Surgical outcomes of two different reconstruction routes for esophagectomy in esophageal cancer patients: a meta-analysis

2021 ◽  
Author(s):  
Dongqing Yan ◽  
Hongjie Zheng ◽  
Peijie Wang ◽  
Yin Yin ◽  
Qiwei Zhang ◽  
...  
Keyword(s):  
Anastomotic Leakage ◽  
Surgical Outcomes ◽  
Meta Analysis ◽  
Postoperative Mortality ◽  
Case Control ◽  
Pulmonary Complications ◽  
Anastomotic Stenosis ◽  
Cardiac Complications ◽  
Case Control Studies ◽  
Significant Difference

Summary To evaluate the effects of two different reconstruction routes (the posterior mediastinal route (PR) and the retrosternal route (RR)) on the surgical outcomes of patients after esophagectomy for esophageal carcinoma. PubMed, Embase, Web of Science and Scopus were searched from database inception to March 2021. Randomized controlled trials (RCTs) and case–control trials on the surgical outcomes of patients undergoing esophagectomy via one of the two routes were included. RevMan 5.3 software was used for the meta-analysis. In total, 19 studies were included, 8 were RCTs and 11 were case–control studies. The meta-analysis showed that among the case–control trials, the PR had reduced rates of anastomotic leakage [odds ratio (OR) = 0.56, 95% confidence interval (CI) (0.43, 0.74), P < 0.01]. In addition, it had reduced rates of anastomotic stenosis [OR = 0.42, 95% CI (0.30, 0.59), P < 0.01] and pulmonary complications [OR = 0.63, 95% CI (0.47, 0.84), P < 0.01]. However, there was no significant difference in cardiac complications [RCTs, relative risk (RR) = 0.57, 95% CI (0.29, 1.11), P = 0.10; case–control trials, OR = 1.06, 95% CI (0.70, 1.62), P = 0.78] or postoperative mortality [RCTs, RR = 0.47, 95% CI (0.19, 1.16), P = 0.10; case–control trials, OR = 0.68, 95% CI (0.32, 1.44), P = 0.31]. Compared with the RR, the PR had reduced rates of anastomotic leakage, anastomotic stenosis and pulmonary complications.

Factors affecting color stability of maxillofacial prosthetic silicone elastomer: A systematic review and meta-analysis

2020 ◽  
pp. 009524432094679 ◽  
Author(s):  
Farah Rashid ◽  
Aparna Barman ◽  
Taseef Hasan Farook ◽  
Nafij Bin Jamayet ◽  
Mohd Firdaus Bin Yhaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Color Stability ◽  
Case Control ◽  
Nano Particles ◽  
Silicone Elastomer ◽  
Blue Pigment ◽  
Red Pigment ◽  
Case Control Studies ◽  
Significant Difference

Purpose: This systematic review and meta-analysis explored the factors involved in the color stability and degradation of Maxillo-Facial Prosthetic Silicone Elastomer (MFPSE). Further exploration was done to analyze past literature discussing the potential benefits to color stability when nano-particles were combined with pigmented MFPSE. Method: The search for the articles was done according to PRISMA guidelines. Articles were searched from “Scopus” and “Web of Sciences” from the year 1970 to 2019. Searches were carried out by two reviewers until November 2019. Articles for systematic review were selected based on predefined eligibility criteria. Information regarding weathering conditions, pigments and filler-particle inclusion were extracted as appropriate. Further screening was done for meta-analyze case-control studies of red, blue and yellow pigments according to predefined scoring criteria. Meta-analysis was conducted on case-control studies that incorporated 5%,10% and 15% TiO2 in MFPSE with the said pigments and was carried out using Cochrane Review Manager 5.3. Results: 30 studies were selected for systematic review and 6 studies were eligible for meta-analysis. The most prominent influencers of color stability were nano-fillers and the type of color used in the mixing. Furthermore, experimental conditions, weathering, color of investment plaster and the method of color detection all affected the degree of degradation. There was an overall significant difference found when TiO2 was incorporated with the pigmented silicone. There is significant difference when 10% ( P = 0.0004) TiO2 is incorporated with the red pigment, 5% ( P = 0.03) TiO2 with the yellow and 10% ( P < 0.0001) and 15% ( P = 0.02) TiO2 with the blue pigment. Conclusion: Type of pigment and nano-filler incorporated into the silicone play a role in influencing color stability. Incorporation of 10% TiO2 with red pigment,5% with yellow pigment and 10% or 15% TiO2 with blue pigment provided some protection to the silicone elastomer from color degradation.

scholarly journals Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Li ◽  
Li Sun ◽  
Jinghui Sun ◽  
Min Yan
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Genetic Effect ◽  
Analysis Data ◽  
Case Control ◽  
Case Control Studies ◽  
Significant Difference ◽  
Meta Analyses ◽  
The Impact

Abstract Background The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis. Methods We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (Passociation) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models. Results Compared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted Passociation > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted Passociation > 0.05). Besides, data of Begg’s and Egger’s tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results. Conclusion The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.

scholarly journals Neuromelanin-Sensitive Magnetic Resonance Imaging in Schizophrenia: A Meta-Analysis of Case-Control Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Lara Wieland ◽  
Sophie Fromm ◽  
Stefan Hetzer ◽  
Florian Schlagenhauf ◽  
Jakob Kaminski
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Meta Analysis ◽  
Case Control ◽  
Primary Study ◽  
Resonance Imaging ◽  
Case Control Studies ◽  
Significant Difference

Background: Psychiatry is in urgent need of reliable biomarkers. Novel neuromelanin-sensitive magnetic resonance imaging (NM-MRI) sequences provide a time-efficient and non-invasive way to investigate the human brain in-vivo. This gives insight into the metabolites of dopaminergic signaling and may provide further evidence for potential dopaminergic alterations in patients with schizophrenia (SCZ). The present systematic review provides a meta-analysis of case-control studies using neuromelanin-sensitive sequences in SCZ vs. healthy controls (HC).Methods: According to predefined search terms and inclusion criteria studies were extracted on PubMed. Meta-analyses with a fixed and random-effects model with inverse variance method, DerSimonian-Laird estimator for τ2, and Cohen's d were calculated. Bias was assessed using funnel plots. The primary study outcome was contrast-to-noise ratio (CNR) in the substantia nigra compared between HC and SCZ.Results: The total sample of k = 6 studies included n = 183 cases and n = 162 controls. Across all studies we found a significant elevation of CNR in the substantia nigra (d = 0.42 [0.187; 0.655], z = 3.521, p &lt; 0.001) in cases compared to controls. We found no significant difference in the control region of locus coeruleus (d = −0.07 [−0.446; 0.302], z = −0.192, p = 0.847), with CNR for the latter only reported in k = 3 studies.Conclusion: CNR in the substantia nigra were significantly elevated in cases compared to controls. Our results support neuromelanin as a candidate biomarker for dopaminergic dysfunction in schizophrenia. Further studies need to assess this candidate marker in large, longitudinal cohorts and address potential effects of disease state, medication and correlations with symptoms.

scholarly journals The Association Between the Gut Microbiota and Systemic Lupus Erythematosus, a Meta-Analysis

2021 ◽  
Author(s):  
Shate XIANG ◽  
Yiqian Qu ◽  
Suhai Qian ◽  
Yao Wang ◽  
Yibo Jin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gut Microbiota ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Case Control ◽  
Healthy People ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
Significant Difference

Abstract Introduction: Evaluate the changes of gut Microbiota in patients with Systemic Lupus Erythematosus (SLE) and healthy people by meta-analysis. Methods We searched the case-control studies of SLE and healthy controls (HCs) for detecting the diversity of gut Microbiota and the abundance level of some microbiota in the two groups. StataMP16 software was applied for this meta-analysis. The Newcastle-Ottawa quality assessment scale (NOS) was used to assess the quality of the included studies. Results Eleven case-control studies were included. There were 373 SLE patients and 1288 healthy people, involving 5 countries and 9 different cities. Compared with the HCs, the Shannon-wiener diversity index (WMD=-0.22; 95% CI=-0.32 to -0.13; P = 0.000) and Chao1 richness estimator (SMD=-0.62; 95% CI=-1.04 to -0.21; P = 0.003) of gut Microbiota in SLE decreased, and the abundance level of Ruminococcaceae decreased (SMD=--0.48; 95% CI = 0.76 to-0.21; P = 0.001). Enterobacteriaceae (SMD = 0.39,95% CI = 0.11 to 0.66;P = 0.006) and Enterococcaceae (SMD = 0.55; 95% CI = 0.19 to 0.9; P = 0.03) showed higher abundance levels in comparison with HCs. The subgroup analysis showed the abundance level of Ruminococcaceae (SMD=-0.89; 95% CI =-1.34 to -0.45; P = 0.000) was lower and Enterococcaceae was higher (SMD = 0.77; 95% CI = 0.34 to 1.21༛P = 0.001) in Chinese with SLE compared with HCs. In non-Chinese patients with SLE, there were no significant difference between the abundance level of Ruminococcaceae (SMD=-0.22; 95% CI=--0.58 to 0.13; P = 0.216) and Enterococcaceae (SMD=-0.08; 95% CI=-0.49 to 0.32; P = 0.682 ) with HCs. The subgroup analysis also found the level of Enterobacteriaceae was affected by the sample size. Conclusion Compared with the diversity of healthy people, richness and evenness of gut microbiota in patients with SLE are impaired. There is a decrease in the abundance level of beneficial bacteria and an increase in the harmful bacteria. Thus, gut microbiota in patients with SLE appear disorder, which may lead to metabolic imbalance, destruction of the integrity of the small intestine, immune system disorders and pro-inflammatory. Regulating the abundance of gut microbiota can be used as one of the key strategies for treating SLE.

scholarly journals Relationship betweenHelicobacter pyloriinfection and osteoporosis: a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e027356 ◽  
Author(s):  
Taiwu Wang ◽  
Xiang Li ◽  
Qi Zhang ◽  
Bingjie Ge ◽  
Jinhai Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Biomedical Literature ◽  
Sensitivity Analyses ◽  
Case Control Studies ◽  
Mineral Density ◽  
Significant Difference ◽  
H Pylori

ObjectivesMany studies have explored the association betweenHelicobacter pyloriinfection and osteoporosis. However, the results remain controversial. Therefore, we performed this systematic review and meta-analysis to evaluate the association betweenH. pyloriinfection and osteoporosis.DesignSystematic review and meta-analysis of case–control studies.Data sourcesDatabases, including PubMed, Embase, Web of Science and Chinese Biomedical Literature Database, were screened from inception to 30 April 2018.Eligibility criteriaCase–control studies aimed at assessing the association betweenH. pyloriinfection and osteoporosis.Data extraction and analysisStudy characteristics and study quality sections were reviewed. Studies were selected, and data were extracted by two reviewers. Pooled ORs and 95% CIs were calculated using random effects model if heterogeneity existed; otherwise, fixed effects model was used. Subgroup analyses were performed to explore the source of heterogeneity. Publication bias and sensitivity analyses were also tested.ResultsA total of 21 studies with 9655 participants were included in our analyses. Taking together, we found thatH. pyloriinfection was associated with increased odds of osteoporosis (OR (95% CI): 1.39 (1.13 to 1.71)); there was no significant difference between osteoporosis and osteopaenia; the association between osteoporosis andH. pyloriinfection was relatively higher in men than women but did not reach significant level. However, the decrease of bone mineral density inH. pylori-positive patients was not significant when compared withH. pylorinegative controls, which may due to the sample size.ConclusionsOur meta-analysis suggests an association between osteoporosis andH. pyloriinfection. The clinicians should pay more attention to the patients infected withH. pylori. Further studies were still needed to exploring the confounding factors among studies and to elucidate the underlying biological mechanisms.

scholarly journals A meta-analysis of serum osteocalcin level in postmenopausal osteoporotic women compared to controls

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhongyu Liu ◽  
Ruiqiang Chen ◽  
Yutong Jiang ◽  
Yang Yang ◽  
Lei He ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Significant Difference ◽  
High Bone ◽  
Study Population

Abstract Background Circulatory osteocalcin (OC) has been widely used as a biomarker to indicate bone turnover status in postmenopausal osteoporosis (PMO). However, the change of serum OC (sOC) level in PMO cases compared to postmenopausal controls remains controversial. Methods We searched the online database of PubMed and Cochrane Library. A meta-analysis of case-control studies was performed to compare the pooled sOC level between PMO patients and postmenopausal controls. Subgroup analysis according to potential confounding factors (different OC molecules and regions of the study population) was also performed. Results Ten case-control studies with 1577 postmenopausal women were included in this meta analysis. We found no significant difference in the pooled sOC level [mean difference (MD) = 1.84, 95% confidence interval (CI): (− 1.49, 5.16), p = 0.28] between PMO patients and controls. Subgroup analysis also revealed no significant difference in intact OC [MD = 1.76, 95%CI: (− 1.71, 5.23), p = 0.32] or N-terminal mid-fragment of the OC molecule [MD = 0.67, 95%(− 5.83, 7.18), p = 0.84] between groups. For different regions, no significant difference in sOC was found in Asian population between cases and controls [MD = -0.06, 95%(− 6.02, 5.89), p = 0.98], while the pooled sOC level was significantly higher in European PMO cases than controls [MD = 3.15, 95%(0.90, 5.39), p = 0.006]. Conclusions Our analysis revealed no significant difference in sOC level between PMO cases and controls according to all the current eligible studies. OC molecules are quite heterogeneous in the circulation and can be influenced by glucose metabolism. Therefore, sOC is currently not a good indicator for the high bone turnover status in PMO. More trials with standardized methodologies for the evaluation of circulatory OC are awaited to update our current findings.

scholarly journals Meta-Analysis: Overweight, Obesity, and Parkinson's Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jinhu Chen ◽  
Zhenlong Guan ◽  
Liqin Wang ◽  
Guangyao Song ◽  
Boqing Ma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Overweight And Obesity ◽  
Case Control Studies ◽  
Therapeutic Implications ◽  
Cockroach Allergen ◽  
Significant Difference ◽  
Relationship Of

Objective.Parkinson's disease (PD) is a severe neurological disease and its risk factors remain largely unknown. A meta-analysis was carried out to investigate the relationship of overweight and obesity with PD.Methods.We used PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) databases to identify studies of associations between overweight/obesity and PD. Overweight, obesity, and PD were used as keywords, and published works were retrieved until September 30, 2013. The extracted data were classified(BMI≥30,25≤BMI<30,  and BMI<25)according to BMI values and analyzed using RevMan5.2 and Stata11.0.Results.Four cohort studies and three case-control studies were used to evaluate the association between overweight/obesity and PD, including 2857 PD patients and 5, 683, 939 cases of non-PD controls. There was a statistically significant difference between25≤BMI<30  and BMI<25in the cohort study (RR=1.17, 95%CI, 1.03–1.32,  P=0.03), but there was no difference betweenBMI≥30  and BMI<25orBMI≥30  and 25≤BMI<30, where the respectiveRRwas 1.16 and 0.84; the respective 95%CIwas 0.67–2.01 and 0.61–1.15, respectively, and thePvalues were 0.60 and 0.28, respectively. Case-control studies showed that there was no statistical difference between any two groups.Conclusion.Meta-analysis showed that overweight might be a potential risk factor of PD. Demonstration of a causal role of overweight/obesity in PD development could have important therapeutic implications.Erratum to “Sensitization to Cockroach Allergen: Immune Regulation and Genetic Determinants”

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