scholarly journals Applicability of Hepatitis C Virus RNA Viral Load Thresholds for 8-Week Treatments in Patients With Chronic Hepatitis C Virus Genotype 1 Infection

2016 ◽  
Vol 62 (10) ◽  
pp. 1228-1234 ◽  
Author(s):  
Johannes Vermehren ◽  
Benjamin Maasoumy ◽  
Raoel Maan ◽  
Gavin Cloherty ◽  
Caterina Berkowski ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genotype 1 ◽  
Hepatitis C Virus Rna ◽  
Virus Genotype ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

scholarly journals Delayed Viral Clearance after 6-Week Treatment with Peginterferon Plus Ribavirin in a Patient with Chronic Hepatitis C Virus Genotype 1b

2016 ◽  
Vol 10 (2) ◽  
pp. 417-422 ◽  
Author(s):  
Akira Sato ◽  
Toshiya Ishii ◽  
Kayo Adachi ◽  
Hideaki Takahashi ◽  
Fumiaki Sano ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Virus Rna ◽  
Virus Genotype ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment. We report a case of clearance of chronic hepatitis C virus infection following early discontinuation (at 6 weeks) of peginterferon plus ribavirin therapy, without negativity for hepatitis C virus RNA during the treatment period. The patient was a 76-year-old Japanese male infected with hepatitis C virus genotype 1b and TT of IL28B rs8099917. Hepatitis C virus RNA remained positive at persistently low levels for more than 2 months after the cessation of therapy and became negative at 7 months after the discontinuation of therapy. Spontaneous clearance of hepatitis C virus RNA can occur following antiviral failure in patients with persistently low viral loads, and virological follow-up is therefore necessary in chronic hepatitis C virus infection, even after antiviral failure.

Deferred treatment with a fixed‐dose combination of sofosbuvir‐velpatasvir for chronic hepatitis C virus genotype 1, 2, 4 and 6 infection

2019 ◽  
Vol 26 (10) ◽  
pp. 1229-1232
Author(s):  
Tarik Asselah ◽  
Stephen D. Shafran ◽  
Stefan Bourgeois ◽  
Ching‐Lung Lai ◽  
Philippe Mathurin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Fixed Dose ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Deferred Treatment ◽  
Chronic Hepatitis C Virus ◽  
Dose Combination

scholarly journals Safety and tolerability of ledipasvir/sofosbuvir with and without ribavirin in patients with chronic hepatitis C virus genotype 1 infection: Analysis of phase III ION trials

Hepatology ◽  
2015 ◽  
Vol 62 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Saleh A. Alqahtani ◽  
Nezam Afdhal ◽  
Stefan Zeuzem ◽  
Stuart C. Gordon ◽  
Alessandra Mangia ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Phase Iii ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Chronic Hepatitis C Virus
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