scholarly journals Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications

Database ◽  
2015 ◽  
Vol 2015 (0) ◽  
pp. bav056-bav056 ◽  
Author(s):  
T. Heged s ◽  
P. M. Chaubey ◽  
G. Varady ◽  
E. Szabo ◽  
H. Saranko ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Proteome Analysis ◽  
Membrane Proteome ◽  
Red Blood Cell Membrane ◽  
Diagnostic Applications

scholarly journals Pharmaco-Proteomic Study of Hydroxyurea-Induced Modifications in the Sickle Red Blood Cell Membrane Proteome

2008 ◽  
Vol 233 (12) ◽  
pp. 1510-1517 ◽  
Author(s):  
Swati S. Ghatpande ◽  
Pankaj K. Choudhary ◽  
Charles T. Quinn ◽  
Steven R. Goodman
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Membrane Proteome ◽  
Red Blood Cell Membrane ◽  
Proteomic Study

P1-350: Red blood cell membrane proteome is altered in Alzheimer's subjects

2008 ◽  
Vol 4 ◽  
pp. T321-T321
Author(s):  
Joy G. Mohanty ◽  
Hemant D. Shukla ◽  
Satya Saxena ◽  
Jefferey D. Williamson ◽  
Lenore J. Launer ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Membrane Proteome ◽  
Red Blood Cell Membrane

scholarly journals In vivo pharmaco-proteomic analysis of hydroxyurea induced changes in the sickle red blood cell membrane proteome

2010 ◽  
Vol 73 (3) ◽  
pp. 619-626 ◽  
Author(s):  
Swati S. Ghatpande ◽  
Pankaj K. Choudhary ◽  
Charles T. Quinn ◽  
Steven R. Goodman
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Proteomic Analysis ◽  
Membrane Proteome ◽  
Red Blood Cell Membrane ◽  
Induced Changes

scholarly journals Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology

2010 ◽  
Vol 8 (1) ◽  
pp. 11 ◽  
Author(s):  
Joy G Mohanty ◽  
Hem D Shukla ◽  
Jefferey D Williamson ◽  
Lenore J Launer ◽  
Satya Saxena ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Cell Morphology ◽  
Red Blood Cell ◽  
Membrane Proteome ◽  
Red Blood Cell Membrane ◽  
Altered Cell ◽  
Insight Into

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

scholarly journals Direct Measurement of the Area Expansion and Shear Moduli of the Human Red Blood Cell Membrane Skeleton

2001 ◽  
Vol 81 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Guillaume Lenormand ◽  
Sylvie Hénon ◽  
Alain Richert ◽  
Jacqueline Siméon ◽  
François Gallet
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Direct Measurement ◽  
Red Blood Cell ◽  
Membrane Skeleton ◽  
Shear Moduli ◽  
Red Blood Cell Membrane ◽  
Area Expansion
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