scholarly journals Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019

2020 ◽  
Vol 71 (16) ◽  
pp. 2174-2179 ◽  
Author(s):  
Xiaomin Luo ◽  
Wei Zhou ◽  
Xiaojie Yan ◽  
Tangxi Guo ◽  
Benchao Wang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Neutrophil Count ◽  
Predictive Value ◽  
Prognostic Value ◽  
Operating Characteristic ◽  
Adverse Outcome ◽  
Elevated Serum ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Background An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). Methods Data for COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19. Results Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all P < .05). With a cutoff value of 41.4, CRP exhibited sensitivity of 90.5%, specificity of 77.6%, positive predictive value of 61.3%, and negative predictive value of 95.4%. CRP was also an independent discriminator of severe/critical illness on admission with an AUC (0.783) comparable to age (0.828) and neutrophil count (0.729) (both P > .05). Conclusions In patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome.

scholarly journals Prognostic value of C-reactive protein in patients with COVID-19

2020 ◽  
Author(s):  
Xiaomin Luo ◽  
Wei Zhou ◽  
Xiaojie Yan ◽  
Tangxi Guo ◽  
Benchao Wang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Disease Severity ◽  
Neutrophil Count ◽  
Predictive Value ◽  
Prognostic Value ◽  
Outcome Prediction ◽  
Adverse Outcome ◽  
C Reactive Protein ◽  
Reactive Protein

AbstractBackgroundElevated serum C-reactive protein (CRP) level was observed in most patients with COVID-19.MethodsData of COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from Jan 30 to Feb 20, 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19.ResultsOut of 298 patients enrolled, 84 died and 214 recovered. Most non-survivors tended to be males, old aged, or with chronic diseases. Compared to survivors, non-survivors showed significantly elevated white blood cell and neutrophil count, neutrophil to lymphocyte ratio (NLR), systemic immune-inflammation index (SII, defined by platelet count multiply by NLR), CRP, procalcitonin, and D-dimer, and decreased red blood cell, lymphocyte, and platelet count. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all p<0.05). With a cut-off value of 41.4, CRP exhibited sensitivity 90.5%, specificity 77.6%, positive predictive value 61.3%, and negative predictive value 95.4%. Subgroup analysis revealed that CRP remained robust accuracy in adverse outcome prediction in patients with different disease severity (AUC 0.832, z=10.23, p<0.001; AUC 0.989, z=44.04, p<0.001). CRP was also an independent discriminator of severe/critical illness on admission (AUC 0.783, z=10.69, p<0.001).ConclusionsIn patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome.

scholarly journals Serum peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in combination with C-reactive protein and white blood cell as novel predictors for infants with community-acquired pneumonia

2020 ◽  
Vol 18 ◽  
pp. 205873922094234
Author(s):  
Heng Xue ◽  
Hui Liu ◽  
Liangpu Xu ◽  
Qiaoling Liu ◽  
Bimin Zhuo ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Roc Curve ◽  
Predictive Value ◽  
Clinical Manifestations ◽  
Community Acquired Pneumonia ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Roc Curve Analysis ◽  
Reactive Protein

The aim of this study was to investigate the predictive value of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with C-reactive protein (CRP) and white blood cell (WBC) count for community-acquired pneumonia (CAP) in infants. A total of 84 hospitalized infants with CAP and 69 healthy infants were included in this study. The clinical manifestations and laboratory assay results of infants were recorded. Serum Pin1 level was estimated by enzyme-linked immunosorbent assay. The median serum Pin1 concentration in infants with CAP was significantly higher than that in controls (1.44 vs. 0.21 ng/mL, P < 0.0001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) of the combination Pin1, CRP and WBC (Pin1 + CRP + WBC, 0.943) was higher than Pin1, CRP, WBC alone or the combination of Pin1 and CRP ( P < 0.05). The sensitivity of Pin1 + CRP + WBC (94.0%) was higher than that of Pin1, CRP, WBC alone, or any two combined ( P < 0.05). Pin1 + CRP + WBC also had a high negative predictive value (91.4%). Moreover, serum Pin1 alone had a high specificity (97.0%) and excellent positive predictive value (96.6%) for infants with CAP, which were higher than WBC, Pin1 and WBC in combination, CRP and WBC in combination, and Pin1 + CRP + WBC ( P < 0.05). Therefore, serum Pin 1 was highly expressed in infants with CAP and can singly or in combination with CRP and WBC represent promising novel predictors for infants with CAP.

scholarly journals Neutrophil count to albumin ratio as a new predictor of mortality in patients with COVID-19 ınfection

2020 ◽  
Vol 66 (suppl 2) ◽  
pp. 77-81 ◽  
Author(s):  
Ceyhun Varim ◽  
Selcuk Yaylaci ◽  
Taner Demirci ◽  
Tezcan Kaya ◽  
Ahmet Nalbant ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Mortality Risk ◽  
Demographic Data ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Severe Group ◽  
Group 2 ◽  
Group 1

SUMMARY BACKGROUND Coronavirus Disease 2019 is an acute inflammatory respiratory disease. It causes many changes in hemogram parameters. Low albumin levels are associated with mortality risk in hospitalized patients. The aim of the present study is to reveal the place of neutrophil count to albumin ratio in predicting mortality in patients with COVID-19. METHODS 144 patients, 65 females and 79 males, were included in the study. Patients were divided into 2 groups. Group 1 was the non-severe group (n:85), and Group 2 was severe (n:59). Demographic data, neutrophil, lymphocyte and platelet counts, albumin and C-reactive protein (CRP) levels were recorded. Neutrophil count to albumin ratio (NAR) was calculated by dividing the absolute neutrophil counts by the albumin levels. The NAR and levels of the two groups were then compared. RESULTS There were no significant differences in gender and platelet count (201 vs. 211 K/mL) between the groups (p>0,05). Ages (62.0 ± 14.3 vs 68.6 ± 12.2 years), albumin (33.1 vs 29.9 gr/L), CRP (33 vs 113 mg/l), neutrophil count (4 vs 7.24 K/mL), WBC counts (6.70 vs 8.50 K/mL), NAR values (113.5 vs 267.2) and number of Death (5 vs 33) were found to be statistically higher (p <0.001) in Group 2 than in Group 1. The NAR value of 201.5 showed mortality in all patients with COVID-19 to have 71.1% sensitivity and 71.7% specificity (AUC:0.736, 95% CI: 0.641-0.832, p<0.001) CONCLUSION The present study showed that NAR levels can be a cheap and simple marker for predicting mortality in patients with COVID-19.

Predictive value of white blood cell count and C-reactive protein in children with appendicitis

2007 ◽  
Vol 42 (7) ◽  
pp. 1208-1214 ◽  
Author(s):  
Marcelo A. Beltrán ◽  
Jorge Almonacid ◽  
Alfonso Vicencio ◽  
Jorge Gutiérrez ◽  
Karina S. Cruces ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Predictive Value ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein

Phospholipase A2, C-reactive protein, and white blood cell count in the diagnosis of acute appendicitis

1994 ◽  
Vol 40 (9) ◽  
pp. 1757-1760 ◽  
Author(s):  
J M Grönroos ◽  
J J Forsström ◽  
K Irjala ◽  
T J Nevalainen
Keyword(s):  
Acute Appendicitis ◽  
Blood Cell ◽  
Phospholipase A2 ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Predictive Value ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein

Abstract We compared the predictive value of determining group II phospholipase A2 (PLA2) in serum for diagnosing acute appendicitis with the predictive values of white blood cell count (WBC) and measurement of C-reactive protein (CRP). In this prospective study, we included 186 patients who were undergoing appendectomy after clinical diagnoses of acute appendicitis. The performance of each test was measured by receiver-operating characteristic curves. WBC was the test of choice in diagnosing uncomplicated acute appendicitis. However, in contrast to CRP and PLA2, which increased in patients with protracted inflammation, there was not a concomitant increase in WBC. Therefore, especially CRP, but also PLA2, were better indicators of appendiceal perforation or abscess formation than was WBC. Increased WBC, CRP, and PLA2 values did not unequivocally corroborate the clinical suspicion of appendicitis, but if all three values were within normal limits, acute appendicitis could be excluded with a 100% predictive value. PLA2 values showed a highly significant correlation with CRP but not with WBC values, which supports the view that PLA2 represents an acute-phase reactant.

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