scholarly journals Relationship between Immunity to Borrelia burgdorferi Outer-surface Protein A (OspA) and Lyme Arthritis

2011 ◽  
Vol 52 (suppl_3) ◽  
pp. s259-s265 ◽  
Author(s):  
Allen C. Steere ◽  
Elise E. Drouin ◽  
Lisa J. Glickstein
Keyword(s):  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Lyme Arthritis ◽  
Outer Surface Protein A ◽  
Outer Surface Protein

scholarly journals Occurrence of Severe Destructive Lyme Arthritis in Hamsters Vaccinated with Outer Surface Protein A and Challenged with Borrelia burgdorferi

2000 ◽  
Vol 68 (2) ◽  
pp. 658-663 ◽  
Author(s):  
Cindy L. Croke ◽  
Erik L. Munson ◽  
Steven D. Lovrich ◽  
John A. Christopherson ◽  
Monica C. Remington ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Aluminum Hydroxide ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Major Complication ◽  
Sensu Stricto ◽  
Lyme Arthritis ◽  
Outer Surface Protein A ◽  
Outer Surface Protein

ABSTRACT Arthritis is a frequent and major complication of infection withBorrelia burgdorferi sensu stricto. The antigens responsible for the induction of arthritis are unknown. Here we provide direct evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis. Hamsters were vaccinated with 30, 60, or 120 μg of recombinant OspA (rOspA) in aluminum hydroxide and challenged with B. burgdorferi sensu stricto isolate 297 or C-1-11. Swelling of the hind paws was detected in 100, 100, and 50% of hamsters vaccinated with 30, 60, or 120 μg of rOspA, respectively. In addition, arthritis developed in 57% of hamsters vaccinated with a canine rOspA vaccine after infection with B. burgdorferisensu stricto. When the canine rOspA vaccine was combined with aluminum hydroxide, all vaccinated hamsters developed arthritis after challenge with B. burgdorferi sensu stricto. Histopathologic examination confirmed the development of severe destructive arthritis in rOspA-vaccinated hamsters challenged with B. burgdorferisensu stricto. These findings suggest that rOspA vaccines should be modified to eliminate epitopes of OspA responsible for the induction of arthritis. Our results are important because an rOspA vaccine in aluminum hydroxide was approved by the Food and Drug Administration for use in humans.

Multiple cross-reactive seif-ligands for Borrelia burgdorferi outer surface protein A (OspA)-specific HLA-DR4-restricted T Cells

1999 ◽  
Vol 289 (5-7) ◽  
pp. 673 ◽  
Author(s):  
Bert Maier ◽  
Marc Molinger ◽  
Andrew P. Cope ◽  
Lars Fugger ◽  
Jens Schneider-Mergener ◽  
...  
Keyword(s):  
T Cells ◽  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Outer Surface Protein A ◽  
Outer Surface Protein ◽  
Multiple Cross

Immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against Lyme disease in children

1999 ◽  
Vol 135 (5) ◽  
pp. 575-579 ◽  
Author(s):  
Henry M. Feder ◽  
Jeri Beran ◽  
Christian Van Hoecke ◽  
Betsy Abraham ◽  
Norbert De Clercq ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Outer Surface Protein A ◽  
Outer Surface Protein
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