Enantioseparation of Synthetic Cathinones Enantiomers with Tertiary Amine Structure in Urine and Plasma

2019 ◽  
Vol 57 (4) ◽  
pp. 361-368 ◽  
Author(s):  
Mohammed A Meetani ◽  
Rashed H Alremeithi ◽  
Muath K Mousa
Keyword(s):  
Tertiary Amine ◽  
Synthetic Cathinones ◽  
Amine Structure

The roles of tertiary amine structure, background organic matter and chloramine species on NDMA formation

2013 ◽  
Vol 47 (2) ◽  
pp. 945-953 ◽  
Author(s):  
Meric Selbes ◽  
Daekyun Kim ◽  
Nuray Ates ◽  
Tanju Karanfil
Keyword(s):  
Organic Matter ◽  
Tertiary Amine ◽  
Amine Structure

Preparation and properties of fluorinated oligomer with tertiary amine structure in the UV curable coatings

2016 ◽  
Vol 134 (2) ◽  
Author(s):  
Jianbing Wu ◽  
Ruofei Zhang ◽  
Guozhang Ma ◽  
Caiying Hou ◽  
Hui Zhang
Keyword(s):  
Tertiary Amine ◽  
Uv Curable ◽  
Fluorinated Oligomer ◽  
Amine Structure

Preparation and properties of polymerizable silica hybrid nanoparticles with tertiary amine structure

2011 ◽  
Vol 71 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Guozhang Ma ◽  
Wei Liu ◽  
Xuguang Liu ◽  
Jianbing Wu ◽  
Tao Yan ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Hybrid Nanoparticles ◽  
Amine Structure ◽  
Silica Hybrid

Alicyclic tertiary amine based hyperbranched polymers with excitation-independent emission: structure, fluorescence and applications

2019 ◽  
Vol 10 (17) ◽  
pp. 2170-2175 ◽  
Author(s):  
Miao Sun ◽  
Peng Song
Keyword(s):  
Tertiary Amine ◽  
Hyperbranched Polymers ◽  
Amine Structure

Influence of the tertiary amine structure and its position in the hyperbranched macromolecules on the fluorescence.

The Influence of Tertiary Amine Structure On Blow-To-Gel Selectivity

1993 ◽  
Vol 29 (5) ◽  
pp. 473-474 ◽  
Author(s):  
M.L. Listemann ◽  
A.L. Wressell ◽  
K.R. Lassila ◽  
H.C. Klotz ◽  
G.L. Johnson ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Amine Structure

scholarly journals Evaluation of Cytotoxic and Mutagenic Effects of the Synthetic Cathinones Mexedrone, α-PVP and α-PHP

2021 ◽  
Vol 22 (12) ◽  
pp. 6320
Author(s):  
Monia Lenzi ◽  
Veronica Cocchi ◽  
Sofia Gasperini ◽  
Raffaella Arfè ◽  
Matteo Marti ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Metabolic Activation ◽  
Fold Increase ◽  
Synthetic Cathinones ◽  
The Other ◽  
Oxygen Species ◽  
Genetic Damage ◽  
Mutagenic Potential ◽  
Tk6 Cells ◽  
Mutagenic Effects

Mexedrone, α-PVP and α-PHP are synthetic cathinones. They can be considered amphetamine-like substances with a stimulating effect. Actually, studies showing their impact on DNA are totally absent. Therefore, in order to fill this gap, aim of the present work was to evaluate their mutagenicity on TK6 cells. On the basis of cytotoxicity and cytostasis results, we selected the concentrations (35–100 µM) to be used in the further analysis. We used the micronucleus (MN) as indicator of genetic damage and analyzed the MNi frequency fold increase by flow cytometry. Mexedrone demonstrated its mutagenic potential contrary to the other two compounds; we then proceeded by repeating the analyzes in the presence of extrinsic metabolic activation in order to check if it was possible to totally exclude the mutagenic capacity for α-PVP and α-PHP. The results demonstrated instead the mutagenicity of their metabolites. We then evaluated reactive oxygen species (ROS) induction as a possible mechanism at the basis of the highlighted effects but the results did not show a statistically significant increase in ROS levels for any of the tested substances. Anyway, our outcomes emphasize the importance of mutagenicity evaluation for a complete assessment of the risk associated with synthetic cathinones exposure.

scholarly journals Design of ferrocenylseleno-dopamine derivatives to optimize the Fenton-like reaction efficiency and antitumor efficacy

RSC Advances ◽  
2021 ◽  
Vol 11 (41) ◽  
pp. 25477-25483
Author(s):  
Qianya Cheng ◽  
Tong Zhou ◽  
Qing Xia ◽  
Xiulian Lu ◽  
Heng Xu ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Antitumor Efficacy ◽  
Reaction Efficiency

The tertiary amine in F4b facilitates the Fenton-like reaction to generate toxic ˙OH which induces apoptosis through CDK-2 inactivation.

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