The clinical significance of hypercontractile peristalsis: comparison of high-resolution manometric features, demographics, symptom presentation, and response to therapy in patients with Jackhammer esophagus versus Nutcracker esophagus

2017 ◽  
Vol 30 (12) ◽  
pp. 1-7 ◽  
Author(s):  
M. T. Al-Qaisi ◽  
H. A. Siddiki ◽  
M. D. Crowell ◽  
G. E. Burdick ◽  
D. E. Fleischer ◽  
...  
Keyword(s):  
High Resolution ◽  
Clinical Significance ◽  
Response To Therapy ◽  
Symptom Presentation ◽  
Nutcracker Esophagus

M1575 The Clinical Significance of Elevated Esophageal Contraction Amplitudes: A High Resolution Manometric Study of “Nutcracker” Esophagus

2009 ◽  
Vol 136 (5) ◽  
pp. A-899 ◽  
Author(s):  
Marek Polomsky ◽  
Boris Sepesi ◽  
Virginia R. Litle ◽  
Daniel Raymond ◽  
Carolyn E. Jones ◽  
...  
Keyword(s):  
High Resolution ◽  
Clinical Significance ◽  
Nutcracker Esophagus ◽  
Manometric Study ◽  
Esophageal Contraction

Normal variations of the temporal bone on high-resolution CT: Their incidence and clinical significance

1995 ◽  
Vol 50 (3) ◽  
pp. 144-148 ◽  
Author(s):  
N. Tomura ◽  
R. Sashi ◽  
M. Kobayashi ◽  
H. Hirano ◽  
M. Hashimoto ◽  
...  
Keyword(s):  
High Resolution ◽  
Temporal Bone ◽  
Clinical Significance ◽  
High Resolution Ct

Sa1327 High-Resolution Manometry Assessment of the Lower-Esophageal Sphincter Aftercontraction: Normative Values and Clinical Significance

2016 ◽  
Vol 150 (4) ◽  
pp. S283-S284
Author(s):  
Dustin A. Carlson ◽  
Peter Kahrilas ◽  
Zoe Listernick ◽  
Yinglian Xiao ◽  
Vadim Bul ◽  
...  
Keyword(s):  
High Resolution ◽  
Lower Esophageal Sphincter ◽  
Clinical Significance ◽  
Normative Values ◽  
High Resolution Manometry ◽  
Esophageal Sphincter

Clinical Significance of p53 and bcl-2 Protein Coexpression Phenotypes in Molecular Breast Cancer Subtypes of Pre-menopausal and Post-menopausal African-American Women

2009 ◽  
Vol 75 (9) ◽  
pp. 776-784 ◽  
Author(s):  
Chukwuemeka U. Ihemelandu ◽  
Robert L. Dewitty ◽  
Lasalle D. Leffall ◽  
Siram M. Suryanarayana ◽  
Wayne A. Frederick
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Clinical Significance ◽  
Basal Cell ◽  
Prognostic Significance ◽  
Response To Therapy ◽  
Breast Cancer Subtypes ◽  
American Women ◽  
Cancer Subtypes

With the current classification of breast carcinoma into molecular subtypes with distinct prognosis and response to therapy, we sort to assess the clinical significance of p53 and bcl-2 coexpression phenotypes in invasive breast tumors and correlate this to the different molecular breast cancer subtypes in African-American women. We performed a retrospective analysis of data on p53 and bcl-2 expression. Results were correlated to molecular breast cancer subtypes, and clinicopathologic variables of prognostic significance. Our study sample included all African-American women diagnosed with breast cancer from 1998 to 2005. Twenty-seven (27.6%) per cent of cases in our study sample over-expressed p53, whereas 69.3 per cent over-expressed bcl-2 protein. A significant inverse correlation was observed between expression of p53 and bcl-2. Combined analysis of p53 and bcl-2 showed that 53.2 per cent of the tumors displayed p53(-)bcl-2(+) phenotype which was significantly associated with the luminal A subtype, whereas 11.6 per cent displayed the p53(+)bcl-2(-) phenotype which was significantly associated with the basal cell-like and Her-2/neu. Neither p53 expression nor bcl-2 expression individually or in combination were of independent prognostic significance. p53(+)bcl-2(-) phenotype is significantly correlated with the basal cell-like subtype and may be associated with the biologic aggressiveness of this cohort of molecular breast cancer.

scholarly journals Detection and Differentiation of Two Koala Gammaherpesviruses by Use of High-Resolution Melt (HRM) Analysis Reveals Differences in Viral Prevalence and Clinical Associations in a Large Study of Free-Ranging Koalas

2019 ◽  
Vol 57 (3) ◽  
Author(s):  
P. K. Vaz ◽  
A. R. Legione ◽  
C. A. Hartley ◽  
J. M. Devlin
Keyword(s):  
High Resolution ◽  
Clinical Significance ◽  
Large Scale ◽  
Diagnostic Methods ◽  
High Resolution Melt ◽  
Phascolarctos Cinereus ◽  
Content Type ◽  
Island Populations ◽  
Chlamydia Pecorum ◽  
The Individual

ABSTRACTThe iconic koala (Phascolarctos cinereus) is host to two divergent gammaherpesviruses, phascolarctid gammaherpesviruses 1 and 2 (PhaHV-1 and -2), but the clinical significance of the individual viruses is unknown and current diagnostic methods are unsuitable for differentiating between the viruses in large-scale studies. To address this, we modified a pan-herpesvirus nested PCR to incorporate high-resolution melt analysis. We applied this assay in a molecular epidemiological study of 810 koalas from disparate populations across Victoria, Australia, including isolated island populations. Animal and clinical data recorded at sampling were analyzed and compared to infection status. Between populations, the prevalence of PhaHV-1 and -2 varied significantly, ranging from 1% to 55%. Adult and older animals were 5 to 13 times more likely to be positive for PhaHV-1 than juveniles (P< 0.001), whereas PhaHV-2 detection did not change with age, suggesting differences in how these two viruses are acquired over the life of the animal. PhaHV-1 detection was uniquely associated with the detection of koala retrovirus, particularly in females (P= 0.008). Both viruses were significantly associated (P< 0.05) with the presence of genital tract abnormalities (uterine/ovarian cysts and testicular malformation), reduced fertility in females, urinary incontinence, and detection ofChlamydia pecorum, although the strength of these associations varied by sex and virus. Understanding the clinical significance of these viruses and how they interact with other pathogens will inform future management of threatened koala populations.

Sign in / Sign up

Export Citation Format

Share Document