scholarly journals Rituximab for the treatment of refractory simultaneous anti-glomerular basement membrane (anti-GBM) and membranous nephropathy

2014 ◽  
Vol 7 (1) ◽  
pp. 53-56 ◽  
Author(s):  
G. Bandak ◽  
B. A. Jones ◽  
J. Li ◽  
J. Yee ◽  
K. Umanath
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Membranous Nephropathy

Membranous nephropathy

2010 ◽  
pp. 3985-3988
Author(s):  
Dwomoa Adu
Keyword(s):  
Prostate Cancer ◽  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Basement Membrane ◽  
Autoimmune Diseases ◽  
Outer Surface ◽  
Glomerular Basement Membrane ◽  
Lupus Erythematosus ◽  
Membranous Nephropathy ◽  
Systemic Lupus

Membranous nephropathy, which accounts for 20 to 30% of cases of the nephrotic syndrome in adults, is defined histologically by the presence of subepithelial immune deposits on the outer surface of the glomerular basement membrane. The immune mechanisms that lead to this are uncertain, and most cases are of unknown cause (idiopathic), but the condition can be associated with autoimmune diseases (systemic lupus erythematosus), malignancy (in 10% of cases, most commonly lung and prostate cancer), drugs, and infections....

Evolution of Membranous Nephropathy into Anti-Glomerular-Basement-Membrane Glomerulonephritis

1974 ◽  
Vol 290 (24) ◽  
pp. 1340-1344 ◽  
Author(s):  
John Klassen ◽  
Charles Elwood ◽  
Allan L. Grossberg ◽  
Felix Milgrom ◽  
Mario Montes ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Membranous Nephropathy

scholarly journals Membranous nephropathy followed by anti-glomerular basement disease: A case report and review of clinical presentation and treatment

2018 ◽  
Vol 6 ◽  
pp. 2050313X1880762
Author(s):  
Claudius Speer ◽  
Matthias Martin Gaida ◽  
Rüdiger Waldherr ◽  
Christian Nusshag ◽  
Florian Kälble ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Membranous Nephropathy ◽  
Clinical Presentation ◽  
Rapidly Progressive Glomerulonephritis ◽  
Renal Vein Thrombosis ◽  
Simultaneous Occurrence ◽  
Rapid Decline ◽  
Crescent Formation ◽  
Vein Thrombosis

Membranous nephropathy is a common cause of nephrotic syndrome in adults and can be primary or secondary through autoimmune disease, medication, infection, or malignancy. Rapidly progressive glomerulonephritis with crescent formation is rare in patients with membranous nephropathy. Thus, in cases with rapid decline in renal function, after excluding complications such as malignant hypertension, acute hypersensitivity interstitial nephritis, and bilateral renal vein thrombosis, the simultaneous occurrence of a superimposed glomerulonephritis should be considered. We report a 55-year-old man suffering from a biopsy-confirmed primary membranous nephropathy, who developed rapidly progressive glomerulonephritis with anti-glomerular basement membrane antibodies after being affected with membranous nephropathy for 8 years. The kidney biopsy revealed a concurrence of membranous nephropathy and anti-glomerular basement membrane disease. Clinical presentation and treatment of membranous nephropathy followed by anti-glomerular basement membrane disease are discussed based on our observation with promising follow-up.

scholarly journals Immunoelectron microscopic (IEM) studies on glutaraldehyde-fixed renal specimen.

1984 ◽  
Vol 32 (5) ◽  
pp. 501-509 ◽  
Author(s):  
N Shindo ◽  
E Kobayashi ◽  
M Okada
Keyword(s):  
Basement Membrane ◽  
Light Microscopy ◽  
Glomerular Basement Membrane ◽  
Membranous Nephropathy ◽  
Renal Pathology ◽  
Precise Location ◽  
Routine Diagnosis ◽  
Dense Deposits ◽  
Renal Biopsies ◽  
Glomerular Lesions

Immunofluorescent microscopy (IF) has become an essential tool in the routine diagnosis of renal pathology. It is thought that glomerular IF patterns represent different forms of immunologically mediated glomerular lesions. However, in order to preserve antigenicity IF is usually done on frozen, unfixed specimen by light microscopy and it is difficult to locate target macromolecules in tissue with precision. In order to establish the precise location of such macromolecules in glomeruli in relation to the ultrastructure, we undertook an immunoelectron microscopic (IEM) study on renal biopsies. Percutaneously biopsied tiny specimen was fixed in glutaraldehyde and processed with protease. Using peroxidase-labeled antisera, a direct IEM was done. With this technique, target macromolecules corresponded well not only to electron-dense deposits but also to IF patterns. In one case of membranous nephropathy, immunoglobulin (Ig) was found to be outside of the glomerular basement membrane (GBM), while IgA was seen to be inside the GBM. For this same case, a similar localization of immunoglobulins was not revealed by IF. In conclusion, IEM is a useful technique that can broaden our knowledge of pathogenic mechanisms in glomerular disease.

scholarly journals The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy

2014 ◽  
Vol 85 (4) ◽  
pp. 945-952 ◽  
Author(s):  
Xiao-yu Jia ◽  
Shui-yi Hu ◽  
Jun-liang Chen ◽  
Zhen Qu ◽  
Gang Liu ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Membranous Nephropathy
Sign in / Sign up

Export Citation Format

Share Document