scholarly journals Effectiveness of an Adjuvanted Monovalent Vaccine Against the 2009 Pandemic Strain of Influenza A(H1N1)v in Stockholm County, Sweden

2011 ◽  
Vol 52 (10) ◽  
pp. 1203-1211 ◽  
Author(s):  
A. Ortqvist ◽  
I. Berggren ◽  
M. Insulander ◽  
B. de Jong ◽  
B. Svenungsson
Keyword(s):  
Influenza A ◽  
Stockholm County ◽  
Pandemic Strain ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

Effectiveness of the pandemic influenza A/H1N1 2009 monovalent vaccine in Korea

Vaccine ◽  
2011 ◽  
Vol 29 (7) ◽  
pp. 1395-1398 ◽  
Author(s):  
Joon Young Song ◽  
Hee Jin Cheong ◽  
Jung Yeon Heo ◽  
Ji Yun Noh ◽  
Won Suk Choi ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among Japanese pregnant women: A prospective observational study assessing antibody efficacy

Vaccine ◽  
2012 ◽  
Vol 30 (52) ◽  
pp. 7630-7636 ◽  
Author(s):  
Wakaba Fukushima ◽  
Satoko Ohfuji ◽  
Masaaki Deguchi ◽  
Kazume Kawabata ◽  
Hideaki Hatayama ◽  
...  
Keyword(s):  
Observational Study ◽  
Pregnant Women ◽  
Influenza A ◽  
Prospective Observational Study ◽  
Monovalent Vaccine ◽  
Influenza A H1n1 ◽  
Japanese Pregnant Women

scholarly journals Seroprevalence of influenza A H1N1 and seroconversion of mothers and infants induced by a single dose of monovalent vaccine

2013 ◽  
Vol 52 (3) ◽  
pp. 356-359 ◽  
Author(s):  
Anne Chao ◽  
Yhu-Chering Huang ◽  
Yao-Lung Chang ◽  
Tzu-Hao Wang ◽  
Shuenn-Dyh Chang ◽  
...  
Keyword(s):  
Single Dose ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

Antibody Response to Inactivated Influenza A (H1N1) 2009 Monovalent Vaccine in Patients With and Without HIV

2011 ◽  
Vol 58 (3) ◽  
pp. e99-e102 ◽  
Author(s):  
Ceres T. Tiu ◽  
Yu Shia Lin ◽  
Murali Pagala ◽  
Monica Ghitan ◽  
John J. Treanor ◽  
...  
Keyword(s):  
Antibody Response ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

Reduced immune response to influenza A (H1N1) 2009 monovalent vaccine in HIV-infected Japanese subjects

Vaccine ◽  
2011 ◽  
Vol 29 (34) ◽  
pp. 5694-5698 ◽  
Author(s):  
Naoki Yanagisawa ◽  
Kazuhiro Maeda ◽  
Atsushi Ajisawa ◽  
Akifumi Imamura ◽  
Akihiko Suganuma ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1 ◽  
Japanese Subjects

scholarly journals Influenza A H1N1 Pandemic Strain Evolution – Divergence and the Potential for Antigenic Drift Variants

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93632 ◽  
Author(s):  
Eili Y. Klein ◽  
Adrian W. R. Serohijos ◽  
Jeong-Mo Choi ◽  
Eugene I. Shakhnovich ◽  
Andrew Pekosz
Keyword(s):  
Influenza A ◽  
Antigenic Drift ◽  
H1n1 Pandemic ◽  
Pandemic Strain ◽  
Strain Evolution ◽  
Influenza A H1n1

scholarly journals P2-420 Immunogenicity of pandemic influenza A (H1N1) monovalent vaccine among immunosuppressed hematooncology patients

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A337-A338
Author(s):  
S. Ide ◽  
Y. Imamura ◽  
Y. Ide ◽  
C. Tsutsumi ◽  
Y. Ifuku ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

Effects of immunizing school children with 2009 influenza A (H1N1) monovalent vaccine on absenteeism among students and teachers in Maine

Vaccine ◽  
2012 ◽  
Vol 30 (32) ◽  
pp. 4835-4841 ◽  
Author(s):  
Samuel B. Graitcer ◽  
Nancy L. Dube ◽  
Ricardo Basurto-Davila ◽  
Peter F. Smith ◽  
Jill Ferdinands ◽  
...  
Keyword(s):  
School Children ◽  
Influenza A ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

scholarly journals Adamantan derivatives capable of inhibiting the reproduction of a Rimantadine resistant strain of influenza A(H1N1)pdm09 virus (Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae)

2020 ◽  
Vol 65 (1) ◽  
pp. 16-20 ◽  
Author(s):  
T. M. Garaev ◽  
A. I. Odnovorov ◽  
E. S. Kirillova ◽  
E. I. Burtseva ◽  
M. P. Finogenova ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Resistant Strain ◽  
Influenza A ◽  
Inhibitory Concentration ◽  
Influenza Viruses ◽  
Synthesis Methods ◽  
Synthetic Compounds ◽  
Pandemic Strain ◽  
Influenza A H1n1

Introduction. Adamantanthane-type drugs such as rimantadine and amantadine have long been used to treat diseases caused by influenza A virus. However, as a result of the mutations, influenza viruses have become resistant to aminoadamantans. The target for these drugs was the protein channel M2. Influenza A virus M2 viroporin in the protein shell forms fairly specific ion channels with a diameter of about 11 Å, specializing in transporting protons inside the viral particle (virion). Restoration of the antiviral properties of adamantanthane-type drugs consists in the selection of advanced functional groups bound by the carbocycle to find new sites of binding to the protein target M2.The рurpose of the study is to identify the antiviral properties of new adamantanum derivatives to the pandemic strain of influenza A virus in vitro.Material and methods. Compounds of aminoadamantans with amino acids and other organic molecules were obtained by classical peptide synthesis methods. The structure of the compound was tested by means of physical and chemical methods. Antiviral properties of synthetic compounds were studied in vitro on monolayer MDCK cells infected with pandemic strain of influenza A/California/07/2009 virus in two schemes of administration of investigated compounds and virus.Results. The reference strain of the influenza virus A/California/07/2009(H1N1) was sensitive to the compounds under test in varying degrees. The antiviral activity of the compounds was expressed in a 50% inhibitory concentration (IС50) ranging from 0.5 to 2.5 мкM, which is generally a good indicator for the Rimantadine/Amantadine resistant strain.Discussion. The values of the IС50 for compounds introduced two hours before contact with the virus were slightly higher than those for single-moment introduction of the substance and virus. The effect of increasing the inhibitory concentration in the prophylactic scheme of compounds was valid for all compounds of the experiment.Conclusion. The presented synthetic compounds are active against the variant of influenza A virus resistant to Rimantadine and Amantadine preparations. The obtained compounds can be used as model structures for creation of a new drug of direct action against advanced strains of influenza A virus.

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