scholarly journals Added Benefit of Nucleic Acid Amplification Testing for the Diagnosis of Trichomonas vaginalis Among Men and Women Attending a Sexually Transmitted Diseases Clinic

2014 ◽  
Vol 59 (6) ◽  
pp. 834-841 ◽  
Author(s):  
C. A. Muzny ◽  
R. J. Blackburn ◽  
R. J. Sinsky ◽  
E. L. Austin ◽  
J. R. Schwebke
Keyword(s):  
Nucleic Acid ◽  
Sexually Transmitted Diseases ◽  
Trichomonas Vaginalis ◽  
Nucleic Acid Amplification ◽  
Men And Women ◽  
Sexually Transmitted ◽  
Nucleic Acid Amplification Testing ◽  
Added Benefit

scholarly journals Male Urethritis Caused by Trichomonas vaginalis

2021 ◽  
Vol 79 (1) ◽  
pp. 71-73
Author(s):  
Ângela Roda ◽  
João Borges-Costa
Keyword(s):  
Sexually Transmitted Infections ◽  
Sexually Transmitted Diseases ◽  
Trichomonas Vaginalis ◽  
Unusual Case ◽  
Parasitic Infection ◽  
Men And Women ◽  
Sexually Transmitted ◽  
Molecular Assays ◽  
The Past ◽  
The Impact

Trichomoniasis is one of the most common sexually transmitted infections worldwide. In women, Trichomonas vaginalis infection may present with vaginitis, cervicitis, or pelvic inflammatory disease, while in men it is mainly asymptomatic or causes mild and transient symptoms of urethritis, epididymitis, or prostatitis. In the past, little importance had been given to the impact of T. vaginalis infection on men’s health, since it was believed to be a self-limited condition without sequelae. However, there is growing evidence it is associated with more serious disorders in both men and women and efforts to diagnose and treat this parasitic infection have increased. Recent advances in testing for sexually transmitted diseases using multiplex molecular assays have increased diagnostic opportunities for T. vaginalis infection, especially in men, as detection of the parasite by traditional methods is much more challenging. We describe an unusual case of male urethritis caused by T. vaginalis observed in our consultation of Sexually Transmitted Infections.

scholarly journals Optimal Timing for Trichomonas vaginalis Test of Cure Using Nucleic Acid Amplification Testing

2019 ◽  
Vol 46 (5) ◽  
pp. 312-316 ◽  
Author(s):  
Megan Clare Craig-Kuhn ◽  
Charleigh Granade ◽  
Christina A. Muzny ◽  
Barbara Van Der Pol ◽  
Rebecca Lillis ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Trichomonas Vaginalis ◽  
Nucleic Acid Amplification ◽  
Optimal Timing ◽  
Nucleic Acid Amplification Testing

scholarly journals Use of Nucleic Acid Amplification Testing for Diagnosis of Extragenital Sexually Transmitted Infections

2017 ◽  
Vol 55 (9) ◽  
pp. 2801-2807 ◽  
Author(s):  
Lisa A. Cosentino ◽  
Claire S. Danby ◽  
Lorna K. Rabe ◽  
Ingrid Macio ◽  
Leslie A. Meyn ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Amplification ◽  
Content Type ◽  
Sexually Transmitted ◽  
Test Systems ◽  
Nucleic Acid Amplification Testing ◽  
Rectal Swabs ◽  
Confirmatory Tests ◽  
History Of ◽  
Higher Sensitivity

ABSTRACT Nucleic acid amplification testing (NAAT) is the preferred method to detect Chlamydia trachomatis and Neisseria gonorrhoeae , but no commercial tests are cleared by the U.S. Food and Drug Administration for use with extragenital swab samples. This study evaluated the performance of the Gen-Probe Aptima Combo2 assay (Aptima) and the Cepheid Xpert CT/NG assay (Xpert) to detect C. trachomatis and N. gonorrhoeae in rectal and pharyngeal samples from 224 men and 175 women reporting a history of anal receptive sexual intercourse. Discordant results between the NAATs were repeated using the assays APTIMA CT or APTIMA GC, which target alternate primers, as the confirmatory tests. C. trachomatis was detected from 59 rectal swabs and 8 pharyngeal samples, with 97.7% and 99.5% agreement between the two test systems, respectively. For C. trachomatis , Xpert was 95% sensitive (95% CI, 86 to 99%) and Aptima was 92% sensitive (95% CI, 81 to 97%) from rectal swabs, while both systems were 100% sensitive from pharyngeal samples. N. gonorrhoeae was detected from 30 rectal and 40 pharyngeal samples, with 99.5% and 97.5% agreement between the two test systems. The sensitivity of Xpert for N. gonorrhoeae from rectal swabs was 100% (95% CI, 88 to 100%) versus 93% (95% CI, 78 to 99%) for Aptima. From pharyngeal swab samples, Xpert was 98% sensitive (95% CI, 87 to 99.9%) versus 93% (95% CI, 80 to 98%) for Aptima. For C. trachomatis , neither system was >95% sensitive from the rectum, though both were >99.5% specific. For N. gonorrhoeae , Xpert had higher sensitivity than Aptima, but with more false positives from pharyngeal samples.

scholarly journals Clinical Evaluation of the Cepheid Xpert TV Assay for Detection of Trichomonas vaginalis with Prospectively Collected Specimens from Men and Women

2017 ◽  
Vol 56 (2) ◽  
Author(s):  
Jane R. Schwebke ◽  
C. A. Gaydos ◽  
T. Davis ◽  
J. Marrazzo ◽  
D. Furgerson ◽  
...  
Keyword(s):  
Trichomonas Vaginalis ◽  
Transmitted Disease ◽  
The United States ◽  
Nucleic Acid Amplification ◽  
Urine Samples ◽  
Broth Culture ◽  
Men And Women ◽  
Content Type ◽  
Sexually Transmitted ◽  
Diagnostic Sensitivity And Specificity

ABSTRACT Trichomoniasis is the most prevalent curable sexually transmitted disease (STD). It has been associated with preterm birth and the acquisition and transmission of HIV. Recently, nucleic acid amplification tests (NAAT) have been FDA cleared in the United States for detection of Trichomonas vaginalis in specimens from both women and men. This study reports the results of a multicenter study recently conducted using the Xpert TV (T. vaginalis) assay to test specimens from both men and women. On-demand results were available in as little as 40 min for positive specimens. A total of 1,867 women and 4,791 men were eligible for inclusion in the analysis. In women, the performance of the Xpert TV assay was compared to the patient infected status (PIS) derived from the results of InPouch TV broth culture and Aptima NAAT for T. vaginalis. The diagnostic sensitivities and specificities of the Xpert TV assay for the combined female specimens (urine samples, self-collected vaginal swabs, and endocervical swabs) ranged from 99.5 to 100% and 99.4 to 99.9%, respectively. For male urine samples, the diagnostic sensitivity and specificity were 97.2% and 99.9%, respectively, compared to PIS results derived from the results of broth culture for T. vaginalis and bidirectional gene sequencing of amplicons. Excellent performance characteristics were seen using both female and male specimens. The ease of using the Xpert TV assay should result in opportunities for enhanced screening for T. vaginalis in both men and women and, hopefully, improved control of this infection.

Trichomonas vaginalis Nucleic Acid Amplification Testing at an Urban HIV Clinic

2016 ◽  
Vol 43 (8) ◽  
pp. 483-488 ◽  
Author(s):  
Christina A. Muzny ◽  
Greer A. Burkholder ◽  
Karen R. Fry ◽  
Erika L. Austin ◽  
Jane R. Schwebke
Keyword(s):  
Nucleic Acid ◽  
Trichomonas Vaginalis ◽  
Nucleic Acid Amplification ◽  
Nucleic Acid Amplification Testing
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