scholarly journals Development and Validation of a Stability-Indicating Liquid Chromatographic Method for Estimating Vilazodone Hydrochloride in Pharmaceutical Dosage Form Using Quality by Design

2016 ◽  
Author(s):  
Sagar Suman Panda ◽  
Venkata Varaha Bera Ravi Kumar ◽  
Sarwar Beg ◽  
Sunil Kumar Sahu ◽  
Swayamprabha Muni
Keyword(s):  
Dosage Form ◽  
Chromatographic Method ◽  
Quality By Design ◽  
Pharmaceutical Dosage Form ◽  
Stability Indicating ◽  
Liquid Chromatographic Method ◽  
Development And Validation ◽  
Liquid Chromatographic

scholarly journals Stability indicating liquid chromatographic method for the estimation of desvenlafaxine in pharmaceutical dosage form

2011 ◽  
Vol 17 (3) ◽  
pp. 341-348 ◽  
Author(s):  
Dimal Shah ◽  
Riddhi Nakrani ◽  
Sunil Baldania ◽  
Usmangani Chhalotiya ◽  
Kashyap Bhatt
Keyword(s):  
Dosage Form ◽  
Chromatographic Method ◽  
Potassium Dihydrogen Phosphate ◽  
Chemical Oxidation ◽  
Base Hydrolysis ◽  
Dihydrogen Phosphate ◽  
Pharmaceutical Dosage Form ◽  
Stability Indicating ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

A simple, sensitive, precise and stability indicating liquid chromatographic method has been developed for the estimation of desvenlafaxine succinate in pharmaceutical dosage form. A Hypersil C-18, 5 mm column with a mobile phase containing 0.05 M potassium dihydrogen phosphate: methanol (60:40 v/v) pH 7 was used. The flow rate was 1.0 mL/min and effluents were monitored at 226 nm. The retention time of desvenlafaxine was 7.4 min and the method was linear in the range of 0.1-20 ?g/mL. Desvenlafaxine stock solution was subjected to acid and alkali hydrolysis, chemical oxidation and dry heat degradation. The drug was found to be susceptible to base hydrolysis and developed method was found to give good separation between the pure drug and the degraded product. The method was successfully applied to the estimation of desvenlafaxine in tablet dosage forms.

Sign in / Sign up

Export Citation Format

Share Document