scholarly journals Psychoeducation Improves Hepatitis C Virus Treatment During Opioid Substitution Therapy: A Controlled, Prospective Multicenter Trial

2013 ◽  
Vol 57 (suppl_2) ◽  
pp. S97-S104 ◽  
Author(s):  
Jens Reimer ◽  
Christiane Sybille Schmidt ◽  
Bernd Schulte ◽  
Dirk Gansefort ◽  
Jörg Gölz ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Multicenter Trial ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Prospective Multicenter Trial ◽  
Opioid Substitution

THU-167-Prevalence, linkage to care and treatment of hepatitis C virus in person who inject drugs under opioid substitution therapy in a Spanish area

2019 ◽  
Vol 70 (1) ◽  
pp. e235-e236
Author(s):  
Ylenia Pérez Castaño ◽  
Alexandra Gomez Garcia ◽  
Jose Manuel Chouza Pérez ◽  
Vanesa Sanz Largo ◽  
Sandra Arranz Diaz ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Linkage To Care ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Care And Treatment ◽  
Opioid Substitution

scholarly journals Efficacy of Direct-acting Antivirals for Chronic Hepatitis C Virus Infection in People Who Inject Drugs or Receive Opioid Substitution Therapy: A Systematic Review and Meta-analysis

2019 ◽  
Vol 70 (11) ◽  
pp. 2355-2365 ◽  
Author(s):  
Christiana Graf ◽  
Marcus M Mücke ◽  
Georg Dultz ◽  
Kai-Henrik Peiffer ◽  
Alica Kubesch ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Outcomes ◽  
People Who Inject Drugs ◽  
Discontinuation Rate ◽  
Direct Acting Antivirals ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Direct Acting ◽  
Opioid Substitution

Abstract Background Treatment uptake for hepatitis C virus (HCV) infection in people who inject drugs (PWID) and patients on opioid substitution therapy (OST) is still low despite treatment guidelines that advocate the use of direct-acting antivirals (DAAs) in all patients. Our aim in this review was to investigate treatment outcomes among PWID and patients on OST in comparison to control cohorts. Methods A search of Embase, Medline, PubMed, and Web of Science (from October 2010 to March 2018) was conducted to assess sustained virologic response (SVR), discontinuation rates, adherence, and HCV reinfection in PWID and patients on OST. Results We identified 11 primary articles and 12 conference abstracts comprising 1702 patients on OST, 538 PWID, and 19 723 patients who served as controls. Among patients on OST, the pooled SVR was 90% (95% confidence interval [CI], 87% to 93%) and pooled treatment discontinuation rate was 7% (95% CI, 4% to 11%). Similarly, the pooled SVR was 88% (95% CI, 80% to 93%) in PWID and the pooled treatment discontinuation rate was 9% (95% CI, 5% to 15%). There was no significant difference regarding pooled rates of SVR, adherence, and discontinuation between patients on OST and controls as well as between PWID and controls. HCV reinfection rates among patients on OST ranged from 0.0 to 12.5 per 100 person-years. Conclusions HCV treatment outcomes in PWID and patients on OST are similar to those in patients without a history of injecting drugs, supporting current guideline recommendations to treat HCV in these patient populations.

scholarly journals Epidemiology of hepatitis C virus infection among people receiving opioid substitution therapy (ECHO): study protocol

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Lisa Strada ◽  
Bernd Schulte ◽  
Christiane Sybille Schmidt ◽  
Uwe Verthein ◽  
Peter Cremer-Schaeffer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Study Protocol ◽  
Hepatitis C Virus Infection ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Opioid Substitution

Diagnosis of hepatitis c virus infection after entry to opioid substitution therapy

2015 ◽  
Vol 156 ◽  
pp. e122
Author(s):  
Sarah Larney ◽  
Jason Grebely ◽  
Michael Falster ◽  
Alexander Swart ◽  
Janaki Amin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Opioid Substitution

scholarly journals Uptake of hepatitis C virus screening and treatment in persons under opioid substitution therapy between 2008 and 2013 in Belgium

2021 ◽  
Vol 84 (2) ◽  
pp. 311-316
Author(s):  
D Busschots ◽  
A Arain ◽  
R Bielen ◽  
Ö.M. Koc ◽  
L Bruckers ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
The Other ◽  
Hcv Rna ◽  
Insurance Fund ◽  
Health Insurance Fund ◽  
Substitution Therapy ◽  
Opioid Substitution Therapy ◽  
Hcv Screening ◽  
Opioid Substitution

Background: Hepatitis C is a viral infection caused by the hepatitis C virus (HCV) with people who inject drugs as the main group at risk worldwide. Aim: This study investigated the differences in uptake for HCV screening and treatment between persons in opioid substitution therapy (OST) and the other members of the Christian Health Insurance Fund in Belgium. Methods: Invoice data were retrospectively collected from the Christian Health Insurance Fund, representing 42% of the healthcare users. Information on demographics, screening, diagnostic tests, treatment and disease progression was obtained from 2008 till 2013. All people in this study were aged 20-65 year. Persons in the OST group were identified as having at least one prescription reimbursed for methadone. This group was compared to the other members of the Insurance Fund not on OST (NOST). Results: The Insurance Fund registered 8,409 unique OST and 3,525,190 members in the general group. HCV RNA screening rate was higher in the OST group after correction for age and gender (4.3% vs. 0.2%). Ribavirin reimbursement, did not differ between the OST and NOST group screened for HCV RNA (16.9% vs. 14.4%), though the probability of having ribavirin reimbursed was smaller for females than for males. Procedures concerning disease progression were reimbursed less frequently in the HCV RNA screened OST group compared to the NOST group (0.3% vs. 1.2%). Conclusion: People on OST were screened more often for HCV RNA. However, the general uptake for HCV screening and treatment in both populations remained suboptimal.

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