scholarly journals Trivalent Inactivated Influenza Vaccine in African Adults Infected With Human Immunodeficient Virus: Double Blind, Randomized Clinical Trial of Efficacy, Immunogenicity, and Safety

2011 ◽  
Vol 52 (1) ◽  
pp. 128-137 ◽  
Author(s):  
S. A. Madhi ◽  
M. Maskew ◽  
A. Koen ◽  
L. Kuwanda ◽  
T. G. Besselaar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Influenza Vaccine ◽  
Randomized Clinical Trial ◽  
Double Blind ◽  
Human Immunodeficient Virus

scholarly journals DNA Priming for Seasonal Influenza Vaccine: A Phase 1b Double-Blind Randomized Clinical Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125914 ◽  
Author(s):  
Julie E. Ledgerwood ◽  
Abbie R. Bellamy ◽  
Robert Belshe ◽  
David I. Bernstein ◽  
Srilatha Edupuganti ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Influenza Vaccine ◽  
Randomized Clinical Trial ◽  
Seasonal Influenza ◽  
Double Blind ◽  
Seasonal Influenza Vaccine ◽  
Phase 1B

scholarly journals REACTOGENICITY, SAFETY AND IMMUNOGENICITY OF DOMESTIC FLU-M INACTIVATED SPLIT INFLUENZA VACCINE FOR THE IMMUNIZATION OF ADULTS AGED BETWEEN 18 AND 60

2018 ◽  
pp. 31-37
Author(s):  
I. V. Feldblyum ◽  
K. A. Subbotina ◽  
S. D. Novgorodova ◽  
G. M. Ignatev ◽  
M. Kh. Alyeva ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Influenza Vaccine ◽  
Randomized Clinical Trial ◽  
Russian Federation ◽  
Safety Profile ◽  
Double Blind ◽  
Influenza Prevention ◽  
The Russian Federation ◽  
Research Institute

Aim. The research was aimed at evaluating the reactogenicity, safety and immunogenicity of Flu-M inactivated split influenza vaccine. Materials and methods. The reactogenicity, safety and immunogenicity of the drug were studied in the course of a multicenter, double blind, comparative, randomized clinical trial of immunized volunteers aged between 18 and 60 (comparator - Vaxigrip inactivated split vaccine for influenza prevention). Results. Domestic Flu-M inactivated split influenza vaccine manufactured by St. Petersburg Research Institute of Vaccines and Sera features favorable tolerability, high safety profile and adequate immunogenicity which is consistent with that of Vaxigrip influenza vaccine. Conclusion. Flu-M inactivated split influenza vaccine manufactured by St. Petersburg Research Institute of Vaccines and Sera can be recommended for authorization in the Russian Federation for the purpose of specific prophylaxis of influenza for adults aged between 18 and 60.

Comparing Intradermal Sterile Water with Intravenous Morphine in Reducing Pain in Patients with Renal Colic: A Double-Blind Randomized Clinical Trial

2020 ◽  
Vol 15 (1) ◽  
pp. 76-82
Author(s):  
Javad Mozafari ◽  
Mohammadreza Maleki Verki ◽  
Fatemeh Tirandaz ◽  
Reza Mahjouri
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Therapeutic Effects ◽  
Sterile Water ◽  
Morphine Group ◽  
Double Blind ◽  
Water Group ◽  
Intravenous Morphine ◽  
Painful Area

Objective: The present study was conducted to investigate the effect of intradermal administration of sterile water compared to intravenous morphine on patients with renal colic. Methods: This double-blind, randomized clinical trial study was conducted in 2017 to compare the therapeutic effects of intradermal sterile water with those of intravenous morphine on patients with renal colic presenting to the emergency departments (ED) of Imam Khomeini and Golestan Hospitals in Ahvaz, Iran. The first group received 0.5 ml of intradermal sterile water, and the second group 0.1mg/kg of intravenous morphine plus 0.5 ml of intradermal sterile water in the most painful area or the center of the painful area in the flank. The pain severity was measured using a visual analogue scale (VAS), and the medication side-effects were recorded at the beginning of the study and minutes 15, 30,45 and 60. Result: A total of 94 patients were studied in two groups. The mean severity of pain was 2.97 ± 1.51 in the sterile water group and 2.34 ± 1.89 in the morphine group at minute 30 (P=0.042), 2.58 ± 1.43 in the sterile water group and 1 ± 1.23 in the morphine group at minute 45 (p<0.001), and 1.89 ± 1.7 in the sterile water group and 0.52 ± 0.79 in the morphine group at minute 60 (p<0.001). Conclusion: Morphine reduces pain faster and more effectively than intradermal sterile water; nevertheless, treatment with intradermal sterile water can be used as an appropriate surrogate or adjunct therapy for pain control, particularly in special patients or in case of medication scarcity.

Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial

2021 ◽  
Author(s):  
José González‐Serrano ◽  
Rosa María López‐Pintor ◽  
Julia Serrano ◽  
Jesús Torres ◽  
Gonzalo Hernández ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Short Term ◽  
Double Blind ◽  
Propolis Extract ◽  
Term Efficacy
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