scholarly journals Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality

2014 ◽  
Vol 59 (8) ◽  
pp. 1066-1073 ◽  
Author(s):  
Zitta Barrella Harboe ◽  
Tine Dalby ◽  
Daniel M. Weinberger ◽  
Thomas Benfield ◽  
Kåre Mølbak ◽  
...  
Keyword(s):  
Invasive Pneumococcal Disease ◽  
Pneumococcal Disease ◽  
Disease Incidence ◽  
Incidence And Mortality ◽  
Conjugate Vaccination

scholarly journals Pneumococcal Pneumonia and Invasive Pneumococcal Disease in Those 65 and Older: Rates of Detection, Risk Factors, Vaccine Effectiveness, Hospitalisation and Mortality

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 13
Author(s):  
Roger E. Thomas
Keyword(s):  
Risk Factors ◽  
Nursing Home ◽  
Invasive Pneumococcal Disease ◽  
Disease Transmission ◽  
Pneumococcal Disease ◽  
Pneumococcal Pneumonia ◽  
Clinical Symptoms ◽  
Disease Incidence ◽  
Family Members ◽  
Vaccination Rates

Pneumococcal pneumonia (PP) and invasive pneumococcal disease (IPD) are important causes of morbidity and mortality in seniors worldwide. Incidence rates and serious outcomes worsen with increasing frailty, numbers of risk factors and decreasing immune competence with increasing age. Literature reviews in Medline and Embase were performed for pneumococcal disease incidence, risk factors, vaccination rates and effectiveness in the elderly. The introduction of protein-conjugated pneumoccal vaccines (PCV) for children markedly reduced IPD and PP in seniors, but serotypes not included in vaccines and with previously low levels increased. Pneumococcal polysaccharide (PPV23) vaccination does not change nasal and pharyngeal carriage rates. Pneumococcal and influenza vaccination rates in seniors are below guideline levels, especially in older seniors and nursing home staff. Pneumococcal and influenza carriage and vaccination rates of family members, nursing home health care workers and other contacts are unknown. National vaccination programmes are effective in increasing vaccination rates. Detection of IPD and PP initially depend on clinical symptoms and new chest X ray infiltrates and then varies according to the population and laboratory tests used. To understand how seniors and especially older seniors acquire PP and IPD data are needed on pneumococcal disease and carriage rates in family members, carers and contacts. Nursing homes need reconfiguring into small units with air ventilation externally from all rooms to minimise respiratory disease transmission and dedicated staff for each unit to minimise transmision of infectious diseaases.

Twelve years of pneumococcal conjugate vaccination in the Netherlands: Impact on incidence and clinical outcomes of invasive pneumococcal disease

Vaccine ◽  
2019 ◽  
Vol 37 (43) ◽  
pp. 6558-6565 ◽  
Author(s):  
Stefan M.T. Vestjens ◽  
Elisabeth A.M. Sanders ◽  
Bart J. Vlaminckx ◽  
Hester E. de Melker ◽  
Arie van der Ende ◽  
...  
Keyword(s):  
The Netherlands ◽  
Clinical Outcomes ◽  
Invasive Pneumococcal Disease ◽  
Pneumococcal Disease ◽  
Conjugate Vaccination

scholarly journals Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway

Vaccine ◽  
2008 ◽  
Vol 26 (26) ◽  
pp. 3277-3281 ◽  
Author(s):  
Didrik F. Vestrheim ◽  
Øistein Løvoll ◽  
Ingeborg S. Aaberge ◽  
Dominique A. Caugant ◽  
E. Arne Høiby ◽  
...  
Keyword(s):  
Invasive Pneumococcal Disease ◽  
Vaccination Programme ◽  
Pneumococcal Disease ◽  
Dose Schedule ◽  
Conjugate Vaccination
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