scholarly journals Interaction of Aqueous Extract ofPleurotus pulmonarius(Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice

2008 ◽  
Vol 5 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Sachin L. Badole ◽  
Naimesh M. Patel ◽  
Prasad A. Thakurdesai ◽  
Subhash L. Bodhankar
Keyword(s):  
Glucose Level ◽  
Aqueous Extract ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Pleurotus Pulmonarius ◽  
Body Weights ◽  
Glass Tubes

Mushrooms are low calorie food with very little fat and are highly suitable for obese persons. With no starch and very low sugars, they are the ‘delight of the diabetics’. Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs. The aim of the present study was to evaluate the effects of aqueous extract ofPleurotus pulmonarius(Lentinaceae) (called as PP-aqu) and its interaction with glyburide in alloxan induced diabetic mice. The diabetic mice treated were with PP-aqu (500 mg/kg, p.o.) alone or combination with glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were collected by orbital sinus puncture using heparinized capillary glass tubes and were analyzed for serum glucose on 0, 7th, 14th, 21st and 28th days. Body weights and mortality were noted during the study period. In oral glucose tolerance test (OGTT), glucose (2.5 g/kg, p.o.) was administered with either vehicle, PP-aqu alone or in combination with glyburide and serum glucose level analyzed at 0, 30, 60 and 120 min after drug administration. Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P< 0.001) decreased serum glucose level in diabetic mice. In OGTT, glyburide or PP-aqu treatment alone or their combination produced significant (P< 0.001) increase in glucose threshold. Thus we suggest thatP. pulmonariusshowed potent and synergistic antihyperglycemic effect in combination with glyburide.

scholarly journals Effect of Leaf Aqueous Extract of Manilkara hexandra on Digestive and Glucose Metabolic Enzymes, and Serum Glucose Level in Labeo rohita Fingerlings

2021 ◽  
Author(s):  
Sumana Dutta ◽  
Debnarayan Chowdhury ◽  
Ria Das ◽  
Jayashri Das ◽  
Poulomi Ghosh ◽  
...  
Keyword(s):  
Glucose Level ◽  
Aqueous Extract ◽  
Labeo Rohita ◽  
Metabolic Enzymes ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Control Group ◽  
Phosphatase Activities ◽  
Group Iii ◽  
Leaf Aqueous Extract

AbstractManilkara hexandra (Roxb.) Dubard (common name Khirni, family: Sapotaceae) is an evergreen traditionally used medicinal plant. The present study aimed to see the effects of leaf aqueous extract of M. hexandra (LAEMH) on digestive and glucose metabolic enzyme action and serum glucose level in rohu, Labeo rohita, fingerlings. Experimental fish were fed a basal diet (Group I), and diets supplemented with LAEMH at 300 mg (Group II) and 600 mg (Group III) kg−1 body weight. A significant reduction in serum glucose was noticed in the treated groups when compared with the control group. The reduced amylase activity was noticed in the treated fingerlings in a dose-dependent manner. However, lipase and protease activities didn’t differ significantly among the experimental groups. Reduced serum glucose level might be correlated with the decline in the activity of digestive amylase in fish. Group II (3.35±0.19U) and Group III (3.49±0.13 U) were recorded with reduced glucose-6-phosphatase activities than the control group (4.4±0.39 U). Moreover, the study revealed a decline in fructose-1,6-phosphatase activities in the treated groups in comparison to the control group. The decline in the activities of the metabolic enzymes might be associated with the non-availability of glucose owing to reduced activity of the digestive amylase in the treated groups. In conclusion, the present study established the hypoglycaemic effect of the leaf aqueous extract of M. hexandra in a fish model.

scholarly journals Effect of breakfast fat content on glucose tolerance and risk factors of atherosclerosis and thrombosis

1998 ◽  
Vol 80 (4) ◽  
pp. 323-331 ◽  
Author(s):  
David L. Frape ◽  
Norman R. Williams ◽  
Jayshri Rajput-Williams ◽  
B. W. Maitland ◽  
A. J. Scriven ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Thrombus Formation ◽  
Serum Insulin ◽  
Lipid Fraction ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Oral Glucose ◽  
Significant Treatment ◽  
Treatment Allocation ◽  
Insulin Responses

Twenty-four middle-aged healthy men were given a low-fat high-carbohydrate (5.5 g fat; L), or a moderately-fatty, (25.7 g fat; M) breakfast of similar energy contents for 28 d. Other meals were under less control. An oral glucose tolerance test (OGTT) was given at 09.00 hours on day 1 before treatment allocation and at 13.30 hours on day 29. There were no significant treatment differences in fasting serum values, either on day 1 or at the termination of treatments on day 29. The following was observed on day 29: (1) the M breakfast led to higher OGTT C-peptide responses and higher areas under the curves (AUC) of OGTT serum glucose and insulin responses compared with the OGTT responses to the L breakfast (P< 0.05); (2) treatment M failed to prevent OGTT glycosuria, eliminated with treatment L; (3) serum non-esterified fatty acid (NEFA) AUC was 59% lower with treatment L than with treatment M, between 09.00 and 13.20 hours (P<0.0001), and lower with treatment L than with treatment M during the OGTT (P= 0.005); (4) serum triacylglycerol (TAG) concentrations were similar for both treatments, especially during the morning, but their origins were different during the afternoon OGTT when the Svedberg flotation unit 20–400 lipid fraction was higher with treatment L than with treatment M (P= 0.016); plasma apolipoprotein B-48 level with treatment M was not significantly greater than that with treatment L (P= 0.086); (5) plasma tissue plasminogen-activator activity increased after breakfast with treatment L (P= 0.0008), but not with treatment M (P= 0.80). Waist:hip circumference was positively correlated with serum insulin and glucose AUC and with fasting LDL-cholesterol. Waist:hip circumference and serum TAG and insulin AUC were correlated with factors of thrombus formation; and the OGTT NEFA and glucose AUC were correlated. A small difference in fat intake at breakfast has a large influence on circulating diurnal NEFA concentration, which it is concluded influences adversely glucose tolerance up to 6 h later.

scholarly journals Serum Glucose Level and Hemoglobin Concentration in Third Trimester of Pregnancy

2016 ◽  
Vol 10 (2) ◽  
pp. 67-70
Author(s):  
Sumaira Sufrin ◽  
Akhtarun Nessa ◽  
Md Tazul Islam
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Glucose Level ◽  
Hemoglobin Concentration ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Control Group ◽  
Third Trimester ◽  
Cross Sectional ◽  
Altered Glucose

Background : Pregnancy is a state of physiological adaptations to accommodate the needs of the developing fetus. Elevated blood glucose during pregnancy could lead to gestational diabetes and anemia could cause intercurrent infection.Objective: To assess the serum glucose level & hemoglobin concentration in third trimester of pregnancy in order to find out the risk of gestational diabetes and physiological anemia.Method: This cross-sectional study was carried out in the Department of Physiology Mymensingh Medical College, Mymensingh, between the period of July, 2013 to June,2014. One hundred pregnant women in their third trimester of pregnancy aged 18-35years were enrolled in study group and age matched 100 healthy non-pregnant women were control group. Random serum glucose was estimated by GOD-PAP method and hemoglobin concentration was measured by cyanmethemoglobin (CMG) method. Data were analyzed by student’s un paired t test and chi square test.Result: Mean serum glucose level (6.76±1.72 mmol/L) was significantly higher and hemoglobin concentration (8.21±1.23 g/dl) was significantly lower in pregnant women than non-pregnant women. Increased frequency of high glucose (38%) and low H b(88%) was found in pregnant women in third trimester.Conclusion: This study concludes altered glucose metabolism may lead to gestational diabetes as well as physiological anemia may be exaggerated in third trimester of pregnancyBangladesh Soc Physiol. 2015, December; 10(2): 67-70

The N-terminal alanine-extended GLP-1/IgG-Fc fusion protein confers resistance to DPP-IV and reduces serum glucose level in db/db mice

2011 ◽  
Vol 170 (1-3) ◽  
pp. 1-3 ◽  
Author(s):  
Hye-Shin Chung ◽  
Ji-Yeon Oh ◽  
Seung-Bum Yoo ◽  
Sang Mee Lee ◽  
Heung-Soo Cho
Keyword(s):  
Fusion Protein ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Dpp Iv ◽  
Fc Fusion Protein

scholarly journals Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.

2021 ◽  
Vol 19 (3) ◽  
pp. 02-17
Author(s):  
Aditya Dilipkumar Patil ◽  
Charusheela Dilipkumar Patil ◽  
Dilipkumar Kondiba Patil
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Holistic Approach ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Treatment Of Diabetes

INTRODUCTION – Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathy a science of ultra-molecular doses with a holistic approach is used in treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum, Pancreatinum and Uranium nitricum is used in homeopathy for treatment of Diabetes Mellitus. However no any preclinical studies have been investigated for the anti-diabetic effect and its safety. METHODS – Homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in 6C (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days treatment bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) was measured. RESULTS – After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p

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