽  
Constitutional Medicine ◽  
Measurement Repeatability ◽  
Elasticity Measurements

The usefulness of constitutional diagnoses based on skin measurements has been established in oriental medicine. However, it is very difficult to standardize traditional diagnosis methods. According to Sasang constitutional medicine, humans can be distinguished based on properties of the skin, including its texture, roughness, hardness and elasticity. The elasticity of the skin was previously used to distinguish between people with Tae-eumin (TE) and Soeumin (SE) constitutions. The present study designed a system that uses a compression method to measure the elasticity of hand skin and evaluated its measurement repeatability. The proposed system was used to compare the skin elasticity between SE and TE subjects, which produced a measurement repeatability error of <3%. The proposed system is suitable for use as a quantitative constitution diagnosis method for distinguishing between TE and SE subjects with an acceptable level of uncertainty.

scholarly journals Strategic Approach to the Globalization of Sasang Constitutional Medicine

2011 ◽  
Vol 2011 ◽  
pp. 1-2
Author(s):  
Myeong Soo Lee
Keyword(s):  
Traditional Medicine ◽  
Panel Discussion ◽  
The Other ◽  
Oriental Medicine ◽  
Discussion Session ◽  
Strategic Approach ◽  
Korean Traditional Medicine ◽  
Sasang Constitutional Medicine ◽  
Constitutional Medicine ◽  
Further Development

The workshop on “Strategic Approach to the Globalization of Sasang Constitutional Medicine (SCM)” was held in the Korea Institute of Oriental Medicine (KIOM) on September 18, 2009. This workshop was designed to discuss and brainstorm the strategic approach to the globalization of SCM, one of the unique systems in Korean Traditional Medicine, with three topics and an extensive panel discussion. Professor Edwin Cooper, Editor-in-Chief ofeCAM, gave a commemorative lecture for publication of the second supplement ofeCAMentitled “Sasang Constitutional Medicine as a Holistic Tailored Medicine”. The other two presenters suggested some practical methods for globalization of SCM on the basis of their experiences. After the three main presentations, there was a panel discussion session for further development of workshop topics, extended by five other external experts. They discussed the benefits, limitations and essentials for globalization of Korean Traditional Medicine, specifically SCM, from bench to bedside.

scholarly journals Korean Oriental Medicine in Stroke Care

2005 ◽  
Vol 10 (2) ◽  
pp. 105-117 ◽  
Author(s):  
Yong-Suk Kim ◽  
Jun Wang ◽  
Douglas Mann ◽  
Susan Gaylord ◽  
Hye-Jung Lee ◽  
...  
Keyword(s):  
Health Care ◽  
Stroke Care ◽  
Future Research ◽  
Primary Health Care System ◽  
Oriental Medicine ◽  
Primary Health ◽  
Preliminary Study ◽  
Sasang Constitutional Medicine ◽  
Constitutional Medicine ◽  
Korean Hand Acupuncture

Korean Oriental medicine (KOM), known as Hanbang in Korea, is the primary health care system for more than 20% of the population in Korea. Often integrated with allopathic Western medicine, it has been used and studied extensively in Korea for a variety of conditions, including stroke and Parkinson’s disease. Although KOM shares its origins with traditional Chinese medicine, its unique cultural contributions include a number of innovations in diagnosis and technique, such as Sasang constitutional medicine, Saam acupuncture, herbal acupuncture, and Korean hand acupuncture. This article reviews the development and use of KOM in Korea, focusing on a major component, Sasang constitutional medicine. It describes a preliminary study of effectiveness of Sasang constitutional medicine in the treatment of stroke and discusses the directions of future research in KOM.

scholarly journals Systems biology informed neural networks (SBINN) predict response and novel combinations for PD-1 checkpoint blockade

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Michelle Przedborski ◽  
Munisha Smalley ◽  
Saravanan Thiyagarajan ◽  
Aaron Goldman ◽  
Mohammad Kohandel
Keyword(s):  
Neural Networks ◽  
Systems Biology ◽  
Clinical Data ◽  
Treatment Protocol ◽  
Response Prediction ◽  
Clinical Findings ◽  
Patient Specific ◽  
Patient Response ◽  
Triple Combination Therapy ◽  
Parameter Values

AbstractAnti-PD-1 immunotherapy has recently shown tremendous success for the treatment of several aggressive cancers. However, variability and unpredictability in treatment outcome have been observed, and are thought to be driven by patient-specific biology and interactions of the patient’s immune system with the tumor. Here we develop an integrative systems biology and machine learning approach, built around clinical data, to predict patient response to anti-PD-1 immunotherapy and to improve the response rate. Using this approach, we determine biomarkers of patient response and identify potential mechanisms of drug resistance. We develop systems biology informed neural networks (SBINN) to calculate patient-specific kinetic parameter values and to predict clinical outcome. We show how transfer learning can be leveraged with simulated clinical data to significantly improve the response prediction accuracy of the SBINN. Further, we identify novel drug combinations and optimize the treatment protocol for triple combination therapy consisting of IL-6 inhibition, recombinant IL-12, and anti-PD-1 immunotherapy in order to maximize patient response. We also find unexpected differences in protein expression levels between response phenotypes which complement recent clinical findings. Our approach has the potential to aid in the development of targeted experiments for patient drug screening as well as identify novel therapeutic targets.

scholarly journals Formalization of Methods in Criminalistics

2019 ◽  
Vol 75 (4) ◽  
pp. 86-90
Author(s):  
L. P. Grynko
Keyword(s):  
Forensic Science ◽  
Theory And Practice ◽  
Independent Research ◽  
Theoretical Level ◽  
Mathematical Methods ◽  
Material Models ◽  
Theoretical Methods ◽  
Judicial Practice ◽  
Sign System ◽  
Practical Recommendations

Scientific works on formalization of methods in criminalistics have been analyzed in the article. Despite the importance and relevance of these issues, it has been established that there is a number of unresolved issues in the theory of forensic science, as well as in investigative and judicial practice regarding the possibilities of formalizing methods and their implementation, which require separate independent research and in-depth reflection. Accordingly, the purpose of this article is to clarify the methods used to detect and investigate crimes and the possibilities of their formalization in criminalistics. Formalization methods in criminalistics have been considered. It has been found out that the most successful is their division into formalization of theoretical methods and formalization of practical methods. Methods of theoretical level have been researched. It has been emphasized that the use of mathematical methods contributes to the development of the most accurate practical recommendations, which allow to approach many issues of the theory and practice of forensic science from new positions. The author has considered the modeling method and has argued that it creates the preconditions for the use of formalization, since acting as prototypes, plans, hypothetical constructions of all kinds, this process is presented to investigators as a complex of interrelated transformations in the form of description. The development and use of forensic material models in the management of an investigative situation allows investigators to use, by analogy, forensic algorithms and investigative programs. Thus, the formalization is carried out in the form of the transition of content into a sign system. It is designed to address the tasks faced by investigators and directly related to the investigative situation existing at the time of the investigation. It has been found out that the formalization of forensic knowledge methods allows the use of such knowledge in the process of solving problems and making decisions by means of signs and symbols, which may increase the capacity of investigators to solve problems at all stages of crime investigation in different conditions of uncertainty.

Sign in / Sign up

Export Citation Format

Share Document