scholarly journals Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

2007 ◽  
Vol 4 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Derrick Lonsdale
Keyword(s):  
Clinical Setting ◽  
Case Reports ◽  
Clinical Applications ◽  
Therapeutic Use ◽  
Transketolase Activity ◽  
Thiamin Pyrophosphate ◽  
Cofactor Deficiency

Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effect (TPPE), indicating intracellular cofactor deficiency, usually improves with thiamin administration. Biochemical correction of the abnormality is, however, invariably dependent on the provision of other NCN, especially magnesium. In two patients reported here, this correction required several infusions containing magnesium and other NCN administered intravenously. In a third patient, hemoconcentration associated with an abnormal TPPE was normalized after administration of nutrients that included thiamin and magnesium.

scholarly journals Clinical Indications and Compassionate Use of Phage Therapy: Personal Experience and Literature Review with a Focus on Osteoarticular Infections

Viruses ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 18 ◽  
Author(s):  
Olivier Patey ◽  
Shawna McCallin ◽  
Hubert Mazure ◽  
Max Liddle ◽  
Anthony Smithyman ◽  
...  
Keyword(s):  
Phage Therapy ◽  
Case Reports ◽  
Individual Case ◽  
Clinical Applications ◽  
Experimental Therapy ◽  
Compassionate Use ◽  
Osteoarticular Infections ◽  
Antibiotic Failure ◽  
Historical Accounts ◽  
Number Of Treatment

The history of phage therapy started with its first clinical application in 1919 and continues its development to this day. Phages continue to lack any market approval in Western medicine as a recognized drug, but are increasingly used as an experimental therapy for the compassionate treatment of patients experiencing antibiotic failure. The few formal experimental phage clinical trials that have been completed to date have produced inconclusive results on the efficacy of phage therapy, which contradicts the many successful treatment outcomes observed in historical accounts and recent individual case reports. It would therefore be wise to identify why such a discordance exists between trials and compassionate use in order to better develop future phage treatment and clinical applications. The multitude of observations reported over the years in the literature constitutes an invaluable experience, and we add to this by presenting a number of cases of patients treated compassionately with phages throughout the past decade with a focus on osteoarticular infections. Additionally, an abundance of scientific literature into phage-related areas is transforming our knowledge base, creating a greater understanding that should be applied for future clinical applications. Due to the increasing number of treatment failures anticipatedfrom the perspective of a possible post-antibiotic era, we believe that the introduction of bacteriophages into the therapeutic arsenal seems a scientifically sound and eminently practicable consideration today as a substitute or adjuvant to antibiotic therapy.

Routine Clinical Applications of Hemodialysis-Hemoperfusion in Chronic Renal Failure: Case Reports

1986 ◽  
Vol 9 (5) ◽  
pp. 305-308 ◽  
Author(s):  
P.E. Barré ◽  
A. Gonda ◽  
T.M.S. Chang
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Peripheral Neuropathy ◽  
Activated Charcoal ◽  
Case Reports ◽  
Hematological Parameters ◽  
Cost Effective ◽  
Hemodialysis Patients ◽  
Clinical Applications ◽  
Dialysis Time

Five hemodialysis patients were treated with combined hemodialysis-hemoperfusion with their conventional hemodialyzer plus a 70-gram ultrathin collodion coated activated charcoal device for a total of 63 months. Indications for this therapy included pericarditis, peripheral neuropathy, clotting of conventional hemodialyzers and reduction of dialysis time and frequency. The outcome was beneficial in all cases and stable biochemical and hematological parameters were maintained. No increase in heparin requirements was noted and the therapy was thought to be cost-effective.

Applications of platelet- rich plasma (prp) in contemporary pediatric dentistry

2006 ◽  
Vol 30 (4) ◽  
pp. 283-286 ◽  
Author(s):  
N. Shashikiran ◽  
V. Subba Reddy ◽  
C. Yavagal ◽  
M Zakirulla
Keyword(s):  
Growth Factors ◽  
Present Article ◽  
Bone Grafting ◽  
Platelet Rich Plasma ◽  
Case Reports ◽  
Pediatric Dentistry ◽  
Clinical Applications ◽  
Current Evidence ◽  
Invaluable Tool

Current evidence and understanding of bone science recognize the pivotal role of growth factors in all the aspects of bone grafting and regeneration. Platelet-rich-plasma (PRP) is one of the richest sources of growth factors to enhance bone regeneration. The present article aims to highlight the basic mechanisms involved in the successful use of PRP and its clinical applications in Pediatric dentistry based on our case-reports citing its use for bone grafting in young children. With pertinence to its current advantages and recent applications, PRP could soon prove to be an invaluable tool for pediatric dental surgeons worldwide.

scholarly journals The role of actigraphy in sleep medicine

2021 ◽  
Author(s):  
Jens G. Acker ◽  
C. Becker-Carus ◽  
Antje Büttner-Teleaga ◽  
Werner Cassel ◽  
Heidi Danker-Hopfe ◽  
...  
Keyword(s):  
Present Article ◽  
Clinical Setting ◽  
Cost Effective ◽  
Sleep Medicine ◽  
Clinical Applications ◽  
Objective Data ◽  
Wide Acceptance ◽  
Wrist Actigraphy ◽  
The Cost

AbstractActigraphy has been used for more than 60 years to objectively measure sleep–wake rhythms. Improved modern devices are increasingly employed to diagnose sleep medicine disorders in the clinical setting. Although less accurate than polysomnography, the chief advantage of actigraphs lies in the cost-effective collection of objective data over prolonged periods of time under everyday conditions. Since the cost of wrist actigraphy is not currently reimbursed, this method has not enjoyed wide acceptance to date. The present article provides an overview of the main clinical applications of actigraphy, including the recommendations of specialist societies.

scholarly journals Clinical applications of the jugal lipectomy technique: case reports

2018 ◽  
Vol 5 (3) ◽  
pp. 11
Author(s):  
Bárbara do Amaral Antunes ◽  
Allan Robert Moreira Schmitt ◽  
Michel Abrão Neto ◽  
Filipe Jaeguer ◽  
Maria da Graça Naclério-Homem ◽  
...  
Keyword(s):  
Case Reports ◽  
Clinical Applications
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