scholarly journals Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction

2012 ◽  
Vol 97 (3) ◽  
pp. 464-471 ◽  
Author(s):  
Nazha Hamdani ◽  
Kalkidan G. Bishu ◽  
Marion von Frieling-Salewsky ◽  
Margaret M. Redfield ◽  
Wolfgang A. Linke
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Preserved Ejection Fraction ◽  
Experimental Heart Failure ◽  
And Function

scholarly journals Comorbidity and Ventricular and Vascular Structure and Function in Heart Failure With Preserved Ejection Fraction

2012 ◽  
Vol 5 (6) ◽  
pp. 710-719 ◽  
Author(s):  
Selma F. Mohammed ◽  
Barry A. Borlaug ◽  
Véronique L. Roger ◽  
Sultan A. Mirzoyev ◽  
Richard J. Rodeheffer ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Structure And Function ◽  
Vascular Structure ◽  
Preserved Ejection Fraction ◽  
And Function

Abstract 13641: Serum Vitamin D3 Levels, Left Ventricular Structure and Incident Hospitalization for Heart Failure With Preserved Ejection Fraction in African Americans: The Jackson Heart Study

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Daisuke Kamimura ◽  
Amil M Shah ◽  
Adebamike Oshunbade ◽  
Arsalan Hamid ◽  
Robert Mentz ◽  
...  
Keyword(s):  
Heart Failure ◽  
African Americans ◽  
Ejection Fraction ◽  
Serum Vitamin ◽  
Left Ventricular ◽  
Structure And Function ◽  
Preserved Ejection Fraction ◽  
Lower Serum ◽  
Heart Study ◽  
And Function

Background: Lower serum vitamin D3 (VitD3) concentration has been associated with cardiovascular disease. However, the associations between serum VitD3 levels and left ventricular (LV) structure and function and heart failure with preserved ejection fraction (HFpEF) have not been well-characterized community. The prevalence of VitD3 deficiency is higher among African Americans than in other race/ethnicity groups. We hypothesized that serum VitD3 levels are associated with LV concentric remodeling and incident heart failure (HF) in African Americans. Methods and Results: Among 4872 African Americans in the Jackson Heart Study cohort, we investigated the relationships between serum VitD3 levels and LV structure and function, evaluated with echocardiography, and incident HF hospitalization, categorized either HF with reduced EF (HFrEF: EF<50%) or HFpEF (EF≥50%). The median and interquartile serum VitD3 levels were 12.0 (8.6-16.7) ng/mL. After adjustment for age, sex, body mass index, systolic blood pressure, anti-hypertensive medication use, current smoking status, and estimated glomerular filtration rate, lower VitD3 levels were associated with greater septal and posterior wall thickness and plasma brain natriuretic peptide (BNP) levels, but not with LV mass index or LVEF (Table). Over a median follow-up period of 11 (10.3~11) years, 313 participants developed incident HF (7.79 cases per 1,000 person-years), including 128 (41%) HFrEF and 185 (59%) HFpEF cases. After adjustment, lower serum VitD3 levels were associated with higher incidence of HF overall and levels seemed to be mostly related to HFpEF (Table). Conclusion: In this community-based African American cohort, lower serum VitD3 levels were associated with LV concentric remodeling and incident HF, mainly HFpEF. Further investigation is required to examine whether the supplementation of VitD3 can prevent LV concentric remodeling and incident HFpEF in African Americans.

scholarly journals Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction

2014 ◽  
Vol 16 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Mauro Gori ◽  
Carolyn S. P. Lam ◽  
Deepak K. Gupta ◽  
Angela B. S. Santos ◽  
Susan Cheng ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Structure And Function ◽  
Preserved Ejection Fraction ◽  
Cardiovascular Structure ◽  
And Function

scholarly journals Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction

2014 ◽  
Vol 7 (1) ◽  
pp. 104-115 ◽  
Author(s):  
Amil M. Shah ◽  
Sanjiv J. Shah ◽  
Inder S. Anand ◽  
Nancy K. Sweitzer ◽  
Eileen O’Meara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Preserved Ejection Fraction ◽  
Cardiac Structure And Function ◽  
And Function

scholarly journals Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction

2014 ◽  
Vol 7 (5) ◽  
pp. 740-751 ◽  
Author(s):  
Amil M. Shah ◽  
Brian Claggett ◽  
Nancy K. Sweitzer ◽  
Sanjiv J. Shah ◽  
Inder S. Anand ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Preserved Ejection Fraction ◽  
Cardiac Structure And Function ◽  
And Function
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