scholarly journals Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract

2006 ◽  
Vol 3 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Chihiro Tohda ◽  
Natsuki Nakayama ◽  
Fumiyuki Hatanaka ◽  
Katsuko Komatsu
Keyword(s):  
Adjuvant Arthritis ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Curcuma Longa ◽  
Curcuma Zedoaria ◽  
Inhibitory Effects ◽  
Serum Haptoglobin ◽  
Haptoglobin Concentration ◽  
Anti Inflammatory ◽  
Curcuma Kwangsiensis

We aimed to compare the anti-inflammatory activities of six species ofCurcumadrugs using adjuvant arthritis model mice. When orally administered 1 day before the injection of adjuvant, the methanol extract ofCurcuma phaeocaulissignificantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. Also when orally administered 1 day after the injection of adjuvant, the methanol extract ofCurcuma phaeocaulissignificantly inhibited paw swelling. OtherCurcumaspecies (Curcuma longa, Curcuma wenyujin, Curcuma kwangsiensis, Curcuma zedoariaandCurcuma aromatica) had no significant inhibitory effects on adjuvant-induced paw swelling. Cyclooxygenase (COX)-2 activity was significantly inhibited by the methanol extract ofC. phaeocaulis. Curcuminoids' (curcumin, bis-demethoxycurcumin and demethoxycurcumin) were rich inC. longa, but less inC. phaeocaulisandC. aromatica, not inC. wenyujin, C. kwangsiensisandC. zedoaria, suggesting that curcuminoids' contents do not relate to inhibition of arthritis swelling. Therefore,C. phaeocaulismay be a useful drug amongCurcumaspecies for acute inflammation, and the active constituents ofC. phaeocaulisare not curcuminoids.

scholarly journals Chemical Constituents of Vigna luteola and Their Anti-inflammatory Bioactivity

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1371 ◽  
Author(s):  
Sio-Hong Lam ◽  
Yue-Chiun Li ◽  
Ping-Chung Kuo ◽  
Tsong-Long Hwang ◽  
Mei-Lin Yang ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Mass Spectrometric ◽  
Inhibitory Effects ◽  
Potential Evaluation ◽  
Anti Inflammatory ◽  
Vigna Luteola

Seventy-three compounds were identified from the methanol extract of V. luteola, and among these, three new (1–3) were characterized by spectroscopic and mass spectrometric analyses. The isolated constituents were assessed for anti-inflammatory potential evaluation, and several purified principles exhibited significant superoxide anion and elastase inhibitory effects.

scholarly journals Effects of Methanol Extract of Piper chaba Stem Bark on Acute Inflammation in rats

2012 ◽  
Vol 7 (1) ◽  
pp. 26-28
Author(s):  
F Begum ◽  
ZA Begum ◽  
MR Uddin ◽  
AHMZ Haider ◽  
RC Barman
Keyword(s):  
Body Weight ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Oedema Formation ◽  
Medicinal Value ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The plant Piper chaba Hunter (Piperaceae), a climbing glabrous shrub grows in plenty in southern Bangladesh. Popularly known as 'Choi' it is used as spices and believed to have medicinal value in a wide variety of disease conditions including arthritis, asthma, bronchitis and piles. In the present study, effect of methanol extract of Piper chaba stem bark on acute inflammation has been reported. The anti-inflammatory effect was studied in rats by injecting 0.1ml of 1% carrageenan suspension into the planter surface, where oedema of the rat's hind paw was used as an index of acute inflammation. Methanol extract of Piper chaba stem bark given orally 1 hour before injection at doses of 125 and 250 mg/kg body weight, produced significant (p< 0.05) anti inflammatory effect compared to control and the percentage of inhibition of oedema formation was 33% and 35% respectively, which however was less compared to aspirin (46%) and hydrocortisone (56%). The result suggest that in case of acute inflammation, Piper chaba stem bark possess mild to moderate anti inflammatory effect compared to that of aspirin and hydrocortisone.DOI: http://dx.doi.org/10.3329/fmcj.v7i1.10294Faridpur Med. Coll. J. 2012;7(1): 26-28

scholarly journals Effects of Methanol Extract of Piper chaba Stem Bark on Chronic Inflamation in Rats

1970 ◽  
Vol 2 (2) ◽  
pp. 37-39 ◽  
Author(s):  
Fouzia Begum ◽  
Kamal Uddin ◽  
Syeeda Sultana ◽  
Abul Hasnat Ferdous ◽  
Zinnat Ara Begum
Keyword(s):  
Chronic Inflammation ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Granuloma Formation ◽  
Medicinal Value ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Implantation Method ◽  
Inflammatory Effect

Piper chaba Hunter (Piperaceae), a climbing glabrous shrub grows in plenty in southern Bangladesh. Popularly known as ‘Choi' it is used as spices and believed to have medicinal value in a wide variety of disease conditions including arthritis, asthma, bronchitis and piles. Earlier studies on methanol extract of Piper chaba stem bark have reported anti-inflammatory activities against acute inflammation. In the present study, effect of methanol extract of Piper chaba stem bark on chronic inflammation has been reported. The anti-inflammatory effect was studied in rats using cotton pellet implantation method, where granuloma formation was used as an index of chronic inflammation. Methanol extracts of Piper chaba stem bark given orally for 14 days daily at doses of 125 and 250 mg/kg body weight produced statistically significant (p < 0.05 and p < 0.01) anti-inflammatory effect compared to control. The percent inhibition of granuloma formation was 25% and 28% respectively, which however was less compared to aspirin (41%) and hydrocortisone (58%). The results suggest that in case of chronic inflammation, Piper chaba stem bark possess mild to moderate anti-inflammatory effect compared to that of aspirin and hydrocortisone. Ibrahim Med. Coll. J. 2008; 2(2): 37-39 Key Words: Rats, chronic inflammation, Piper chaba, aspirin, hydrocortisone, choi   doi: 10.3329/imcj.v2i2.2934

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Mollik ◽  
W Mozammel Haq ◽  
S Chandra Bachar ◽  
R Jahan ◽  
M Rahmatullah
Keyword(s):  
Curcuma Longa ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WM Shaik Mossadeq ◽  
K Syamimi ◽  
MP Azyyati ◽  
ZA Zakaria ◽  
AK Arifah ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Methanol Extract ◽  
Guinea Pig Ileum ◽  
Mitragyna Speciosa ◽  
Anti Inflammatory ◽  
Crude Methanol Extract ◽  
Inflammatory Effect

Anti-inflammatory Effect of Allium hookeri Root Methanol Extract in LPS-induced RAW264.7 Cells

2012 ◽  
Vol 41 (11) ◽  
pp. 1645-1648 ◽  
Author(s):  
Chang-Hyun Kim ◽  
Mi-Ai Lee ◽  
Tae-Woon Kim ◽  
Ja Young Jang ◽  
Hyun Ju Kim
Keyword(s):  
Methanol Extract ◽  
Raw264.7 Cells ◽  
Allium Hookeri ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Inhibitory Effects of Myelophycus simplex Papenfuss Methanol Extract on Melanogenesis in B16F10 Melanoma Cells

2017 ◽  
Vol 46 (1) ◽  
pp. 34-38
Author(s):  
Hyang Suk Kim ◽  
Ji Min Cheon ◽  
Da Hye Kwon ◽  
Eun Ok Choi ◽  
Min Ju Kim ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Melanoma Cells ◽  
Inhibitory Effects ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cells
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