scholarly journals A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus

2018 ◽  
Vol 69 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Jayant V Rajan ◽  
Fred C Semitala ◽  
Tejas Mehta ◽  
Mark Seielstad ◽  
Lani Montalvo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Immunodeficiency Virus ◽  
Whole Blood ◽  
Gene Expression Signature ◽  
Tuberculosis Screening ◽  
Blood Gene Expression ◽  
Expression Signature ◽  
Immunodeficiency Virus

scholarly journals A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

Allergy ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 3248-3260 ◽  
Author(s):  
Nathanaël Lemonnier ◽  
Erik Melén ◽  
Yale Jiang ◽  
Stéphane Joly ◽  
Camille Ménard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Children And Adolescents ◽  
Whole Blood ◽  
Gene Expression Signature ◽  
Blood Gene Expression ◽  
Expression Signature

scholarly journals Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature

2018 ◽  
Vol 172 (10) ◽  
pp. e182293 ◽  
Author(s):  
Victoria J. Wright ◽  
Jethro A. Herberg ◽  
Myrsini Kaforou ◽  
Chisato Shimizu ◽  
Hariklia Eleftherohorinou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kawasaki Disease ◽  
Whole Blood ◽  
Gene Expression Signature ◽  
Blood Gene Expression ◽  
Expression Signature

scholarly journals A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma

2011 ◽  
Vol 4 (10) ◽  
pp. 1599-1608 ◽  
Author(s):  
Melissa Rotunno ◽  
Nan Hu ◽  
Hua Su ◽  
Chaoyu Wang ◽  
Alisa M. Goldstein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Adenocarcinoma ◽  
Whole Blood ◽  
Gene Expression Signature ◽  
Stage I ◽  
Expression Signature

scholarly journals A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials

2019 ◽  
Vol 11 (507) ◽  
pp. eaaw4236 ◽  
Author(s):  
Philip K. Ehrenberg ◽  
Shida Shangguan ◽  
Biju Issac ◽  
Galit Alter ◽  
Aviva Geretz ◽  
...  
Keyword(s):  
Gene Expression ◽  
B Cells ◽  
Vaccine Trial ◽  
Gene Expression Signature ◽  
Gene Signature ◽  
Antibody Responses ◽  
Expression Signature ◽  
Transcriptional Signature ◽  
Correlates Of Protection ◽  
Immunodeficiency Virus

Current HIV vaccines are only partially efficacious, presenting an opportunity to identify correlates of protection and, thereby, potential insight into mechanisms that prevent HIV acquisition. Two independent preclinical challenge studies in nonhuman primates (NHPs) previously showed partial efficacy of a mosaic adenovirus 26 (Ad26)–based HIV-1 vaccine candidate. To investigate the basis of this protection, we performed whole transcriptomics profiling by RNA sequencing (RNA-seq) in sorted lymphocytes from peripheral blood samples taken during these studies at different time points after vaccination but before challenge. We observed a transcriptional signature in B cells that associated with protection from acquisition of simian immunodeficiency virus (SIV) or the simian-human immunodeficiency virus (SHIV) in both studies. Strong antibody responses were elicited, and genes from the signature for which expression was enriched specifically associated with higher magnitude of functional antibody responses. The same gene expression signature also associated with protection in RV144 in the only human HIV vaccine trial to date that has shown efficacy and in two additional NHP studies that evaluated similar canarypox-based vaccine regimens. A composite gene expression score derived from the gene signature was one of the top-ranked correlates of protection in the NHP vaccine studies. This study aims to bridge preclinical and clinical data with the identification of a gene signature in B cells that is associated with protection from SIV and HIV infection by providing a new approach for evaluating future vaccine candidates.

scholarly journals Peripheral blood gene expression signature differentiates children with autism from unaffected siblings

Neurogenetics ◽  
2013 ◽  
Vol 14 (2) ◽  
pp. 143-152 ◽  
Author(s):  
S. W. Kong ◽  
Y. Shimizu-Motohashi ◽  
M. G. Campbell ◽  
I. H. Lee ◽  
C. D. Collins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Gene Expression Signature ◽  
Children With Autism ◽  
Blood Gene Expression ◽  
Expression Signature ◽  
Peripheral Blood Gene Expression
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