Early diagnosis of mucosal squamous cell carcinoma of the esophagus: including two interesting cases of superficial spreading-type and multicentric-type squamous cell carcinomas

1997 ◽  
Vol 10 (3) ◽  
pp. 201-205
Author(s):  
H. Kimura ◽  
K. Konishi ◽  
M. Earashi ◽  
T. Satou ◽  
N. Nojima ◽  
...  
Digestion ◽  
2019 ◽  
Vol 101 (3) ◽  
pp. 239-244
Author(s):  
Tatsuo Yachida ◽  
Ichiro Oda ◽  
Seiichiro Abe ◽  
Masau Sekiguchi ◽  
Satoru Nonaka ◽  
...  

2001 ◽  
Vol 96 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Norihiro Yuasa ◽  
Masahiko Miyachi ◽  
Akihiro Yasui ◽  
Naokazu Hayakawa ◽  
Tatsuo Hattori ◽  
...  

2021 ◽  
pp. 11-14
Author(s):  
T.D. Bubliy ◽  
L.I. Voloshina ◽  
L.I. Dubovaya

Oral squamous cell carcinoma is the most prevalent manifestations of malignant tumors in the cranial and cervical regions and they cannot be frequently established until symptoms appear. So there is an urgent need to device methods for the detection of oral premalignant lesions and oral cancer at an early stage in order to improve further patients’ conditions. The whole world was suddenly affected the uncontrolled spread of the coronavirus. All spheres of life were affected, especially medicine. The strict quarantine for 2 months created problems for the patients. Patients who needed dental care they also suffered from it. Dental medical institutions provided only emergency medical care during the period of quarantine restrictions. The planned treatment was postponed until the quarantine restrictions stopped. In fact, the entire population of the country was in a state of significant psycho-emotional stress. This was combined with the state of chronic stress, and influenced the number of cancers. This trend can be traced worldwide. According to the literature, in the United States, squamous cell carcinoma of the oral cavity takes 3% of all cancers in men and 2% in women. The tendency of this disease in people 50 years older observed all over the world, however, the disease occurs in people aged 32-49 years. About 40% of intraoral squamous cell carcinomas begin on the floor of the mouth or on the lateral and ventral surfaces of the tongue. About 38% of all oral squamous cell carcinomas occur on the lower lip; these are usually solar-related cancers on the external surface. The symptoms of this disease in the initial stages are absolutely nonspecific. Many patients do not attach importance to them. Quarantine restrictions on the provision of advisory assistance make this problem of particular relevance. The authors of the article have determined that their goal to attract the attention of dentists and family doctors to the problem of early diagnosis of oncological diseases and oral cancer is enough important nowadays. Early, curable lesions are rarely symptomatic; thus, preventing fatal disease requires early detection by screening. The main goal for such investigations is to attract the attention of dentists and family doctors to the problem of early diagnosis of cancer, including oral cavity. The article presents the clinical characteristics of squamous cell carcinoma of the oral cavity. Particularly, doctors should pay attention to the variety of symptoms characteristic of the initial period of the disease. Patients may complain of thickening of the tissues of the oral cavity, the presence of white spots, ulcerative lesions, which may be covered with plaque. Slight painful sensations are distinguished as manifestations of other diseases. Sometimes the symptoms are relieved by taking analgesics. Patients self-medicate and postpone visiting a specialized specialist for an indefinite time. This does not trouble both patients and some health workers. It should be noted that a typical symptom in the developed period is fetid odor from the mouth due to decay and infection of the tumor. Oral lesions are asymptomatic initially, highlighting the need for oral screening. Most dental professionals carefully examine the oral cavity and oropharynx during routine care and may do a brush biopsy of abnormal areas. The lesions may appear as areas of erythroplakia or leukoplakia and may be exophytic or ulcerated. Cancers are often indurated and firm with a rolled border. As the lesions increase in size, pain, dysarthria, and dysphagia may result. During the period of neglect, cancer of the oral cavity organs quickly spreads and destroys the surrounding tissues, infiltrates the floor of the oral cavity, palatine arches, pharynx, etc. To illustrate the problems outlined in the article, the authors took a clinical case that combines the problems of early diagnosis of oral cancers. It should be noted that in addition to the “inactivity” of the patient in solving problems that occurred in the oral cavity, the resolution of the situation was inhibited by the introduced quarantine measures.


2021 ◽  
Vol 22 (6) ◽  
pp. 2831
Author(s):  
Ryan Bensen ◽  
John Brognard

Squamous cell carcinomas of the lung, head and neck, esophagus, and cervix account for more than two million cases of cancer per year worldwide with very few targetable therapies available and minimal clinical improvement in the past three decades. Although these carcinomas are differentiated anatomically, their genetic landscape shares numerous common genetic alterations. Amplification of the third chromosome’s distal portion (3q) is a distinguishing genetic alteration in most of these carcinomas and leads to copy-number gain and amplification of numerous oncogenic proteins. This area of the chromosome harbors known oncogenes involved in squamous cell fate decisions and differentiation, including TP63, SOX2, ECT2, and PIK3CA. Furthermore, novel targetable oncogenic kinases within this amplicon include PRKCI, PAK2, MAP3K13, and TNIK. TCGA analysis of these genes identified amplification in more than 20% of clinical squamous cell carcinoma samples, correlating with a significant decrease in overall patient survival. Alteration of these genes frequently co-occurs and is dependent on 3q-chromosome amplification. The dependency of cancer cells on these amplified kinases provides a route toward personalized medicine in squamous cell carcinoma patients through development of small-molecules targeting these kinases.


2021 ◽  
Vol 28 (3) ◽  
pp. 1886-1898
Author(s):  
Christian Flörke ◽  
Aydin Gülses ◽  
Christina-Randi Altmann ◽  
Jörg Wiltfang ◽  
Henning Wieker ◽  
...  

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.


2015 ◽  
Vol 105 (4) ◽  
pp. 374-376
Author(s):  
Morteza Khaladj ◽  
Rose-Mary Mbibong ◽  
Nisha Shah ◽  
Ayesha Mohiuddin ◽  
Aqsa Siddiqui

Squamous cell carcinomas are often seen on the sun-exposed areas of the skin and are rarely observed on the digits of the foot. However, there have been incidences of squamous cell carcinoma developing in the presence of chronic wounds with osteomyelitis, thus complicating the treatment. We present a patient with osteomyelitis who developed invasive squamous cell carcinoma of the third digit. We conclude that wounds with osteomyelitis may have underlying pathologic abnormalities that are not obvious on initial presentation.


1997 ◽  
Vol 4 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Paul L. Baron ◽  
Christopher E. Gates ◽  
Carolyn E. Reed ◽  
Roberta L. D. Dikeman ◽  
Jay J. Drosieko ◽  
...  

2012 ◽  
Vol 75 (4) ◽  
pp. AB484
Author(s):  
Toshiro Iizuka ◽  
Daisuke Kikuchi ◽  
Akihiro Yamada ◽  
Osamu Ogawa ◽  
Masanori Nakamura ◽  
...  

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