scholarly journals Feasibility, tolerability, and effects of exercise-based prehabilitation after neoadjuvant therapy in esophagogastric cancer patients undergoing surgery: an interventional pilot study

2020 ◽  
Author(s):  
Núria Argudo ◽  
Anna Rodó-Pin ◽  
Juana Martínez-Llorens ◽  
Ester Marco ◽  
Laura Visa ◽  
...  
Keyword(s):  
Exercise Training ◽  
Neoadjuvant Therapy ◽  
Exercise Capacity ◽  
High Intensity ◽  
Locally Advanced ◽  
Interval Training ◽  
Successful Implementation ◽  
Positive Effects ◽  
Esophagogastric Cancer ◽  
High Intensity Interval

ABSTRACT Patients requiring surgery for locally advanced esophagogastric cancer often require neoadjuvant therapy (NAT), which may have a detrimental impact on cardiorespiratory reserve. The aims of this study were to investigate the feasibility and tolerability of a 5-week preoperative high-intensity interval training program after NAT, and to assess the potential effects of the training protocol on exercise capacity, muscle function, and health-related quality of life (HRQL). We prospectively studied consecutive patients with resectable locally advanced esophageal and gastric cancer in whom NAT was planned (chemo- or chemoradiotherapy). Feasibility was assessed with the TELOS (Technological, Economics, Legal, Operational, and Scheduling) components, and data on exercise tolerability (attendance and occurrence of adverse or unexpected events). Exercise capacity was assessed with peak oxygen uptake (VO2peak) in a cardiopulmonary exercise test at baseline, post-NAT, and following completion of a high-intensity interval exercise training (25 sessions). Changes in muscle strength and HRQL were also assessed. Of 33 recruited subjects (mean age 65 years), 17 received chemoradiotherapy and 16 chemotherapy. All the TELOS components were addressed before starting the intervention; from a total of 17 questions considered as relevant for a successful implementation, seven required specific actions to prevent potential concerns. Patients attended a mean of 19.4 (6.4) exercise sessions. The predefined level of attendance (≥15 sessions of scheduled sessions) was achieved in 27 out of 33 (81.8%) patients. Workload progression was adequate in 24 patients (72.7%). No major adverse events occurred. VO2peak decreased significantly between baseline and post-NAT (19.3 vs. 15.5 mL/Kg/min, P < 0.05). Exercise led to a significant improvement of VO2peak (15.5 vs. 19.6 mL/kg/min, P < 0.05). Exercise training was associated with clinically relevant improvements in some domains of HRQL, with the social and role function increasing by 10.5 and 11.6 points, respectively, and appetite loss and fatigue declining by 16 and 10.5, respectively. We conclude that a structured exercise training intervention is feasible and safe following NAT in patients with esophagogastric cancer, and it has positive effects to restore exercise capacity to baseline levels within 5 weeks with some improvements in HRQL.

Effects of high-intensity interval training and flaxseed oil supplement on learning, memory and immobility: relationship with BDNF and TrkB genes

2020 ◽  
pp. 1-12
Author(s):  
S. Rahmati-Ahmadabad ◽  
M.-A. Azarbayjani ◽  
D.R. Broom ◽  
M. Nasehi
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Executive Functions ◽  
High Intensity ◽  
Interval Training ◽  
Flaxseed Oil ◽  
High Intensity Interval Training ◽  
Positive Effects ◽  
High Intensity Interval ◽  
Positive Effect

This study examined the independent and combined effects of high-intensity interval training (HIIT) and flaxseed oil supplementation on cognitive/executive functions in middle-aged rats. Hippocampal neurotropic brain factor (BDNF) and tyrosine kinase receptor B (TrkB) gene expression were also measured. Animals were randomly divided into groups including no exercise control and saline (CS), no exercise control and flaxseed oil supplement (CF), exercise training-and saline (TS) and exercise training and flaxseed oil supplement (TF). The training groups undertook a program of HIIT (10 weeks, five sessions per week) and the supplement groups received flaxseed oil supplement (300 mg/kg). The results showed that HIIT and flaxseed oil supplementation independently had positive effects on memory and learning (P<0.05). HIIT and flaxseed oil independently decreased immobility behaviour and increased hippocampal BDNF and TrkB genes expression (P<0.05). HIIT and flaxseed oil combination had a greater effect on some variables (hippocampal TrkB gene expression, memory and immobility) compared to each intervention alone (P<0.05). In conclusion, HIIT and flaxseed oil can independently improve cognitive/executive functions. In addition, HIIT had a greater positive effect than flaxseed oil supplementation on memory and immobility. The combination of HIIT and flaxseed oil supplement had a more positive effect compared to each intervention alone on memory, and immobility. Hippocampal BDNF gene expression did not significantly differ in the combination or independent groups. Thus, future work is needed on several other genes in different segments of the brain to find the additive-mechanisms involved in memory and immobility regulation and younger and older species of rat should be examined.

High intensity interval training reduces systemic inflammation in post-PCI patients

2011 ◽  
Vol 18 (6) ◽  
pp. 850-857 ◽  
Author(s):  
Peter Scott Munk ◽  
Unni Mathilde Breland ◽  
Pål Aukrust ◽  
Thor Ueland ◽  
Jan Terje Kvaløy ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Exercise Training ◽  
Stable Angina ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Cell Activation ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Endothelial Cell Activation ◽  
High Intensity Interval

Background: Increased plasma levels of inflammatory markers and markers of endothelial cell activation have been associated with increased risk for cardiovascular events. Exercise training may lower the risk for coronary heart disease by attenuating inflammation and improving endothelial function. The objective of this study was to evaluate effects of regular high-intensity exercise training on a wide range of markers of inflammation and endothelial cell activation. Materials and methods: Consecutively, 40 patients were prospectively randomized to a 6 months supervised high-intensity interval training programme or to a control group following successful percutaneous coronary intervention (PCI). Blood samples of 36 patients with stable angina, drawn at baseline (before PCI) and at 6 months, were analysed. Late luminal loss was measured at 6 months using quantitative coronary angiography. Results: At 6 months, levels of the inflammatory markers interleukin (IL)-6 and IL-8 were reduced and levels of the anti-inflammatory cytokine IL-10 increased in the training group only. The decrease in IL-6 and C-reactive protein levels were significantly correlated with the decrease in luminal loss following PCI. In contrast to these anti-inflammatory effects, training had no effect on markers of platelet-mediated inflammation, and the effect of training on markers on endothelial cell activation were rather complex showing attenuating (von Willebrand factor) and enhancing (E-selectin and vascular cell adhesion molecule 1) effects. Conclusions: Regular exercise training in stable angina patients following PCI may attenuate some, but not all, inflammatory pathways, potentially contributing to the beneficial effects of exercise training on restenosis.

scholarly journals Personalized Moderate-Intensity Exercise Training Combined with High-Intensity Interval Training Enhances Training Responsiveness

2019 ◽  
Vol 16 (12) ◽  
pp. 2088 ◽  
Author(s):  
Bryant R. Byrd ◽  
Jamie Keith ◽  
Shawn M. Keeling ◽  
Ryan M. Weatherwax ◽  
Paul B. Nolan ◽  
...  
Keyword(s):  
Resistance Training ◽  
Exercise Training ◽  
Training Program ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
Z Score ◽  
High Intensity Interval Training ◽  
Resistance Training Program ◽  
High Intensity Interval

This study sought to determine if personalized moderate-intensity continuous exercise training (MICT) combined with high-intensity interval training (HIIT) was more effective at improving comprehensive training responsiveness than MICT alone. Apparently healthy, but physically inactive men and women (n = 54) were randomized to a non-exercise control group or one of two 13-week exercise training groups: (1) a personalized MICT + HIIT aerobic and resistance training program based on the American Council on Exercise guidelines, or (2) a standardized MICT aerobic and resistance training program designed according to current American College of Sports Medicine guidelines. Mean changes in maximal oxygen uptake (VO2max) and Metabolic (MetS) z-score in the personalized MICT + HIIT group were more favorable (p < 0.05) when compared to both the standardized MICT and control groups. Additionally, on the individual level, there were positive improvements in VO2max (Δ > 4.9%) and MetS z-score (Δ ≤ −0.48) in 100% (16/16) of participants in the personalized MICT + HIIT group. In the present study, a personalized exercise prescription combining MICT + HIIT in conjunction with resistance training elicited greater improvements in VO2max, MetS z-score reductions, and diminished inter-individual variation in VO2max and cardiometabolic training responses when compared to standardized MICT.

The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers

2015 ◽  
Vol 21 (3) ◽  
Author(s):  
Sajad Ahmadizad ◽  
Alireza Salimi Avansar ◽  
Khosrow Ebrahim ◽  
Mohsen Avandi ◽  
Mansour Ghasemikaram
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Weight Management ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Tnf Α ◽  
High Intensity Interval

AbstractExercise training is an effective method of weight management, and knowing about its influence on the hormones involved in the regulation of food intake and inflammation could be useful for body weight management. Therefore, the purpose of this study was to compare the effects of 6 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT) on nesfatin-1, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α).Thirty sedentary overweight men (Mean±SD; age, 25±1 years) were divided into three (n=10) body mass index-matched groups. The participants in the training groups performed either HIIT or MCT protocols 3 days per week for 6 weeks followed by a week of detraining.Plasma IL-6 and TNF-α did not significantly change after training, but nesfatin increased significantly only with HIIT compared with the control group (p<0.05). In addition, fasting glucose, insulin, and homeostasis model estimated insulin resistance (HOMA-IR), decreased significantly following both HIIT and MCT training (p<0.05). After a detraining period, the plasma nesfatin-1 did not return to pre-training levels in the HIIT group.Both the HIIT and MCT groups had similar effects on inflammatory markers and insulin resistance in men who are overweight, but the HIIT seems to have better anorectic effects (as indicated by nesfatin) compared with MCT.

scholarly journals Effects of High Intensity Interval Training on Executive Function in Children Aged 8–12 Years

2019 ◽  
Vol 16 (21) ◽  
pp. 4127 ◽  
Author(s):  
Nobuaki Tottori ◽  
Noriteru Morita ◽  
Kenji Ueta ◽  
Satoshi Fujita
Keyword(s):  
Executive Function ◽  
Physical Fitness ◽  
High Intensity ◽  
Digit Span ◽  
Interval Training ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Tower Of Hanoi ◽  
Positive Effects ◽  
High Intensity Interval

This study investigated the effects of a high intensity interval training (HIIT) program on both physical fitness and executive functions in children. Fifty-six children aged 8–12 years participated in this study, and were divided into a HIIT group and a control group. The HIIT group performed three sessions of the 8- to 10-min HIIT program per week for 4 weeks. Before and after the intervention, 20-m shuttle runs, sit-ups, and standing long jumps were assessed as test of physical fitness. In addition, the executive function was assessed using the digit span forward (DSF) test, digit span backward (DSB) test, and Tower of Hanoi test. Only the HIIT group experienced significant improvement when completing the 20-m shuttle run (p = 0.042) and sit-ups (p < 0.001). Regarding executive function, the number of correct answers in DSB test significantly increased only in the HIIT group (p = 0.003). However, the standing long jump, DSF, and the Tower of Hanoi test performance did not change after intervention. The findings of the present study suggest that HIIT has positive effects on a core executive function such as working memory in addition to components of the physical fitness such as cardiorespiratory endurance and muscular endurance.

scholarly journals Exercise training in heart failure: role, prescription and program

2018 ◽  
Vol 38 (4) ◽  
pp. 226-233
Author(s):  
Raymond Pranata ◽  
Emir Yonas ◽  
Bambang B. Siswanto ◽  
Budhi S. Purwowiyoto
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Exercise Training ◽  
High Intensity ◽  
Exercise Prescription ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
High Intensity Interval

Heart failure is one of the most common cardiovascular diseases and is a final pathway of various cardiac pathologies. Exercise intolerance and dyspnea accompanied by dete­riorating quality of life are common issues in those suffering from heart failure and may persist despite optimal medical therapy. Exercise training in heart failure theoretically helps to slow down the deterioration of the heart by antagonizing excess neurohormonal activity in heart failure, which translated into better functional capacity and quality of life. Exercise prescription is a mean of assessing and interpreting clinical information and applying the principles of training to develop an appropriate regimen and should be tailored to patient’s clinical condition. Resistance training improves peak VO2, exercise capacity and quality of life in heart failure patients. Both continuous and interval exercise training are linked to better quality of life despite ambiguous results in mortality. The aim of this article is to discuss the benefits of exercise in patients with congestive heart failure, exercise prescription, and exercise program including high-intensity interval training, continuous training and resistance exercise.   Abstrak Gagal jantung adalah salah satu penyakit kardiovaskular yang paling sering ditemui dan merupakan akhir daripada banyak jenis patologi jantung. Intoleransi olahraga dan sesak nafas disertai dengan memburuknya kualitas hidup merupakan beberapa masalah yang sering dihadapi oleh pasien gagal jantung, meskipun telah diberikan pengobatan yang optimal. Latihan olahraga pada gagal jantung secara teoritis dapat memperlambat menurunnya fungsi jantung dengan melawan aktivitas neurohormonal yang meningkat pada kondisi gagal jantung yang dicerminkan dengan kapasitas fungsional dan kualitas hidup yang lebih baik. Preskripsi olahraga meliputi pemeriksaan dan interpretasi dari informasi klinis dan aplikasi dari prinsip latihan untuk membentuk regimen yang sesuai dan harus di sesuaikan dengan keadaan klinis pasien. Latihan beban memperbaiki fungsi VO2 puncak, kapasitas olahraga dan kualitas hidup pada pasien dengan gagal jantung. Kedua metode olahraga baik secara kontinu ataupun interval dihubungkan dengan kualitas hidup yang lebih baik meskipun masih ambigu dalam hal mortalitas. Tujuan artikel ini adalah membahas manfaat latihan fisik pada pasien dengan gagal jantung kongestif, cara peresepan serta membahas program high intensity interval training, continuous training serta latihan beban.

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