scholarly journals A Comparison of 3 Regimens to Prevent Nevirapine Resistance Mutations in HIV-Infected Pregnant Women Receiving a Single Intrapartum Dose of Nevirapine

2011 ◽  
Vol 54 (2) ◽  
pp. 285-293 ◽  
Author(s):  
R. B. Van Dyke ◽  
N. Ngo-Giang-Huong ◽  
D. E. Shapiro ◽  
L. Frenkel ◽  
P. Britto ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Resistance Mutations ◽  
Nevirapine Resistance

scholarly journals Analysis of Nevirapine Resistance Mutations in Cloned HIV Type 1 Variants from HIV-Infected Ugandan Infants Using a Single-Step Amplification-Sequencing Method (AmpliSeq)

2008 ◽  
Vol 24 (9) ◽  
pp. 1209-1213 ◽  
Author(s):  
William Ian Towler ◽  
Jessica D. Church ◽  
James R. Eshleman ◽  
Mary Glenn Fowler ◽  
Laura A. Guay ◽  
...  
Keyword(s):  
Single Step ◽  
Resistance Mutations ◽  
Sequencing Method ◽  
Hiv Type 1 ◽  
Nevirapine Resistance

Genetic Linkage of Nevirapine Resistance Mutations in HIV Type 1 Seven Days after Single-Dose Nevirapine

2005 ◽  
Vol 21 (4) ◽  
pp. 319-324 ◽  
Author(s):  
Dana Jones ◽  
Neil Parkin ◽  
Sarah E. Hudelson ◽  
Laura A. Guay ◽  
Philippa Musoke ◽  
...  
Keyword(s):  
Single Dose ◽  
Genetic Linkage ◽  
Resistance Mutations ◽  
Single Dose Nevirapine ◽  
Hiv Type 1 ◽  
Nevirapine Resistance

Moderate Prevalence of Transmitted Drug Resistance Mutations Among Antiretroviral-Naive HIV-Infected Pregnant Women in Rio de Janeiro, Brazil

2013 ◽  
Vol 29 (4) ◽  
pp. 681-686 ◽  
Author(s):  
José H. Pilotto ◽  
Beatriz Grinsztejn ◽  
Valdilea G. Veloso ◽  
Luciane S. Velasque ◽  
Ruth K. Friedman ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pregnant Women ◽  
Rio De Janeiro ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations

scholarly journals Etravirine resistance mutations in HIV-infected pregnant women

HIV Medicine ◽  
2013 ◽  
Vol 14 (2) ◽  
pp. 125-126 ◽  
Author(s):  
DM Cecchini ◽  
I Zapiola ◽  
S Fernandez Giuliano ◽  
MG Martinez ◽  
CG Rodriguez ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Resistance Mutations

HIV-1 pol Gene Polymorphism and Antiretroviral Resistance Mutations in Drug-Naive Pregnant Women in Yaoundé, Cameroon

2006 ◽  
Vol 42 (2) ◽  
pp. 256-258 ◽  
Author(s):  
Aurélia Vessière ◽  
Eric Nerrienet ◽  
Anfumbom Kfutwah ◽  
Elisabeth Menu ◽  
Mathurin Tejiokem ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Pregnant Women ◽  
Resistance Mutations ◽  
Antiretroviral Resistance ◽  
Drug Naïve ◽  
Hiv 1

Selection of resistance mutations in pregnant women receiving zidovudine and lamivudine to prevent HIV perinatal transmission

AIDS ◽  
2003 ◽  
Vol 17 (10) ◽  
pp. 1570-1572 ◽  
Author(s):  
Marina Giuliano ◽  
Lucia Palmisano ◽  
Clementina M Galluzzo ◽  
Roberta Amici ◽  
Elena Germinario ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Perinatal Transmission ◽  
Resistance Mutations ◽  
Selection Of ◽  
Selection Of Resistance

scholarly journals Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina

2021 ◽  
Author(s):  
Diego Cecchini ◽  
◽  
Javier Sfalcin ◽  
Inés Zapiola ◽  
Alan Gómez ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pregnant Women ◽  
Lower Risk ◽  
Perinatal Transmission ◽  
Viral Population ◽  
Transmitted Drug Resistance ◽  
Mutational Load ◽  
Resistance Mutations ◽  
Minority Variants ◽  
Hiv 1

Objective. Argentina has reported high levels of transmitted drug resistance (TDR), in HIV-infected pregnant women by population sequencing. We aimed to describe, in patients with TDR, the percentage of quasispecies harboring resistance mutations (RAMs) and mutational load (ML). Patients and Methods. Retrospective study in a cohort of 40 naïve HIV-infected pregnant women, whose pretreatment samples had been genotyped by TRUGENE (period 2008-2014). Samples were re-sequenced with Ultra-deep Sequencing and ML was calculated considering baseline HIV-1 RNA load multiplied by the frequency of quasispecies harboring RAMs. Results. TDR for NNRTIs, NRTIs and PIs was 17.5% (n=7 patients), 10% (n=4), 12.5% (n=5) respectively. Predominant NNRTI RAMs were K103N (n=4; 10%) and G190A/E/S (n=3; 7.5%). For NNRTIs, 78% of RAMs were present in >93.5% of viral population and ML was >1000 copies/mL (c/mL) for 89%, with a median (IQR) of 8330 c/ml (7738-29796). The following NRTI RAMs were described (per patient: % of quasispecies, ML): T215I (99.7%, 11014 c/ml); D67G (1.28%, 502 c/mL); M41L (79.8%, 88578 c/mL) and M184I (1.02%, 173 c/mL). Most frequent PI-RAMs were I85V, M46I, I50V and L90M (n=2, 5% each). For PIs, quasispecies with RAMs were <2.3% of viral population and ML was <350 c/mL for 77.8% of them. Conclusion. NNRTI-RAMs are predominant within the viral population, usually exceeding the threshold of 1000 c/mL, indicating potential higher risk of perinatal transmission. Conversely, PI mutations appear mostly as minority variants, with potential lower risk of transmission. Among NRTI, quasispecies harboring RAMs and ML values were variable.

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