scholarly journals Lyme Disease and Human Granulocytic Anaplasmosis Coinfection: Impact of Case Definition on Coinfection Rates and Illness Severity

2012 ◽  
Vol 56 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Harold W. Horowitz ◽  
Maria E. Aguero-Rosenfeld ◽  
Diane Holmgren ◽  
Donna McKenna ◽  
Ira Schwartz ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Illness Severity ◽  
Case Definition ◽  
Human Granulocytic Anaplasmosis ◽  
Granulocytic Anaplasmosis

scholarly journals The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America

2006 ◽  
Vol 43 (9) ◽  
pp. 1089-1134 ◽  
Author(s):  
Gary P. Wormser ◽  
Raymond J. Dattwyler ◽  
Eugene D. Shapiro ◽  
John J. Halperin ◽  
Allen C. Steere ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Infectious Diseases ◽  
Health Care Providers ◽  
Treatment Guidelines ◽  
Clinical Manifestations ◽  
Previous Treatment ◽  
Care Providers ◽  
Human Granulocytic Anaplasmosis ◽  
Treatment And Prevention ◽  
Granulocytic Anaplasmosis

Abstract Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1–14). The guidelines are intended for use by health care providers who care for patients who either have these infections or may be at risk for them. For each of these Ixodes tickborne infections, information is provided about prevention, epidemiology, clinical manifestations, diagnosis, and treatment. Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post–Lyme disease syndrome is proposed.

scholarly journals Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis

JAMA ◽  
2016 ◽  
Vol 315 (16) ◽  
pp. 1767 ◽  
Author(s):  
Edgar Sanchez ◽  
Edouard Vannier ◽  
Gary P. Wormser ◽  
Linden T. Hu
Keyword(s):  
Lyme Disease ◽  
Human Granulocytic Anaplasmosis ◽  
Treatment And Prevention ◽  
Granulocytic Anaplasmosis

scholarly journals Differences and Similarities between Culture-Confirmed Human Granulocytic Anaplasmosis and Early Lyme Disease

2013 ◽  
Vol 51 (3) ◽  
pp. 954-958 ◽  
Author(s):  
Gary P. Wormser ◽  
Maria E. Aguero-Rosenfeld ◽  
Mary E. Cox ◽  
John Nowakowski ◽  
Robert B. Nadelman ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Human Granulocytic Anaplasmosis ◽  
Granulocytic Anaplasmosis

scholarly journals CXCR2 Blockade Influences Anaplasma phagocytophilum Propagation but Not Histopathology in the Mouse Model of Human Granulocytic Anaplasmosis

2004 ◽  
Vol 11 (5) ◽  
pp. 963-968 ◽  
Author(s):  
Diana G. Scorpio ◽  
Mustafa Akkoyunlu ◽  
Erol Fikrig ◽  
J. Stephen Dumler
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Tissue Injury ◽  
Treated Group ◽  
Obligate Intracellular Bacterium ◽  
Human Granulocytic Anaplasmosis ◽  
Obligate Intracellular ◽  
Liver Histopathology ◽  
Granulocytic Anaplasmosis ◽  
Infected Cells ◽  
And Control

ABSTRACT Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils and causes human granulocytic anaplasmosis. Infection induces neutrophil secretion of interleukin-8 or murine homologs and perpetuates infection by recruiting susceptible neutrophils. We hypothesized that antibody blockade of CXCR2 would decrease A. phagocytophilum tissue load by interrupting neutrophil recruitment but would not influence murine hepatic pathology. C3H-scid mice were treated with CXCR2 antiserum or control prior to or on day 14 after infection. Quantitative PCR and immunohistochemistry for A. phagocytophilum were performed and severity of liver histopathology was ranked. Control mice had more infected cells in tissues than the anti-CXCR2-treated group. The histopathological rank was not different between treated and control animals. Infected cells of control mice clustered in tissue more than in treated mice. The results support the hypothesis of bacterial propagation through chemokine induction and confirm that tissue injury is unrelated to A. phagocytophilum tissue load.

scholarly journals Human Granulocytic Anaplasmosis Acquired in Scotland, 2013

2014 ◽  
Vol 20 (6) ◽  
pp. 1079-1081 ◽  
Author(s):  
Peter Hagedorn ◽  
Maren Imhoff ◽  
Christian Fischer ◽  
Cristina Domingo ◽  
Matthias Niedrig
Keyword(s):  
Human Granulocytic Anaplasmosis ◽  
Granulocytic Anaplasmosis
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