The Relationship of Renal Blood Flow to Cardiac Output in Normal Individuals as Determined by Concomitant Radioisotopic Measurements

1968 ◽  
Vol 2 (3) ◽  
pp. 243-246 ◽  
Author(s):  
R. E. Botti ◽  
M. A. Razzak ◽  
W. J. MacIntyre ◽  
W. H. Pritchard
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Renal Blood Flow ◽  
Normal Individuals ◽  
Relationship Of ◽  
The Relationship

THE RELATIONSHIP OF THE UREA CLEARANCE TO THE RENAL BLOOD FLOW

1934 ◽  
Vol 110 (2) ◽  
pp. 387-391 ◽  
Author(s):  
D. D. Van Slyke ◽  
C. P. Rhoads ◽  
Alma Hiller ◽  
Alf Alving
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Urea Clearance ◽  
Relationship Of ◽  
The Relationship

Autoregulation of renal blood flow in the rat: effects of growth and uninephrectomy

1983 ◽  
Vol 244 (5) ◽  
pp. F483-F487 ◽  
Author(s):  
R. L. Chevalier ◽  
D. L. Kaiser
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Young Animal ◽  
Normal Growth ◽  
Sham Operation ◽  
Adult Rats ◽  
Arterial Blood ◽  
Relationship Of ◽  
The Relationship

As a result of normal maturation or after reduction in renal mass, renal blood flow (RBF) progressively increases. However, the effects of renal growth on the relationship of RBF to renal perfusion pressure (RPP) have not been systematically investigated. We examined RBF as a function of RPP in anesthetized young and adult rats that had been subjected to uninephrectomy or sham operation 3-4 wk previously. As a result of normal growth, mean arterial blood pressure increased from 94.1 +/- 2.7 (SE) to 118.9 +/- 4.2 mmHg. The calculated autoregulation factor, in which a value less than 1 indicates the presence of autoregulation, was 0.44 +/- 0.10 over RPP 70-100 mmHg and 1.74 +/- 0.25 over RPP 40-70 mmHg in sham-operated young animals. In adult sham-operated rats, the factor was 0.38 +/- 0.07 over RPP 100-130 mmHg and 1.03 +/- 0.07 over RPP 70-100 mmHg. Uninephrectomy in adults resulted in a 30% rise in RBF over RPP 100-130 mmHg, and there was no change in the autoregulation factor. Uninephrectomy in young rats, however, resulted in a 35% rise in RBF at RPP = 100 mmHg with only a 17% rise at RPP = 70 mmHg, and the autoregulation factor increased to 0.91 +/- 0.10 over this range of RPP. We conclude that the autoregulatory range shifts with increasing blood pressure during normal growth and that autoregulation is "reset" to higher RBF in the uninephrectomized adult rat. Although autoregulation takes place in the young animal, uninephrectomy alters the relationship of RBF to RPP such that autoregulation is impaired.

Mannitol diuresis: The relationship of plasma volume to renal blood flow

1965 ◽  
Vol 5 (12) ◽  
pp. 552-555 ◽  
Author(s):  
Don E. Detmer ◽  
Jack M. Zimmerman ◽  
Thomas C. King
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Plasma Volume ◽  
Relationship Of ◽  
The Relationship

Haemodynamic Characteristics of Low-Renin Hypertension

1977 ◽  
Vol 52 (4) ◽  
pp. 405-412 ◽  
Author(s):  
M. A. D. H. Schalekamp ◽  
W. H. Birkenhäger ◽  
G. A. Zaal ◽  
G. Kolsters
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Renal Blood Flow ◽  
Vascular Resistance ◽  
Plasma Renin ◽  
Renal Vascular Resistance ◽  
Plasma Renin Concentration ◽  
Low Renin Hypertension ◽  
Renal Vascular ◽  
The Relationship

1. Intra-arterial pressure, cardiac output, renal blood flow and glomerular filtration rate were measured in 19 patients with low-renin hypertension and in 30 patients with normal-renin hypertension. 2. Cardiac output and renal blood flow were significantly lower in low-renin hypertension. Total peripheral and renal vascular resistance were markedly higher in this group. 3. Plasma renin concentration correlated inversely with both total peripheral and renal vascular resistance as well as with age. Multiple regression analysis indicated that part of the relationship between renin and haemodynamic variables did not depend on age. Furthermore, plasma renin concentration did not decrease with age in a group of 40 normotensive control subjects of similar age to the hypertensive patients. 4. The results provide further confirmation that renin decreases as hypertension progresses.

Effects of acute uninephrectomy and age on renal blood flow autoregulation in the rat

1985 ◽  
Vol 249 (5) ◽  
pp. F672-F679 ◽  
Author(s):  
R. L. Chevalier ◽  
D. L. Kaiser
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Renal Perfusion ◽  
Compensatory Hypertrophy ◽  
Hemodynamic Changes ◽  
Adult Rats ◽  
Compensatory Renal Growth ◽  
Relationship Of ◽  
The Relationship ◽  
Renal Blood Flow Autoregulation

We previously showed that renal autoregulatory behavior is modified by both normal and compensatory renal growth. To determine whether the hemodynamic changes precede an increase in renal mass, the relationship of renal blood flow (RBF) to renal perfusion pressure (RPP) was examined in the remaining kidney of anesthetized young and adult rats 30 min following contralateral nephrectomy. In young control animals 32-41 days old, an autoregulation factor (AF) of 0.37 +/- 0.10 (SE) over RPP 70-100 mmHg indicates efficient autoregulation and did not change during the experiment. Acute uninephrectomy in young hydropenic rats resulted in a 16% increase in RBF at normal RPP, and AF increased to 1.22 +/- 0.34 for RPP 70-100 mmHg, reflecting marked impairment of autoregulation. In young animals in which saline infusion was not reduced at the time of uninephrectomy, RBF increased 22% at normal RPP, and autoregulation was similarly impaired (AF 0.92 +/- 0.12 for RPP 70-100 mmHg). Acute uninephrectomy in adult rats resulted in a 13% increase in RBF, with better preservation of AF (0.48 +/- 0.09) over the adult autoregulatory range (RPP 100-130 mmHg). These findings indicate that profound hemodynamic changes take place in the remaining kidney within 30 min of acute uninephrectomy and that they are qualitatively similar to those observed after compensatory hypertrophy has developed.

Relation of blood flow to VO2, PO2, and PCO2 in dog gastrocnemius muscle

1988 ◽  
Vol 255 (5) ◽  
pp. H1004-H1010 ◽  
Author(s):  
D. E. Mohrman ◽  
R. R. Regal
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Gastrocnemius Muscle ◽  
Muscle Blood Flow ◽  
Carbon Dioxide Tension ◽  
Experimental Conditions ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Relationship Of ◽  
The Relationship

We pump-perfused gastrocnemius-plantaris muscle preparations at constant pressure to study the relationship of muscle blood flow (Q) to muscle oxygen consumption (VO2), venous oxygen tension (PVO2), and venous carbon dioxide tension (PVCO2) during steady-state exercise at different rates. Tests were performed under four experimental conditions produced by altering the perfusate blood-gas status with a membrane lung. The consistency of the relationship of Q to other variables was evaluated by statistical analysis of fitted curves. Not one of the above listed variables had the same relationship with Q in all four of the experimental conditions we tested. However, we did find that a consistent relationship existed among Q, PVO2, and PVCO2 in our data. That relationship is well described by the equation (Q-23).[PVO2 - (0.5.PVCO2) - 3] = 105 (when Q is expressed in ml.100 g-1.min-1 and PVO2 and PVCO2 in mmHg). One interpretation of this result is that both PO2 and PCO2 are important variables in the control of blood flow in skeletal muscle the combined influence of which could account for nearly all of the hyperemia response to steady-state muscle exercise.

Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy

1961 ◽  
Vol 200 (6) ◽  
pp. 1169-1176 ◽  
Author(s):  
William E. Huckabee
Keyword(s):  
Blood Flow ◽  
Coronary Flow ◽  
Cardiac Tissue ◽  
Anaerobic Metabolism ◽  
Constant Ratio ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Relationship Of ◽  
The Relationship

Veno-arterial differences of pyruvate and lactate across the myocardium in chloralose-anesthetized dogs were very variable; in any one animal they changed continually with time despite constant blood flow and arterial blood concentrations. There was a systematic tendency of v-a lactate to vary with v-a pyruvate, as expressed in the calculated "Δ excess lactate," which remained nearly constant (or, if blood flow changed, bore a constant ratio to (a-v)O2). No change in Δ excess lactate from control values occurred in nonhypoxic experiments despite marked changes in v-a differences, arterial blood composition, and coronary flow. Cardiac Δ excess lactate became positive in most animals breathing 10% O2 in N2; output of excess lactate was also observed in all those in which moderate muscular exercise was induced. This anaerobic metabolism, or change in the relationship between pyruvate and lactate exchanges, was interpreted as an indication that O2 delivery response was not adequate to meet cardiac tissue requirements during such mild stresses when judged by the standards of adequacy of the basal state.

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