scholarly journals Soybeans Ameliolate Diabetic Nephropathy in Rats

2010 ◽  
Vol 7 (4) ◽  
pp. 433-440 ◽  
Author(s):  
Young Eun Choi ◽  
Soo Kyung Ahn ◽  
Won Taek Lee ◽  
Jong Eun Lee ◽  
Seung Hwa Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Diabetic Rat ◽  
Diabetic Patients ◽  
Chow Diet ◽  
Protein Excretion ◽  
Tubulointerstitial Lesions ◽  
Soybean Diet

Diabetic nephropathy is one of the most frequent and serious complications of diabetes mellitus. Soybeans have been shown to reduce urinary albumin excretion and total cholesterol in non-diabetic patients with nephrotic syndrome. However, reports focusing specifically on diabetic nephropathy are scarce and the available results are inconsistent. It was reported that soybean consumption reduced urinary protein excretion in type 1 diabetic patients with diabetic nephropathy, whereas it was found to elicit an increase in urinary protein excretion when soybeans were consumed by type 2 diabetic patients. This study aims to investigate the effects of soybean in diabetic nephropathy, particularly the effects of consuming soybeans on the histopathology of diabetic nephropathy, using aquaporin (AQP) and osteopontin (OPN) expression as diagnostic markers. Male Sprague-Dawley rats were assigned to one of three groups: control, diabetic with red chow diet and diabetic with soybean diet. For histological examination, the expression of OPN and AQP, renal function and hemoglobin A1c were evaluated at the end of the study. Improvements in glomerular and tubulointerstitial lesions were demonstrated in the diabetic rat group given a soybean diet. OPN and AQP expression were suppressed in the kidney specimens of diabetic rats with the soybean diet. In conclusion, soybeans may prevent the weight loss and morphological disruption of the kidney associated with diabetes mellitus. Soybeans also may improve glycemic control. It seems likely that long-term control of blood glucose levels using a soybean diet could prevent the progression of diabetes mellitus, and therefore, nephropathy could be prevented.

Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy?

2007 ◽  
Vol 13 (4) ◽  
pp. 391-397 ◽  
Author(s):  
N. Bavbek ◽  
A. Kargili ◽  
O. Kaftan ◽  
F. Karakurt ◽  
A. Kosar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Mean Platelet Volume ◽  
Plasma Levels ◽  
Platelet Reactivity ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Soluble Adhesion Molecules ◽  
Protein Excretion

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls ( P = .001 and P = .007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria ( P = .002 and P = .004, respectively). Protein excretion was lower in patients with low mean platelet volume values ( P = .004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results.

Diurnal Variation in Urinary Protein Excretion in Diabetic Nephropathy

1991 ◽  
Vol 6 (4) ◽  
pp. 238-243 ◽  
Author(s):  
C. D. A. Stehouwer ◽  
H. R. A. Fischer ◽  
W. H. L. Hackeng ◽  
G. J. H. den Ottolander ◽  
A. J. M. Donker
Keyword(s):  
Diabetic Nephropathy ◽  
Diurnal Variation ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Protein Excretion

Effects of pentoxifylline on the urinary protein excretion profile of type 2 diabetic patients with microproteinuria – A double-blind, placebo-controlled randomized trial

2006 ◽  
Vol 66 (07) ◽  
pp. 3-10 ◽  
Author(s):  
M. Rodríguez-Morán ◽  
G. González-González ◽  
M.V. Bermúdez-Barba ◽  
C.E. Medina de la Garza ◽  
H.E. Tamez-Pérez ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Protein Excretion ◽  
Type 2 Diabetic

scholarly journals The Diabetic Nephropathy and the Development of Hypertension in Rats

2001 ◽  
Vol 2 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Adriana Zuccollo ◽  
Monica Navarro ◽  
Orlando Catanzaro
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
The Other ◽  
Urinary Kallikrein ◽  
Hypertensive Rats ◽  
The Third ◽  
Protein Excretion ◽  
High Prevalence

The present study was designed to examine the development of hypertension in diabetic rats treated with streptozotocin (STZ, 1mg/g bw). The rats were studied at 3, 6, 9, 12 and 15 weeks. From the third week the rats were divided in diabetic rats according their glycemias and controls, along 15 weeks. After the third week a group, of rats showed increased urinary protein excretion (93, 134, 155 and 191%) compared to controls. In this group of rats the urinary kallikrein excretion was lower than control and the systolic blood pressure became significantly elevated between 3 and 6 weeks and persisted up to 15 weeks. On the other hand a group of diabetic rats were normotensive with urinary protein excretion similar to controls and urinary kallikrein lower compared to control but significantly higher compared diabetic hypertensive rats. These data suggest that the association of progressive diabetic nephropathy with abnormal endothelium-dependent vasodilation may produce a high prevalence of hypertensive diabetes.

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