scholarly journals Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

2018 ◽  
Author(s):  
Daniel J C Berkhout ◽  
Britt J van Keulen ◽  
Hendrik J Niemarkt ◽  
Jet R Bessem ◽  
Willem P de Boode ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organic Compound ◽  
Preterm Infants ◽  
Volatile Organic Compound ◽  
Late Onset ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Late Onset Sepsis ◽  
Volatile Organic

scholarly journals Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study

Biosensors ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 50 ◽  
Author(s):  
Nancy Deianova ◽  
Sofia el Manouni el Hassani ◽  
Hendrik J. Niemarkt ◽  
Veerle Cossey ◽  
Anton H. van Kaam ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Late Onset ◽  
Mode Of Delivery ◽  
Delivery Mode ◽  
Multicenter Cohort Study ◽  
Diagnostic Biomarkers ◽  
Non Invasive ◽  
Late Onset Sepsis ◽  
Volatile Organic

Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the influence of clinical and environmental factors on the VOC outcome before this technique can be applied in clinical practice. The aim of this study was to investigate the influence of gestational age (GA) and mode of delivery on the fecal VOC pattern in preterm infants born below 30 weeks of gestation. Longitudinal fecal samples, collected on days 7, 14, and 21 postnatally, were analyzed by an electronic nose device (Cyranose 320®). In total, 58 preterm infants were included (29 infants born at GA 24–26 weeks vs. 29 at 27–29 completed weeks, 24 vaginally born vs. 34 via C-section). No differences were identified at any predefined time point in terms of GA and delivery mode (p > 0.05). We, therefore, concluded that correction for these factors in this population is not warranted when performing fecal VOC analysis in the first three weeks of life.

scholarly journals Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study

2021 ◽  
Author(s):  
Mathilde Letouzey ◽  
◽  
Laurence Foix-L’Hélias ◽  
Héloïse Torchin ◽  
Ayoub Mitha ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Preterm Infants ◽  
Late Onset ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

scholarly journals Neonatal Outcomes Following Extensive Delivery Room Resuscitation in Preterm Infants: A Multicenter Cohort Study

2012 ◽  
Vol 17 (suppl_A) ◽  
pp. 30A-30A
Author(s):  
AS Soraisham ◽  
N Singhal ◽  
K Aziz ◽  
A Lodha ◽  
SK Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Neonatal Outcomes ◽  
Delivery Room ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort

scholarly journals The Impact of Postnatal Systemic Steroids on the Growth of Preterm Infants: A Multicenter Cohort Study

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2729
Author(s):  
Carlos Zozaya ◽  
Alejandro Avila-Alvarez ◽  
Fermín García-Muñoz Rodrigo ◽  
María L. Couce ◽  
Luis Arruza ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Invasive Mechanical Ventilation ◽  
Postnatal Growth ◽  
Linear Regression Models ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Major Congenital Malformations ◽  
The Impact

Postnatal steroids, often used to prevent and treat bronchopulmonary dysplasia, may influence the growth of preterm infants, although data are scarce in the literature. This is a multicenter cohort study including surviving preterm infants <32 weeks at birth (n = 17,621) from the Spanish Neonatal Network SEN1500 database, without major congenital malformations. Linear regression models were adjusted for postnatal steroids, respiratory severity course (invasive mechanical ventilation at 28 days), progression to moderate–severe bronchopulmonary dysplasia (O2 at 36 weeks), length of stay, sex, gestational age and z-scores at birth. A subgroup analysis depending on the timing of administration, ventilation status at 28 days and moderate–severe BPD diagnosis was also performed. Overall, systemic postnatal steroids were not independently associated with poorer weight gain (0.1; 95% CI: −0.05 to 0.2 g/kg/day), linear growth (0; 95% CI: −0.03 to 0.01 cm/week) or head circumference growth (−0.01; 95% CI: −0.02 to 0 cm/week). Patients who received steroids after 28 days or who were not O2 dependent at 36 weeks after having received steroids gained more weight (0.22; 95% CI: 0.04 to 0.4 and 0.2; 95% CI: 0.004 to 0.5 g/kg/day, respectively). Globally, systemic postnatal steroids had no significant adjusted effect on postnatal growth.

scholarly journals Epidemiology and microbiology of late-onset sepsis among preterm infants in China, 2015–2018: A cohort study

2020 ◽  
Vol 96 ◽  
pp. 1-9 ◽  
Author(s):  
Siyuan Jiang ◽  
Chuanzhong Yang ◽  
Changyi Yang ◽  
Weili Yan ◽  
Vibhuti Shah ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Late Onset ◽  
Late Onset Sepsis
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