scholarly journals The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection

2017 ◽  
Vol 65 (12) ◽  
pp. 2042-2049 ◽  
Author(s):  
Kristine M Erlandson ◽  
Douglas Kitch ◽  
C William Wester ◽  
Robert C Kalayjian ◽  
Edgar Turner Overton ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Function ◽  
Virus Infection ◽  
Angiotensin Receptor Blocker ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Blocker Therapy ◽  
Immunodeficiency Virus ◽  
The Impact

scholarly journals The impact of antihypertensives on kidney disease

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 611 ◽  
Author(s):  
Diego F Marquez ◽  
Gema Ruiz-Hurtado ◽  
Luis Ruilope
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Angiotensin Receptor Blocker ◽  
Channel Blocker ◽  
Enzyme Inhibitor ◽  
New Drugs ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Positive Data ◽  
The Impact

Arterial hypertension and chronic kidney disease (CKD) are intimately related. The control of blood pressure (BP) levels is strongly recommended in patients with CKD in order to protect the kidney against the accompanying elevation in global cardiovascular (CV) risk. Actually, the goal BP in patients with CKD involves attaining values <140/90 mmHg except if albuminuria is present. In this case, it is often recommended to attain values <130/80 mmHg, although some guidelines still recommend <140/90 mmHg. Strict BP control to values of systolic BP around 120 mmHg was recently shown to be safe in CKD according to data from the SPRINT trial, albeit more data confirming this benefit are required. Usually, combination therapy initiated with an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEi) and commonly followed by the addition of a calcium channel blocker and a diuretic is needed. Further studies are required as well as new drugs in particular after the positive data obtained from new oral anti-diabetic drugs.

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