scholarly journals Hypercalcaemia preceding diagnosis of Pneumocystis jirovecii pneumonia in renal transplant recipients

2017 ◽  
Vol 10 (6) ◽  
pp. 845-851 ◽  
Author(s):  
Jonathan Ling ◽  
Tara Anderson ◽  
Sanchia Warren ◽  
Geoffrey Kirkland ◽  
Matthew Jose ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Pneumocystis Jirovecii Pneumonia in Slovenian Renal Transplant Recipients

2012 ◽  
Vol 94 (10S) ◽  
pp. 915
Author(s):  
S. Borstnar ◽  
J. Lindic ◽  
A. Kandus ◽  
J. Tomazic ◽  
A. Pikelj ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Distinct Clinical and Laboratory Patterns of Pneumocystis jirovecii Pneumonia in Renal Transplant Recipients

2021 ◽  
Vol 7 (12) ◽  
pp. 1072
Author(s):  
Andreas M. J. Meyer ◽  
Daniel Sidler ◽  
Cédric Hirzel ◽  
Hansjakob Furrer ◽  
Lukas Ebner ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Clinical Laboratory ◽  
Respiratory Infections ◽  
Laboratory Data ◽  
Total Lymphocyte Count ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Radiological Data

Late post-transplant Pneumocystis jirovecii pneumonia (PcP) has been reported in many renal transplant recipients (RTRs) centers using universal prophylaxis. Specific features of PcP compared to other respiratory infections in the same population are not well reported. We analyzed clinical, laboratory, administrative and radiological data of all confirmed PcP cases between January 2009 and December 2014. To identify factors specifically associated with PcP, we compared clinical and laboratory data of RTRs with non-PcP. Over the study period, 36 cases of PcP were identified. Respiratory distress was more frequent in PcP compared to non-PcP (tachypnea: 59%, 20/34 vs. 25%, 13/53, p = 0.0014; dyspnea: 70%, 23/33 vs. 44%, 24/55, p = 0.0181). In contrast, fever was less frequent in PcP compared to non-PcP pneumonia (35%, 11/31 vs. 76%, 42/55, p = 0.0002). In both cohorts, total lymphocyte count and serum sodium decreased, whereas lactate dehydrogenase (LDH) increased at diagnosis. Serum calcium increased in PcP and decreased in non-PcP. In most PcP cases (58%, 21/36), no formal indication for restart of PcP prophylaxis could be identified. Potential transmission encounters, suggestive of interhuman transmission, were found in 14/36, 39% of patients. Interhuman transmission seems to contribute importantly to PcP among RTRs. Hypercalcemia, but not elevated LDH, was associated with PcP when compared to non-PcP.

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