Valorization of Red Onion Peels for Quercetin Recovery Using Quercetin-Imprinted Polymer

2019 ◽  
Vol 58 (2) ◽  
pp. 163-170
Author(s):  
Şeyda Karaman Ersoy ◽  
Esma Tütem ◽  
Kevser Sözgen Başkan ◽  
Reşat Apak
Keyword(s):  
Solid Phase ◽  
Agricultural Waste ◽  
Nutritional Supplement ◽  
Bulk Polymerization ◽  
Molar Ratio ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Onion Peel ◽  
Hydrolysis Process ◽  
Valuable Product

Abstract Quercetin (QC) is one of the most prominent dietary antioxidants present in vegetables/fruits, specifically in onions that rank second in consumption following tomato. QC with proven health benefits is now largely utilized as a nutritional supplement. In this work that aims to isolate QC from red onion peels forming a huge agricultural waste, a QC-molecularly imprinted polymer (QC-MIP) in a molar ratio of 1:4:20 (QC:4-vinylpyridine:ethylene glycol dimethacrylate) was prepared thermally through bulk polymerization. Molecularly imprinted solid phase extraction (MISPE) procedures were applied for the selective pre-concentration and purification of QC from both red onion peel methanolic extract with 58% recovery and from the extract hydrolyzate with 86% recovery. The hydrolysis process increased both the QC amount as expected and the recovery yield due to changing matrix components. The results demonstrated that onion peel can easily and efficiently be converted to a valuable product, QC, using QC-MIP as SPE sorbent.

scholarly journals Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum

2018 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Meilia Suherman ◽  
Ike Susanti ◽  
Driyanti Rahayu ◽  
Rimadani Pratiwi ◽  
Aliya Nur Hasanah
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Therapeutic Index ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Precipitation Polymerization ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
As Doping ◽  
Recovery Percentage

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.

scholarly journals Synthesis and Evaluation of Molecularly Imprinted Polymer for the Determination of the Phthalate Esters in the Bottled Beverages by HPLC

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Ya-Feng Jin ◽  
Yi-Jun Zhang ◽  
Yu-Ping Zhang ◽  
Jun Chen ◽  
Xiao-Mao Zhou ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Phthalate Esters ◽  
Bulk Polymerization ◽  
Sample Volume ◽  
Scatchard Analysis ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Relative Standard ◽  
Ethylene Dimethacrylate

A molecularly imprinted polymer (MIP) was prepared in acetonitrile by bulk polymerization, using di-n-octylphthalate (DOP) as a template molecular,α-methacrylic acid (MAA) as a functional monomer, and ethylene dimethacrylate (EDMA) as a crosslinker. Characterization and evaluation of the prepared MIP were carried out by scanning electron microscope (SEM), infrared absorption spectroscopy (IR), and the Scatchard analysis, respectively. Through the optimization of washing solvent, eluting solvent amount, flow rate of loading solution, and loading sample volume, an analysis method was established for DOP related compounds with high selectivity and sensitivity by using the selective molecularly imprinted solid-phase extraction (MI-SPE) technique. Moreover, under the optimal conditions, the extraction effects were comparatively investigated by using MIP cartridge, NIP cartridge, and the commercial PLS cartridge used especially for phthalic acid esters (PAEs), respectively. The results showed that the recoveries of spiked PAEs are in the range of 90.4%–97.8% with the relative standard deviation (RSD) of 1.6%–3.8% on the resulted MIP cartridge, whilst lower recoveries were obtained ranging from 80.2% to 88.9% with an RSD of 1.4%–5.2% on the commercial PLS cartridge.

scholarly journals Molecularly imprinted polymers for solid phase extraction of orghanophosphorus pesticides

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohd Marsin Sanagi ◽  
Syairah Salleh ◽  
Wan Aini Wan Ibrahim ◽  
Ahmedy Abu Naim
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Organophosphorus Pesticides ◽  
Soxhlet Extraction ◽  
Molar Ratio ◽  
Template Molecule ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Influence Of Process Parameters ◽  
Molecularly Imprinted

Molecularly imprinted polymer-solid phase extraction (MIP-SPE) adsorbent was prepared for the analysis of selected organophosphorus pesticides(OPPs) in environmental sample. In this work, the influence of process parameters on the preparation of imprinted polymer is presented. In theprocedure of polymerization, molecularly imprinted bulk polymer was prepared using quinalphos and methacrylic acid (MAA) as template molecule and functional monomer, respectively. The influence of the following parameters on recognition properties was investigated namely, types of crosslinker (ethylene glycol dimethacrylate (EGDMA) or divinylbenzene (DVB)) and porogenic solvents (acetonitrile, dichloromethane, toluene, chloroform). Molar ratio of template:functional monomer:cross linker was fixed at 1:4:20. Soxhlet extraction method was conducted to remove the imprint molecule in order to create the recognition sites. A blank/non-imprinted polymer (NIP) was produced simultaneously using identical procedure except in the absence of template molecule.

Synthesis and application of a molecularly imprinted polymer in selective solid-phase extraction of efavirenz from water

2019 ◽  
Vol 79 (2) ◽  
pp. 356-365 ◽  
Author(s):  
Sinothando P. Mtolo ◽  
Precious N. Mahlambi ◽  
Lawrence M. Madikizela
Keyword(s):  
Surface Water ◽  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Bulk Polymerization ◽  
Antiretroviral Drugs ◽  
Array Detector ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Abstract Efavirenz is one of the antiretroviral drugs widely used to treat the human immunodeficiency virus. Antiretroviral drugs have been found to be present in surface water and wastewater. Due to complexity of environmental samples, solid-phase extraction (SPE) is used for isolation and pre-concentration of antiretroviral drugs prior to their chromatographic analysis. However, the commercially available SPE sorbents lack selectivity, which tends to prolong the analysis time. Therefore, in this study a molecularly imprinted polymer was synthesized for the specific recognition of efavirenz and then applied as the SPE sorbent for its extraction from wastewater and surface water samples. The imprinted and non-imprinted polymers were synthesized using a bulk polymerization technique where efavirenz was used as the template, 2-vinylpyridine as functional monomer, 1,1′-azobis-(cyclohexanecarbonitrile) as initiator, ethylene glycol dimethacrylate as cross-linker and toluene:acetonitrile (9:1, v/v) as the porogenic solvent mixture. The characterization was performed using Fourier transform infrared spectroscopy, scanning electron microscopy, Brunauer–Emmett–Teller, elemental analysis, and thermogravimetric analysis techniques. Results showed better selectivity of molecularly imprinted polymer to efavirenz than did non-imprinted polymer. The analysis was performed using high performance liquid chromatography equipped with a photo-diode array detector. The analytical method gave a detection limit of 0.41 μg/L and the analyte recovery of 81% in wastewater. The concentrations found in wastewater ranged from 2.79 to 120.7 μg/L, while in surface water they were between 0.975 and 2.88 μg/L. Therefore, the results of this study show a strong need for a detailed screening of efavirenz in major water utilities in the country.

Synthesis of nicotinamide-imprinted polymers and their binding performances in organic and aqueous media

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pattarawarapan Mookda ◽  
Komkham Singha ◽  
Kareuhanon Weeranuch ◽  
Tayapiwatana Chatchai
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Bulk Polymerization ◽  
Molar Ratio ◽  
Imprinted Polymer ◽  
Isolation And Identification ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractTo obtain molecularly imprinted polymers capable of selective rebinding with nicotinamide (NAM), NAM imprinted polymers were synthesized via bulk polymerization using various functional monomers and cross-linkers. The NAM recognition properties of these polymers were investigated in organic and aqueous solvents by equilibrium rebinding experiments. The results show that the imprinted polymer prepared using 1:4:4 molar ratio of NAM/MAA/TRIM in dichloromethane exhibited the greatest NAM binding capacity and selectivity. This polymer is potentially valuable for the analysis of NAM in complex matrices where selective isolation and identification are needed.

scholarly journals Examination of the Chemical Composition of Propolis IX. Solid Phase Extraction of Coumarins from Propolis by Using Molecularly Imprinted Polymer

2013 ◽  
Vol 12 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Katarína Hroboňová ◽  
Jozef Lehotay ◽  
Jozef Čižmárik
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Hplc Analysis ◽  
Chromatographic Method ◽  
Solid Phase ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Template Molecule ◽  
Synthetic Method ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Abstract The group selective molecularly imprinted polymers (MIPs) for coumarins, including umbelliferone, herniarin, 4-methylumbelliferone, scoparone were developed. Using umbelliferone as the template molecule, methacrylic acid as functional monomer, ethylene glycol dimethacrylate as linking agent, chloroform as porogen and bulk polymerization as synthetic method, the MIPs were synthesized and characterized with rebinding experiments. The characteristics of MIPs were evaluated by chromatographic method and frontal analysis, and demonstrating good selectivity and high binding capacity (269 μg of umbelliferone per 100 mg of polymer). The group selective MIP was used as sorbent for the SPE pretreatment of coumarins from propolis extracts prior to HPLC analysis. Analysis of the samples showed good recoveries (>70 %). The limits of quantitation (LOQs) for studied compounds were 0.3-10 ng.mL-1 (determined for fluorescence detection).

Sign in / Sign up

Export Citation Format

Share Document