scholarly journals Evaluation of Influence of Acupuncture and Electro-Acupuncture for Blood Perfusion of Stomach by Laser Doppler Blood Perfusion Imaging

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Zhang Dong ◽  
Li Shun-Yue ◽  
Wang Shu-You ◽  
Ma Hui-Min
Keyword(s):  
Perfusion Imaging ◽  
Imaging Technique ◽  
Flow Distribution ◽  
Blood Perfusion ◽  
Laser Doppler ◽  
Control Group ◽  
Blood Flow Distribution ◽  
Perfusion Image ◽  
Maximum Increase ◽  
Before And After

The objective of this study is to observe effects of acupuncture and electro-acupuncture (EA) on blood perfusion in the stomach, and probe into the application of laser Doppler blood perfusion imaging technique in the study of the effect of acupuncture and moxibustion on the entrails. In the acupuncture group of 20 rats, acupuncture was given at “Zusanli” (ST 36) and in EA group of 18 rats, EA was applied at “Zusanli” (ST 36), with 18 rats without acupuncture used as control group. Changes of blood perfusion and microcirculation distribution in the stomach were investigated with laser Doppler blood perfusion imager (LDPI). The laser Doppler blood perfusion image could clearly display changes of blood flow distribution in the stomach before and after acupuncture. After acupuncture or EA was given at “Zusanli” (ST 36), the blood perfusion in the stomach increased significantly, the blood perfusion in the blood vessels and microcirculation of other parts significantly increased, and the maximum increase of the blood perfusion was found at 10 min after acupuncture or EA, with increases of 0.50 _ 0.11 (PU) and 0.66 _ 0.16 (PU), respectively, and the blood perfusion still kept at a higher degree within 10 min after ceasing of the acupuncture or EA. While the blood perfusion in the stomach in the rat of the control group tended to gradual decrease. It has been concluded that both acupuncture and EA can increase blood perfusion in the stomach, the EA having stronger action, and LDPI can display the regulative action of acupuncture on the blood vessel of the stomach by using an image.

Intravenous infusion of nitroglycerin: effects upon cardiovascular dynamics and regional blood flow distribution in conscious dogs

1982 ◽  
Vol 60 (12) ◽  
pp. 1436-1443 ◽  
Author(s):  
Louis Dumont ◽  
Claudette Lamoureux ◽  
Jacques Lelorier ◽  
Paul Stanley ◽  
Claude Chartrand
Keyword(s):  
Blood Flow ◽  
Regional Blood Flow ◽  
Flow Distribution ◽  
Blood Perfusion ◽  
Left Ventricular ◽  
Conscious Dogs ◽  
Blood Flow Distribution ◽  
Hemodynamic Changes ◽  
Before And After ◽  
Local Reflex

We have studied both central and peripheral hemodynamic changes induced by infusion of nitroglycerin (55 μg/kg per minute) over a 15-min period in conscious dogs to clarify its mechanism of action. Dogs were prepared with an electromagnetic flow probe positioned at the root of the aorta, and microspheres (9 μm) were used to measure regional blood flow distribution before and after 15 min of infusion. Controlled hypotension (−15 to −20 mmHg (1 mmHg = 133.322 Pa)) was maintained throughout the infusion period and this hypotensive state was associated with a significant decrease in stroke volume (−30%), cardiac index (−20%), and left ventricular work (−43%). Regional blood flow studies showed that at the 15th min of infusion, nitroglycerin induced significant decrease in blood flow to all components of the myocardium (range −12 to −20%) while their vascular resistances were not affected significantly. Blood perfusion to liver (hepatic artery), spleen, and intestine was also modified significantly (−22, −18, and −16%, respectively) while their vascular resistances remained close to control values. By the time measurements were made, blood flow and vascular resistance of cerebral and renal tissues remained normal. For each organ studied, blood perfusion was uniform. These results indicate that nitroglycerin elicits both central and peripheral hemodynamic changes and that local reflex adjustments modify the vasodilator effect of the drug in most vascular beds that we have studied.

Abstract 722: Treatment of Acute and Chronic Limb Ischemia with Intermedin (IMD) in Mouse Models

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Luyu Yao ◽  
Honglin Dong ◽  
Allen Gu ◽  
Xin Gu ◽  
Kai Yao ◽  
...  
Keyword(s):  
Femoral Artery ◽  
Blood Perfusion ◽  
Limb Ischemia ◽  
Control Group ◽  
Silk Suture ◽  
Hindlimb Ischemia ◽  
Occlusion Model ◽  
Before And After ◽  
Artery Disease ◽  
The One

Objectives: This experiment proposes a novel mouse model to simulate long-term chronic ischemia caused by peripheral artery disease (PAD) using a partial ligation method to narrow down the femoral artery lumen in C57Bl/6 mice. This model will be compared to the typical occlusion model while testing Intermedin (IMD) as a possible treatment for ischemia. Methods: Partial hindlimb ligation technique: we use a strand of 11-0 nylon sutures to pierce the middle of the artery and suture half of the artery shut at both the proximal and distal end of the femoral artery. The typical occlusion model: we use a 7-0 silk suture to completely ligate the distal and proximal femoral artery. Hindlimb blood flow was monitored daily by Laser Doppler perfusion monitor before and after the surgery. IMD was administered at 150 μg/kg, ip, immediately following ligation and twice daily afterwards for up to one week, while in the control group saline was injected instead of IMD. Gastrocnemius muscle samples were collected at day 3 and day 7 for histology and molecular biology study. Results: Ischemic/non-ischemic leg blood perfusion ratio in the partial ligation model is significantly higher than in the typical model. It is also significantly increased in IMD-treated groups in both models. Compared to the tissue in complete ligation models, it is apparent that partial ligation model tissue is less severely affected upon initial ligation but maintains ischemia over the one week testing period as would be expected. Compared to the untreated ischemia groups in acute and chronic hindlimb ischemia models, IMD-treated animals had less severe ischemic injuries. Conclusion: Our study indicates that our chronic hindlimb ischemia model was successful with expected less ischemia status than complete occlusion. The partial occlusion model presented here more closely mimics human PAD, where atherosclerotic plaque builds up slowly, resulting in a lower pressure difference between the proximal and distal artery preventing adequate shunting of the blood into collateral circulation. Moreover, our study suggests that IMD has promise as a therapeutic treatment in acute and chronic hindlimb ischemia models to prevent necrosis in muscle tissue following ischemic events.

Hemodilution during Venous Gas Embolization Improves Gas Exchange, without Altering V̇A/Q̇ or Pulmonary Blood Flow Distributions 

1999 ◽  
Vol 91 (6) ◽  
pp. 1861-1861 ◽  
Author(s):  
Steven Deem ◽  
Steven McKinney ◽  
Nayak L. Polissar ◽  
Richard G. Hedges ◽  
Erik R. Swenson
Keyword(s):  
Blood Flow ◽  
Gas Exchange ◽  
Lung Injury ◽  
Partial Pressure ◽  
Pulmonary Blood Flow ◽  
Flow Distribution ◽  
Arterial Oxygen ◽  
Control Group ◽  
Blood Flow Distribution ◽  
Over Time

Background Isovolemic anemia results in improved gas exchange in rabbits with normal lungs but in relatively poorer gas exchange in rabbits with whole-lung atelectasis. In the current study, the authors characterized the effects of hemodilution on gas exchange in a distinct model of diffuse lung injury: venous gas embolization. Methods Twelve anesthetized rabbits were mechanically ventilated at a fixed rate and volume. Gas embolization was induced by continuous infusion of nitrogen via an internal jugular venous catheter. Serial hemodilution was performed in six rabbits by simultaneous withdrawal of blood and infusion of an equal volume of 6% hetastarch; six rabbits were followed as controls over time. Measurements included hemodynamic parameters and blood gases, ventilation-perfusion (V(A)/Q) distribution (multiple inert gas elimination technique), pulmonary blood flow distribution (fluorescent microspheres), and expired nitric oxide (NO; chemoluminescence). Results Venous gas embolization resulted in a decrease in partial pressure of arterial oxygen (PaO2) and an increase in partial pressure of arterial carbon dioxide (PaCO2), with markedly abnormal overall V(A)/Q distribution and a predominance of high V(A)/Q areas. Pulmonary blood flow distribution was markedly left-skewed, with low-flow areas predominating. Hematocrit decreased from 30+/-1% to 11+/-1% (mean +/- SE) with hemodilution. The alveolar-arterial PO2 (A-aPO2) difference decreased from 375+/-61 mmHg at 30% hematocrit to 218+/-12.8 mmHg at 15% hematocrit, but increased again (301+/-33 mmHg) at 11% hematocrit. In contrast, the A-aPO2 difference increased over time in the control group (P < 0.05 between groups over time). Changes in PaO2 in both groups could be explained in large part by variations in intrapulmonary shunt and mixed venous oxygen saturation (SvO2); however, the improvement in gas exchange with hemodilution was not fully explained by significant changes in V(A)/Q or pulmonary blood flow distributions, as quantitated by the coefficient of variation (CV), fractal dimension, and spatial correlation of blood flow. Expired NO increased with with gas embolization but did not change significantly with time or hemodilution. Conclusions Isovolemic hemodilution results in improved oxygen exchange in rabbits with lung injury induced by gas embolization. The mechanism for this improvement is not clear.

Laser Doppler Perfusion Imaging for Assessment of Skin Blood Perfusion After Acupuncture

2008 ◽  
Vol 20 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Wei-bo Zhang ◽  
Ling-ling Wang ◽  
Tao Huang ◽  
Yu-ying Tian ◽  
Yi-hui Xu ◽  
...  
Keyword(s):  
Perfusion Imaging ◽  
Blood Perfusion ◽  
Laser Doppler ◽  
Laser Doppler Perfusion Imaging ◽  
Skin Blood Perfusion

scholarly journals Blood flow distribution in submerged and surface-swimming ducks

1992 ◽  
Vol 166 (1) ◽  
pp. 285-296
Author(s):  
R. Stephenson ◽  
D. R. Jones
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Water Surface ◽  
Imaging Technique ◽  
Flow Distribution ◽  
Tissue Blood Flow ◽  
Blood Flow Distribution ◽  
Radiological Imaging ◽  
Aythya Americana

Observations that the response of the avian heart rate to submergence varies under different circumstances have led to speculation about variability of blood flow distribution during voluntary dives. We used a radiological imaging technique to examine the patterns of circulating blood flow in captive redhead ducks (Aythya americana) during rest, swimming, escape dives, forced dives and trapped escape dives and have shown that blood flow distribution in escape dives was the same as that in ducks swimming at the water surface. The response during trapped escape dives, however, was highly variable. Blood pressure was unchanged from the resting value during all activities. Predictions made about blood flow distribution during unrestrained dives on the basis of heart rate and other indirect data were confirmed in this study. However, the trapped escape dive responses indicated that heart rate alone is not always a reliable indicator of tissue blood flow in exercising ducks.

scholarly journals Changes in EEG Alpha Activity during Attention Control in Patients: Association with Sleep Disorders

2021 ◽  
Vol 11 (7) ◽  
pp. 601
Author(s):  
Anastasiya Runnova ◽  
Anton Selskii ◽  
Anton Kiselev ◽  
Rail Shamionov ◽  
Ruzanna Parsamyan ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Alpha Rhythm ◽  
Quantitative Eeg ◽  
Alpha Activity ◽  
Primary Insomnia ◽  
Control Group ◽  
Frequency Range ◽  
Maximum Increase ◽  
Before And After ◽  
Eeg Alpha Activity

We aimed to assess which quantitative EEG changes during daytime testing in patients with sleep disorder (primary insomnia and excessive daytime sleepiness groups). All experimental study participants were subjected to a long-term test for maintaining attention to sound stimuli, and their EEGs were recorded and then processed, using wavelet analysis, in order to estimate the power and frequency structure of alpha activity. In healthy subjects, the maximum increase in the alpha rhythm occurred near 9 Hz. Patients with primary insomnia were characterized by an increase in the amplitude of the alpha rhythm near 11 Hz. For subjects with sleep disorders, an increase in the amplitude of the alpha rhythm was observed in the entire frequency range (7.5–12.5 Hz), with a maximum increase at 9–10 Hz. Significant differences (p≤0.001) for changes in the alpha rhythm dynamics in the course of performing the attention test were observed in the frequency range of 7.5–10.5 Hz between the control group and patients with sleep disorders. The ratios of the alpha rhythm power values for passive stages with closed eyes before and after active stage were significantly different among the groups of healthy sleep volunteers, patients with primary insomnia, and patients with impaired sleep hygiene within the range of 9.5 to 12.5 Hz. The results of the current study supported the notion of a 24-h hyperarousal in primary insomnia.

Two-Dimensional Laser Doppler Perfusion Imaging and Microcirculatory Function in Patients with Venous Skin Damage

1995 ◽  
Vol 10 (1) ◽  
pp. 32-36 ◽  
Author(s):  
T. R. Cheatle ◽  
C. Quashie ◽  
B. Villemur ◽  
P. Carpentier
Keyword(s):  
Perfusion Imaging ◽  
Venous Insufficiency ◽  
Venous Hypertension ◽  
Laser Doppler ◽  
Control Group ◽  
Two Dimensional ◽  
Skin Damage ◽  
Disease Group ◽  
Laser Doppler Perfusion Imaging ◽  
Microcirculatory Function

Objective: To assess the use of two-dimensional laser Doppler perfusion imaging in the quantification of venous skin damage. Design: Comparison of disease group with control group. Setting: Department of Medicine, Hôpital du Nord, Grenoble, France. Subjects: Six patients (nine limbs) with lipodermatosclerosis (LDS) due to duplex-proven venous insufficiency and six controls subjects (11 limbs). Interventions: Perfusion images were collected at rest, after venous hypertension and after skin heating. Main outcome measures: Mean skin perfusion (mV). Results: An increased basal flux at rest was found in lipsclerotic skin (1.6 V) compared with controls (0.94, V, 95% CI = 0.16–1.48). An impairment of hyperaemic responsiveness to heat was also shown (factor of increase = 1.87 (LDS) compared with 3.28 (controls); 95% CI = 0.85–2.44).

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