Hepatic steatosis associated with exposure to elvitegravir and raltegravir

2021 ◽  
Author(s):  
Ditte Marie Kirkegaard-Klitbo ◽  
Magda Teresa Thomsen ◽  
Marco Gelpi ◽  
Flemming Bendtsen ◽  
Susanne Dam Nielsen ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatic Steatosis ◽  
Alcohol Intake ◽  
Cumulative Exposure ◽  
People Living With Hiv ◽  
Causal Association ◽  
Excessive Alcohol ◽  
Prospective Trials ◽  
Living With Hiv ◽  
Excessive Alcohol Intake

Abstract Moderate-to-severe hepatic steatosis in people living with HIV without viral hepatitis or excessive alcohol intake was associated with cumulative exposure to stavudine, elvitegravir and raltegravir. Prospective trials are required to establish a causal association.

scholarly journals Inflammation in Primary and Metastatic Liver Tumorigenesis–Under the Influence of Alcohol and High-Fat Diets

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 933 ◽  
Author(s):  
Lauren S. Strathearn ◽  
Afanasii I. Stepanov ◽  
Joan Font-Burgada
Keyword(s):  
Liver Disease ◽  
Liver Metastasis ◽  
Alcohol Intake ◽  
Cancer Type ◽  
High Fat ◽  
High Fat Diets ◽  
Excessive Alcohol ◽  
Fat Diets ◽  
Metastatic Liver ◽  
Excessive Alcohol Intake

The liver plays an outsized role in oncology. Liver tumors are one of the most frequently found tumors in cancer patients and these arise from either primary or metastatic disease. Hepatocellular carcinoma (HCC), the most prevalent form of primary liver cancer and the 6th most common cancer type overall, is expected to become the 3rd leading cause of cancer mortality in the US by the year 2030. The liver is also the most common site of distant metastasis from solid tumors. For instance, colorectal cancer (CRC) metastasizes to the liver in two-thirds of cases, and CRC liver metastasis is the leading cause of mortality in these patients. The interplay between inflammation and cancer is unmistakably evident in the liver. In nearly every case, HCC is diagnosed in chronic liver disease (CLD) and cirrhosis background. The consumption of a Western-style high-fat diet is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), both of which are becoming more prevalent in parallel with the obesity epidemic. Excessive alcohol intake also contributes significantly to the CLD burden in the form of alcoholic liver disease (ALD). Inflammation is a key component in the development of all CLDs. Additionally, during the development of liver metastasis, pro-inflammatory signaling is crucial in eliminating invading cancer cells but ironically also helps foster a pro-metastatic environment that supports metastatic seeding and colonization. Here we review how Westernized high-fat diets and excessive alcohol intake can influence inflammation within the liver microenvironment, stimulating both primary and metastatic liver tumorigenesis.

scholarly journals Excessive Alcohol Intake Increases the Risk of Arterial Stiffening in Men with Normal Blood Pressure

2004 ◽  
Vol 27 (9) ◽  
pp. 669-673 ◽  
Author(s):  
Takashi KURIHARA ◽  
Hirofumi TOMIYAMA ◽  
Hideki HASHIMOTO ◽  
Yoshio YAMAMOTO ◽  
Eiji YANO ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Alcohol Intake ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Arterial Stiffening ◽  
Excessive Alcohol ◽  
Excessive Alcohol Intake

Early life temperamental anxiety is associated with excessive alcohol intake in adolescence: A rhesus monkey ( Macaca mulatta ) model

2019 ◽  
Vol 25 (6) ◽  
Author(s):  
Elizabeth K. Wood ◽  
Ryno Kruger ◽  
Elysha Cash ◽  
Stephen G. Lindell ◽  
Melanie L. Schwandt ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Macaca Mulatta ◽  
Early Life ◽  
Alcohol Intake ◽  
Excessive Alcohol ◽  
Excessive Alcohol Intake

Chlormethiazole Abuse

1979 ◽  
Vol 134 (6) ◽  
pp. 627-629 ◽  
Author(s):  
Elizabeth Gregg ◽  
Iftikhar Akhter
Keyword(s):  
Alcohol Intake ◽  
Drug Seeking ◽  
Excessive Alcohol ◽  
Symptoms And Signs ◽  
Excessive Alcohol Intake

SummaryThis report describes 17 cases of chlormethiazole abuse or dependence. These include one case with symptoms and signs of withdrawal and two other similar cases where undoubted dependence was combined with excessive alcohol intake. Seven other patients with alcoholism who indulged in drug-seeking behaviour involving chlormethiazole are also reported, together with a further seven abusers of various other drugs who were also discovered to be taking chlormethiazole.

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