scholarly journals  -Glucan Antigenemia Assay for the Diagnosis of Invasive Fungal Infections in Patients With Hematological Malignancies: A Systematic Review and Meta-Analysis of Cohort Studies From the Third European Conference on Infections in Leukemia (ECIL-3)

2011 ◽  
Vol 54 (5) ◽  
pp. 633-643 ◽  
Author(s):  
F. Lamoth ◽  
M. Cruciani ◽  
C. Mengoli ◽  
E. Castagnola ◽  
O. Lortholary ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Hematological Malignancies ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Invasive Fungal Infections ◽  
European Conference ◽  
The Third ◽  
Antigenemia Assay

Micronutrient Intake and Risk of Hematological Malignancies in Adults: A Systematic Review and Meta-analysis of Cohort Studies

2018 ◽  
Vol 70 (6) ◽  
pp. 821-839 ◽  
Author(s):  
Theodora Psaltopoulou ◽  
Ioannis Ntanasis-Stathopoulos ◽  
Diamantis I. Tsilimigras ◽  
Ioannis-Georgios Tzanninis ◽  
Maria Gavriatopoulou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Hematological Malignancies ◽  
Meta Analysis ◽  
Micronutrient Intake

Risk factors of invasive fungal infections in liver transplant recipients: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Pakpoom Phoompoung ◽  
Sabina Herrera ◽  
Armelle Pérez Cortés Villalobos ◽  
Farid Foroutan ◽  
Ani Orchanian‐Cheff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Liver Transplant ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Invasive Fungal Infections ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Anthropometric characteristics, physical activity and risk of hematological malignancies: A systematic review and meta‐analysis of cohort studies

2019 ◽  
Vol 145 (2) ◽  
pp. 347-359 ◽  
Author(s):  
Theodora Psaltopoulou ◽  
Theodoros N. Sergentanis ◽  
Ioannis Ntanasis‐Stathopoulos ◽  
Ioannis‐Georgios Tzanninis ◽  
Elena Riza ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cohort Studies ◽  
Hematological Malignancies ◽  
Meta Analysis ◽  
Anthropometric Characteristics

Risk Factors of Invasive Fungal Infections in Heart and Lung Transplantation: Systematic Review and Meta-Analysis

2020 ◽  
Vol 39 (4) ◽  
pp. S485
Author(s):  
P. Phoompoung ◽  
A. Perez Cortes Villalobos ◽  
S. Jain ◽  
F. Faroutan ◽  
A. Orchanian-Cheff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Lung Transplantation ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Invasive Fungal Infections

scholarly journals Coinfections with Bacteria, Fungi, and Respiratory Viruses in Patients with SARS-CoV-2: A Systematic Review and Meta-Analysis

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 809
Author(s):  
Saad Alhumaid ◽  
Abbas Al Mutair ◽  
Zainab Al Alawi ◽  
Abeer M. Alshawi ◽  
Salamah A. Alomran ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Visual Inspection ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Case Series ◽  
Respiratory Viruses ◽  
Effect Sizes ◽  
P Values ◽  
Funnel Plots

Background: Coinfection with bacteria, fungi, and respiratory viruses in SARS-CoV-2 is of particular importance due to the possibility of increased morbidity and mortality. In this meta-analysis, we calculated the prevalence of such coinfections. Methods: Electronic databases were searched from 1 December 2019 to 31 March 2021. Effect sizes of prevalence were pooled with 95% confidence intervals (CIs). To minimize heterogeneity, we performed sub-group analyses. Results: Of the 6189 papers that were identified, 72 articles were included in the systematic review (40 case series and 32 cohort studies) and 68 articles (38 case series and 30 cohort studies) were included in the meta-analysis. Of the 31,953 SARS-CoV-2 patients included in the meta-analysis, the overall pooled proportion who had a laboratory-confirmed bacterial infection was 15.9% (95% CI 13.6–18.2, n = 1940, 49 studies, I2 = 99%, p < 0.00001), while 3.7% (95% CI 2.6–4.8, n = 177, 16 studies, I2 = 93%, p < 0.00001) had fungal infections and 6.6% (95% CI 5.5–7.6, n = 737, 44 studies, I2 = 96%, p < 0.00001) had other respiratory viruses. SARS-CoV-2 patients in the ICU had higher co-infections compared to ICU and non-ICU patients as follows: bacterial (22.2%, 95% CI 16.1–28.4, I2 = 88% versus 14.8%, 95% CI 12.4–17.3, I2 = 99%), and fungal (9.6%, 95% CI 6.8–12.4, I2 = 74% versus 2.7%, 95% CI 0.0–3.8, I2 = 95%); however, there was an identical other respiratory viral co-infection proportion between all SARS-CoV-2 patients [(ICU and non-ICU) and the ICU only] (6.6%, 95% CI 0.0–11.3, I2 = 58% versus 6.6%, 95% CI 5.5–7.7, I2 = 96%). Funnel plots for possible publication bias for the pooled effect sizes of the prevalence of coinfections was asymmetrical on visual inspection, and Egger’s tests confirmed asymmetry (p values < 0.05). Conclusion: Bacterial co-infection is relatively high in hospitalized patients with SARS-CoV-2, with little evidence of S. aureus playing a major role. Knowledge of the prevalence and type of co-infections in SARS-CoV-2 patients may have diagnostic and management implications.

Comparative accuracy of 1,3 beta-D glucan and galactomannan for diagnosis of invasive fungal infections in pediatric patients: a systematic review with meta-analysis

2020 ◽  
Author(s):  
Shreya Singh ◽  
Manvi Singh ◽  
Nipun Verma ◽  
Minakshi Sharma ◽  
Pranita Pradhan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pediatric Patients ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Invasive Fungal Infections ◽  
Cochrane Library ◽  
Operating Characteristics ◽  
Oncology Patients ◽  
Specificity And Sensitivity ◽  
Sensitivity Specificity

Abstract Invasive fungal infections (IFI) cause considerable morbidity and mortality in pediatric patients. Serum biomarkers such as 1,3-beta-D glucan (BDG) and galactomannan (GM) have been evaluated for the IFI diagnosis. However, most evidence regarding their utility is derived from studies in adult oncology patients. This systematic review aimed to compare the diagnostic accuracy of BDG and GM individually or in combination for diagnosing IFI in pediatric patients. PubMed, CINAHL, Embase, and Cochrane Library were searched until March 2019 for diagnostic studies evaluating both serum GM and BDG for diagnosing pediatric IFI. The pooled diagnostic odds ratio (DOR), specificity and sensitivity were computed. Receiver operating characteristics (ROC) curve and area under the curve (AUC) were used for summarizing overall assay performance. Six studies were included in the meta-analysis. The summary estimates of sensitivity, specificity, pooled DOR, AUC of the GM assay for proven or probable IFI were 0.74, 0.76, 13.25, and 0.845. The summary estimates of sensitivity, specificity, pooled DOR, AUC of the BDG assay were 0.70, 0.69, 4.3, and 0.722. The combined predictive ability of both tests was reported in two studies (sensitivity: 0.67, specificity: 0.877). Four studies were performed in hematology-oncology patients, while two were retrospective studies from pediatric intensive care units (ICUs). In the subgroup of hematology-oncology patients, DOR of BDG remained similar at 4.25 but increased to 40.28 for GM. We conclude that GM and BDG have a modest performance for identifying IFI in pediatric patients. GM has a better accuracy over BDG. Combining both improves the specificity at the cost of sensitivity.

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