scholarly journals Long-term Use of Proton Pump Inhibitors Is Associated With Increased Microbial Product Translocation, Innate Immune Activation, and Reduced Immunologic Recovery in Patients With Chronic Human Immunodeficiency Virus-1 Infection

2017 ◽  
Vol 65 (10) ◽  
pp. 1638-1643 ◽  
Author(s):  
J A Serpa ◽  
A M Rueda ◽  
A Somasunderam ◽  
N S Utay ◽  
D Lewis ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Immune Activation ◽  
Innate Immune ◽  
Innate Immune Activation ◽  
Microbial Product ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Mortality in Severe Human Immunodeficiency Virus-Tuberculosis Associates With Innate Immune Activation and Dysfunction of Monocytes

2017 ◽  
Vol 65 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Saskia Janssen ◽  
Charlotte Schutz ◽  
Amy Ward ◽  
Elisa Nemes ◽  
Katalin A Wilkinson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Activation ◽  
Innate Immune ◽  
Innate Immune Activation ◽  
Immunodeficiency Virus

scholarly journals Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Sabine Kinloch-de Loes ◽  
Lucy Dorrell ◽  
Hongbing Yang ◽  
Gareth A. D. Hardy ◽  
Sabine Yerly ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Viral Reservoir ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune ◽  
Drug Free ◽  
Human Immunodeficiency Virus 1

Abstract Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4+/CD8+ T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.

Inhibition of long-term potentiation by interleukin-8: Implications for human immunodeficiency virus-1-associated dementia

2003 ◽  
Vol 71 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Huangui Xiong ◽  
Jeffery Boyle ◽  
Matthew Winkelbauer ◽  
Santhi Gorantla ◽  
Jialin Zheng ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Long Term Potentiation ◽  
Interleukin 8 ◽  
Term Potentiation ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Human Immunodeficiency Virus-1 Infection Interrupts Thymopoiesis and Multilineage Hematopoiesis In Vivo

Blood ◽  
1998 ◽  
Vol 91 (8) ◽  
pp. 2672-2678 ◽  
Author(s):  
Morgan Jenkins ◽  
Mary Beth Hanley ◽  
Mary Beth Moreno ◽  
Eric Wieder ◽  
Joseph M. McCune
Keyword(s):  
Human Immunodeficiency Virus ◽  
Progenitor Cells ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitors ◽  
Hematopoietic Progenitor ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

It is still uncertain whether multilineage hematopoietic progenitor cells are affected by human immunodeficiency virus-1 (HIV-1) infection in vivo. The SCID-hu Thy/Liv model is permissive of long-term multilineage human hematopoiesis, including T lymphopoiesis. This model was used to investigate the effects of HIV-1 infection on early hematopoietic progenitor function. We found that both lineage-restricted and multilineage hematopoietic progenitors were depleted from grafts infected with either a molecular clone or a primary isolate of HIV-1. Depletion of hematopoietic progenitors (including CD34+ cells, colony-forming units in methylcellulose, and long-term culture-initiating cells) occurred several days before the onset of thymocyte depletion, indicating that the subsequent rapid decline in thymocyte numbers was due at least in part to loss of thymocyte progenitors. HIV-1 proviral genomes were not detected at high frequency in hematopoietic cells earlier than the intrathymic T-progenitor cell stage, despite the depletion of such cells in infected grafts. Proviral genomes were also not detected in colonies derived from progenitor cells from infected grafts. These data demonstrate that HIV-1 infection interrupts both lineage-restricted and multilineage hematopoiesis in vivo and suggest that depletion of early hematopoietic progenitor cells occurs in the absence of direct viral infection.

scholarly journals Long-term Use of Proton Pump Inhibitors and Increased Immune Activation in Patients With Chronic HIV-1 Infection

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Jose Serpa ◽  
Adriana M. Rueda ◽  
Anoma Somasunderam ◽  
Netanya S. Utay ◽  
Dorothy Lewis ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Immune Activation ◽  
Hiv 1

Long Term Tolerability and Safety of Enfuvirtide for Human Immunodeficiency Virus 1-Infected Children

2004 ◽  
Vol 23 (8) ◽  
pp. 713-718 ◽  
Author(s):  
Joseph A. Church ◽  
Michael Hughes ◽  
Jie Chen ◽  
Paul Palumbo ◽  
Lynne M. Mofenson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immunodeficiency Virus ◽  
Term Tolerability ◽  
Human Immunodeficiency Virus 1
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