scholarly journals A 4.5-Year Within-Patient Evolution of a Colistin-Resistant Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae Sequence Type 258

2018 ◽  
Vol 67 (9) ◽  
pp. 1388-1394 ◽  
Author(s):  
Agnès B Jousset ◽  
Rémy A Bonnin ◽  
Isabelle Rosinski-Chupin ◽  
Delphine Girlich ◽  
Gaëlle Cuzon ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Sequence Type ◽  
Klebsiella Pneumoniae Carbapenemase

A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

2020 ◽  
pp. 1-4
Author(s):  
Ester Solter ◽  
Jason C. Kwong ◽  
Aaron Walton ◽  
Norelle Sherry ◽  
Benjamin P. Howden ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Common Ancestor ◽  
Sequence Type ◽  
Second Phase ◽  
New Delhi ◽  
Genetic Sequencing ◽  
Klebsiella Pneumoniae Carbapenemase ◽  
Carbapenemase Gene

Abstract We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.

scholarly journals Draft Genome Sequence of a Klebsiella pneumoniae Carbapenemase-Positive Sequence Type 111 Pseudomonas aeruginosa Strain

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Gabrielle A. Dotson ◽  
John P. Dekker ◽  
Tara N. Palmore ◽  
Julia A. Segre ◽  
Sean Conlan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Draft Genome ◽  
Sequence Type ◽  
Draft Genome Sequence ◽  
Positive Sequence ◽  
Gene Encoding ◽  
Klebsiella Pneumoniae Carbapenemase ◽  
Clinical Center

Here, we report the draft genome sequence of a sequence type 111 Pseudomonas aeruginosa strain isolated in 2014 from a patient at the NIH Clinical Center. This P. aeruginosa strain exhibits pan-drug resistance and harbors the bla KPC-2 gene, encoding the Klebsiella pneumoniae carbapenemase enzyme, on a plasmid.

scholarly journals Features of Infections Due to Klebsiella pneumoniae Carbapenemase–Producing Escherichia coli: Emergence of Sequence Type 131

2012 ◽  
Vol 55 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Young Ah Kim ◽  
Zubair A. Qureshi ◽  
Jennifer M. Adams-Haduch ◽  
Yoon Soo Park ◽  
Kathleen A. Shutt ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Sequence Type ◽  
Klebsiella Pneumoniae Carbapenemase

scholarly journals An Emerging Clone, Klebsiellapneumoniae Carbapenemase 2–Producing K. pneumoniae Sequence Type 16, Associated With High Mortality Rates in a CC258-Endemic Setting

2019 ◽  
Vol 71 (7) ◽  
pp. e141-e150 ◽  
Author(s):  
Diego O Andrey ◽  
Priscila Pereira Dantas ◽  
Willames B S Martins ◽  
Fabíola Marques De Carvalho ◽  
Luiz Gonzaga Paula Almeida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Klebsiella Pneumoniae ◽  
High Mortality ◽  
Fatal Outcome ◽  
Mortality Rates ◽  
Sequence Type ◽  
Virulence Determinants ◽  
Klebsiella Pneumoniae Carbapenemase ◽  
Endemic Setting ◽  
Severity Scores

Abstract Background Carbapenemase-producing Klebsiella pneumoniae has become a global priority, not least in low- and middle-income countries. Here, we report the emergence and clinical impact of a novel Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-KP) sequence type (ST) 16 clone in a clonal complex (CC) 258–endemic setting. Methods In a teaching Brazilian hospital, a retrospective cohort of adult KPC-KP bloodstream infection (BSI) cases (January 2014 to December 2016) was established to study the molecular epidemiology and its impact on outcome (30-day all-cause mortality). KPC-KP isolates underwent multilocus sequence typing. Survival analysis between ST/CC groups and risk factors for fatal outcome (logistic regression) were evaluated. Representative isolates underwent whole-genome sequencing and had their virulence tested in a Galleria larvae model. Results One hundred sixty-five unique KPC-KP BSI cases were identified. CC258 was predominant (66%), followed by ST16 (12%). The overall 30-day mortality rate was 60%; in contrast, 95% of ST16 cases were fatal. Patients’ severity scores were high and baseline clinical variables were not statistically different across STs. In multivariate analysis, ST16 (odds ratio [OR], 21.4; 95% confidence interval [CI], 2.3–202.8; P = .008) and septic shock (OR, 11.9; 95% CI, 4.2–34.1; P < .001) were independent risk factors for fatal outcome. The ST16 clone carried up to 14 resistance genes, including blaKPC-2 in an IncFIBpQIL plasmid, KL51 capsule, and yersiniabactin virulence determinants. The ST16 clone was highly pathogenic in the larvae model. Conclusions Mortality rates were high in this KPC-KP BSI cohort, where CC258 is endemic. An emerging ST16 clone was associated with high mortality. Our results suggest that even in endemic settings, highly virulent clones can rapidly emerge demanding constant monitoring.

Regional outbreak of multidrug-resistant Klebsiella pneumoniae carbapenemase–producing Pseudomonas Aeruginosa

2021 ◽  
pp. 1-3
Author(s):  
Bekana K. Tadese ◽  
Anna Nutt ◽  
Ifrah Chaudhary ◽  
Charlene Offiong ◽  
Charles Darkoh
Keyword(s):  
United States ◽  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Epidemiologic Methods ◽  
The United States ◽  
Multidrug Resistant ◽  
Sequence Type ◽  
Klebsiella Pneumoniae Carbapenemase

Abstract Klebsiella pneumoniae carbapenemase-producing P. aeruginosa (KPC-CRPA) are rare in the United States. An outbreak of KPC-CRPA was investigated in Texas using molecular and epidemiologic methods and 17 cases of KPC-CRPA were identified. The isolates were genetically related and harbored the emerging P. aeruginosa multilocus sequence type 235, the first in the United States.

Transmission of novel Klebsiella pneumoniae carbapenemase-producing Escherichia coli sequence type 1193 among residents and caregivers in a community-based, residential care setting—Nevada, 2018

2020 ◽  
Vol 41 (11) ◽  
pp. 1341-1343
Author(s):  
Danica J. Gomes ◽  
Ana C. Bardossy ◽  
Lei Chen ◽  
Adrian Forero ◽  
Andrew Gorzalski ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Group Home ◽  
The United States ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Sequence Type ◽  
E Coli ◽  
Residential Group ◽  
Klebsiella Pneumoniae Carbapenemase

AbstractWe describe transmission of Klebsiella pneumoniae carbapenemase-producing Escherichia coli sequence type (ST) 1193 in a group home. E. coli ST1193 is an emerging multidrug-resistant clone not previously shown to carry carbapenemases in the United States. Our investigation illustrates the potential of residential group homes to amplify rare combinations of pathogens and resistance mechanisms.

scholarly journals Draft Genome Sequence of a Multidrug-Resistant Klebsiella pneumoniae Carbapenemase-Producing Acinetobacter baumannii Sequence Type 2 Isolate from Puerto Rico

2016 ◽  
Vol 4 (4) ◽  
Author(s):  
Teresa Martínez ◽  
Alexander J. Ropelewski ◽  
Ricardo González-Mendez ◽  
Guillermo J. Vázquez ◽  
Iraida E. Robledo
Keyword(s):  
Puerto Rico ◽  
Klebsiella Pneumoniae ◽  
Acinetobacter Baumannii ◽  
Genome Sequence ◽  
Draft Genome ◽  
Multidrug Resistant ◽  
Sequence Type ◽  
Draft Genome Sequence ◽  
Klebsiella Pneumoniae Carbapenemase

We report here the draft genome sequence of Acinetobacter baumannii strain M3AC14-8, sequence type 2 (ST2), carrying a chromosomally carried bla KPC-2 gene. The draft genome consists of a total length of 4.11 Mbp and a G+C content of 39.25%.

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