scholarly journals Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

2013 ◽  
Vol 56 (11) ◽  
pp. 1530-1538 ◽  
Author(s):  
Suman Rijal ◽  
Bart Ostyn ◽  
Surendra Uranw ◽  
Keshav Rai ◽  
Narayan Raj Bhattarai ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Potential Role ◽  
Kala Azar ◽  
Parasite Drug Resistance

scholarly journals Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma Treatment

2018 ◽  
Vol 19 (12) ◽  
pp. 3834 ◽  
Author(s):  
Rohan Garje ◽  
Josiah An ◽  
Kevin Sanchez ◽  
Austin Greco ◽  
Jeffrey Stolwijk ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Clear Cell ◽  
Hypoxia Inducible Factors ◽  
Angiogenic Growth Factors ◽  
Cell Renal Cell Carcinoma

In the last two decades, the discovery of various pathways involved in renal cell carcinoma (RCC) has led to the development of biologically-driven targeted therapies. Hypoxia-inducible factors (HIFs), angiogenic growth factors, von Hippel–Lindau (VHL) gene mutations, and oncogenic microRNAs (miRNAs) play essential roles in the pathogenesis and drug resistance of clear cell renal cell carcinoma. These insights have led to the development of vascular endothelial growth factor (VEGF) inhibitors, Mechanistic target of rapamycin (mTOR) inhibitors, and immunotherapeutic agents, which have significantly improved the outcomes of patients with advanced RCC. HIF inhibitors will be a valuable asset in the growing therapeutic armamentarium of RCC. Various histone deacetylase (HDAC) inhibitors, selenium, and agents like PT2385 and PT2977 are being explored in various clinical trials as potential HIF inhibitors, to ameliorate the outcomes of RCC patients. In this article, we will review the current treatment options and highlight the potential role of selenium in the modulation of drug resistance biomarkers expressed in clear cell RCC (ccRCC) tumors.

scholarly journals Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

Oncotarget ◽  
2016 ◽  
Vol 7 (21) ◽  
pp. 30876-30891 ◽  
Author(s):  
Li Zhang ◽  
Ling Pan ◽  
Bing Xiang ◽  
Huanling Zhu ◽  
Yu Wu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Potential Role
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